Genetic and Functional Studies of Guanine Nucleotide-Binding Regulatory Proteins

Automatic Recording Apparatus for Use in Chromatography of Amino Acids

1958 • 9,612 citations

Advances in Cyclic Nucleotide Research.

1980 • 1,465 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase.

1982 • 351 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins.

1983 • 304 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.

1978 • 281 citations

Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase

1975 • 276 citations

Defect of Receptor–Cyclase Coupling Protein in Pseudohypoparathyroidism

1980 • 270 citations

Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.

1981 • 257 citations

Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism

1980 • 240 citations

Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.

1983 • 237 citations

Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.

1982 • 221 citations

Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.

1977 • 173 citations

Advances in Cyclic Nucleotide Research

1981 • 173 citations

Chemical Structure of a Modification of the Escherichia coli Ribonucleic Acid Polymerase α Polypeptides Induced by Bacteriophage T4 Infection

1974 • 164 citations

Cholera toxin activation of adenylate cyclase. Roles of nucleoside triphosphates and a macromolecular factor in the ADP ribosylation of the GTP-dependent regulatory component.

1980 • 148 citations

A guanine nucleotide-sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae.

1983 • 124 citations

Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity.

1981 • 97 citations

The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein.

1980 • 92 citations

Chapter 14 Cyclic-Nucleotide Metabolism in Vertebrate Photoreceptors: A Remarkable Analogy and an Unraveling Enigma

1981 • 87 citations

Structure and Activity of Diphtheria Toxin

1982 • 80 citations

Transducin: an amplifier protein in vision

1981 • 79 citations

Primary structure at the site in beef and wheat elongation factor 2 of ADP‐ribosylation by diphtheria toxin

1979 • 73 citations

Fibroblast Defect in Pseudohypoparathyroidism, Type I: Reduced Activity of Receptor-Cyclase Coupling Protein*

1981 • 67 citations

DEFICIENT ACTIVITY OF RECEPTOR-CYCLASE COUPLING PROTEIN IN PLATELETS OF PATIENTS WITH PSEUDOHYPOPARATHYROIDISM

1980 • 60 citations

Genetic analysis of hormone-sensitive adenylate cyclase.

1980 • 59 citations

Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism.

1983 • 55 citations

Deficient Activity of Receptor-Cyclase Coupling Protein in Transformed Lymphoblasts of Patients with Pseudohypoparathyroidism, Type I*

1982 • 48 citations

Effects of nucleoside triphosphates on choleragen-activated brain adenylate cyclase

1980 • 44 citations

Novel S49 lymphoma variants with aberrant cyclic AMP metabolism.

1981 • 40 citations

Characteristics of the Guanine Nucleotide-Binding Regulatory Component of Adenylate Cyclase

1982 • 33 citations

Deficiency of hormone receptor-adenylate cyclase coupling protein: basis for hormone resistance in pseudohypoparathyroidism

1982 • 32 citations

Characterization of an ATP-Mg2+-dependent guanine nucleotide-stimulated adenylate cyclase from Neurospora crassa

1983 • 32 citations

Three adenylate cyclase phenotypes in S49 lymphoma cells produced by mutations of one gene.

1982 • 29 citations

Reconstitution of adenylate cyclase in Neurospora from two components of the enzyme

1983 • 21 citations

Pseudohypoparathyroidism: mutation affecting adenylate cyclase.

1982 • 21 citations