Induction of recombination activating gene expression in a human lymphoid progenitor cell line: requirement of two separate signals from stromal cells and cytokines

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures.

1990 • 574 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

1983 • 299 citations

Initiation of V(D)J recombination in a cell-free system

1995 • 286 citations

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.

1990 • 283 citations

The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

1996 • 281 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells.

1991 • 234 citations

Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-beta.

1989 • 229 citations

Isolation and Characterization of a Full-Length Expressible cDNA for Human Hypoxanthine Phosphoribosyltransferase

1983 • 222 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

Permissive role of interleukin 3 (IL‐3) in proliferation and differentiation of multipotential hemopoietic progenitors in culture

1985 • 214 citations

Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts

1988 • 177 citations

Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1)

1993 • 155 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.

1993 • 135 citations

Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues

1989 • 109 citations

In vitro hemopoiesis within a microenvironment created by MC3T3‐G2/PA6 preadipocytes

1984 • 100 citations

Development of a bone marrow culture for maintenance and growth of normal human B cell precursors.

1991 • 97 citations

Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.

1991 • 92 citations

Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors.

1995 • 90 citations

Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture

1994 • 86 citations

Interleukin 7-induced expression of specific T cell receptor gamma variable region genes in murine fetal liver cultures.

1993 • 69 citations

V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.

1990 • 64 citations

Function and Control of Recombination‐Activating Gene Activity^a

1992 • 58 citations

Analysis of the mechanisms of T cell-dependent polyclonal activation of human B cells. Induction of human B cell responses by fixed activated T cells.

1991 • 52 citations

Culture of human fetal B-cell precursors on bone marrow stroma maintains highly proliferative CD20dim cells

1993 • 51 citations

How B‐Precursor Cells are Driven to Cycle

1994 • 49 citations

Culture of human fetal B-cell precursors on bone marrow stroma maintains highly proliferative CD20dim cells

1993 • 44 citations

Cell cycle control of c-kit+IL-7R+ B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium.

1995 • 41 citations

Expression of the V(D)J recombinase gene RAG-1 is tightly regulated and involves both transcriptional and post-transcriptional controls

1992 • 24 citations

Expression of the CD2 molecule on human B lymphoid progenitors

1992 • 23 citations

Recombinase activating gene expression in thymic subpopulations. A transitional cell type has lost RAG-2 but not RAG-1.

1993 • 16 citations

Generation of Cells with Morphological and Antigenic Properties of Microglia from Cloned EBV-Transformed Lymphoid Progenitor Cells Derived from Human Fetal Liver

1993 • 15 citations

V(D)J recombinase activity in primary and secondary murine lymphoid organs: assessment by a PCR assay with extrachromosomal plasmids

1991 • 7 citations

Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture

1994 • 6 citations