Amantadine inhibits nicotinic acetylcholine receptor function in hippocampal neurons.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin

1985 • 1,037 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

1996 • 955 citations

Antiviral Activity of 1-Adamantanamine (Amantadine)

1964 • 805 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.

1993 • 543 citations

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

1995 • 300 citations

alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability

1995 • 264 citations

Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist.

1992 • 242 citations

Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine.

1996 • 223 citations

Nicotinic Modulation of [³H]Dopamine Release from Striatal Synaptosomes: Pharmacological Characterisation

1990 • 198 citations

Nicotinic Receptor Function in the Mammalian Central Nervous System^a

1995 • 155 citations

Amantadine in Parkinson's Disease

1972 • 133 citations

The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

1985 • 130 citations

Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

1993 • 122 citations

Therapeutic brain concentration of the NMDA receptor antagonist amantadine

1995 • 109 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization.

1994 • 109 citations

Direct Measurement of the Influenza A Virus M2 Protein Ion Channel Activity in Mammalian Cells

1994 • 101 citations

Neutron Diffraction Reveals the Site of Amantadine Blockade in the Influenza A M2 Ion Channel

1994 • 97 citations

The anti-parkinsonian drug amantadine inhibits the N-methyl-D-aspartic acid-evoked release of acetylcholine from rat neostriatum in a non-competitive way

1992 • 94 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. III. Agonist actions of the novel alkaloid epibatidine and analysis of type II current.

1995 • 82 citations

Inhibitory effects of the antiparkinsonian drugs memantine and amantadine on N-methyl-D-aspartate-evoked acetylcholine release in the rabbit caudate nucleus in vitro.

1992 • 74 citations

Nicotinic acetylcholine receptors in cultured neurons from the hippocampus and brain stem of the rat characterized by single channel recording

1987 • 68 citations

Brief-lifetime, fast-inactivating ion channels account for the α-bungarotoxin-sensitive nicotinic response in hippocampal neurons

1993 • 66 citations

Phase-shifting effect of 8-OH-DPAT, a 5-HT1A/5-HT7 receptor agonist, on locomotor activity in golden hamster in constant darkness

1996 • 61 citations

Mechanism of action of amantadine on neuromuscular transmission.

1978 • 58 citations

Amantadine: Neuromuscular Blockade by Suppression of Ionic Conductance of the Acetylcholine Receptor

1978 • 58 citations

A double-blind crossover comparison of antiparkinson drug therapy: amantadine versus anticholinergics in 90 normal volunteers, with an emphasis on differential effects on memory function.

1987 • 56 citations

Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.

1996 • 55 citations

Mapping the location of functional nicotinic and gamma-aminobutyric acidA receptors on hippocampal neurons.

1996 • 53 citations

Nicotinic responses in acutely dissociated rat hippocampal neurons and the selective blockade of fast-desensitizing nicotinic currents by lead.

1995 • 52 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. IV. Regulation by external Ca++ of alpha-bungarotoxin-sensitive receptor function and of rectification induced by internal Mg++.

1996 • 35 citations

Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors.

1996 • 30 citations

Structure-activity relationships of amantadine. I. Interaction of the N-alkyl analogues with the ionic channels of the nicotinic acetylcholine receptor and electrically excitable membrane.

1982 • 30 citations

Studies on the mechanism of action of the antiparkinsonian drugs memantine and amantadine: no evidence for direct dopaminomimetic or antimuscarinic properties.

1992 • 29 citations

Chapter 9 Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity

1996 • 27 citations

Neuronal nicotinic receptors: function, modulation and structure

1995 • 27 citations

Biochemical Characterization of a Novel Channel-Activating Site on Nicotinic Acetylcholine Receptors

1993 • 27 citations

Effect of add-on amantadine therapy for refractory absence epilepsy

1992 • 22 citations

Anticholinergic effects on memory: benztropine vs. amantadine.

1987 • 16 citations

Ligand-gated ion channels in acutely dissociated rat hippocampal neurons with long dendrites

1996 • 15 citations

Serum neuroleptic and anticholinergic activity in relationship to cognitive toxicity of antiparkinsonian agents in schizophrenic patients.

1987 • 15 citations

Functional Properties of the Nicotinic and Glutamatergic Receptors

1991 • 13 citations