Open-Channel Blockers at the Human α4β2 Neuronal Nicotinic Acetylcholine Receptor

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms

1995 • 549 citations

Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons

1985 • 527 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine

1997 • 344 citations

Liquid filament switch for ultra-fast exchanges of solutions at excised patches of synaptic membrane of crayfish muscle

1987 • 297 citations

Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells.

1979 • 295 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism.

1997 • 275 citations

The actions of tubocurarine at the frog neuromuscular junction.

1979 • 265 citations

Voltage jump analysis of procaine action at frog end‐plate

1977 • 230 citations

Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.

1996 • 172 citations

Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study.

1996 • 169 citations

Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes.

1990 • 157 citations

Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study

1996 • 154 citations

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders

1995 • 142 citations

The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels.

1990 • 130 citations

PARALYSIS OF AUTONOMIC GANGLIA BY METHONIUM SALTS

1951 • 121 citations

Synaptic transmission in the sympathetic ganglion of the frog

1963 • 111 citations

Therapeutic brain concentration of the NMDA receptor antagonist amantadine

1995 • 109 citations

Comparative Patch‐clamp Studies with Freshly Dissociated Rat Hippocampal and Striatal Neurons on the NMDA Receptor Antagonistic Effects of Amantadine and Memantine

1996 • 107 citations

The channel‐blocking action of methonium compounds on rat submandibular ganglion cells

1997 • 98 citations

The channel‐blocking action of methonium compounds on rat submandibular ganglion cells

1984 • 97 citations

MK‐801 inhibition of nicotinic acetylcholine receptor channels

1991 • 94 citations

Nicotinic receptor: an allosteric protein specialized for intercellular communication

1995 • 93 citations

Structural basis for explaining open-channel blockade of the NMDA receptor

1995 • 72 citations

A voltage‐clamp study of the effect of two lidocaine derivatives on the time course of end‐plate currents.

1976 • 69 citations

Amantadine: Neuromuscular Blockade by Suppression of Ionic Conductance of the Acetylcholine Receptor

1978 • 58 citations

Mechanism of action of amantadine on neuromuscular transmission.

1978 • 58 citations

Effect of MK-801 at the human α7 nicotinic acetylcholine receptor

1996 • 57 citations

Twenty-five years of amantadine therapy in Parkinson's disease.

1995 • 54 citations

Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

1992 • 48 citations

Datac: A multipurpose biological data analysis program based on a mathematical interpreter

1986 • 45 citations

Amantadine inhibits nicotinic acetylcholine receptor function in hippocampal neurons.

1997 • 42 citations

The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, non-competitive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes.

1995 • 33 citations

Minireview: Electrophysiology: A Method to Investigate the Functional Properties of Ligand-Gated Channels

1997 • 16 citations