Thiol oxidation by 2,2′-dithiodipyridine causes a reversible increase in cytoplasmic free Ca2+ concentration in pancreatic β-cells. Role for inositol 1,4,5-trisphosphate-sensitive Ca2+ stores

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Inositol Trisphosphate and Calcium Signaling

1995 • 1,036 citations

Alteration of intracellular Fura-2 fluorescence by viscosity: A simple correction

1990 • 319 citations

Redundant Mechanisms of Calcium-Induced Calcium Release Underlying Calcium Waves During Fertilization of Sea Urchin Eggs

1993 • 313 citations

Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants.

1990 • 198 citations

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells

1984 • 184 citations

Reactive disulfides trigger Ca2+ release from sarcoplasmic reticulum via an oxidation reaction

1989 • 158 citations

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic β-cells

1993 • 147 citations

Luminal Ca2+ promoting spontaneous Ca2+ release from inositol trisphosphate‐sensitive stores in rat hepatocytes.

1992 • 138 citations

Thimerosal causes calcium oscillations and sensitizes calcium‐induced calcium release in unfertilized hamster eggs

1991 • 129 citations

Glucagon-Like Peptide I Increases Cytoplasmic Calcium in Insulin-Secreting βTC3-Cells by Enhancement of Intracellular Calcium Mobilization

1995 • 128 citations

Specific covalent modification of thiols: Applications in the study of enzymes and other biomolecules

1979 • 118 citations

On the Relationship between Rate of ATP Synthesis and H⁺ Electrochemical Gradient in Rat‐Liver Mitochondria

1982 • 93 citations

Imaging of inositol 1,4,5-trisphosphate-induced Ca2+ fluxes in single permeabilized hepatocytes. Demonstration of both quantal and nonquantal patterns of Ca2+ release.

1993 • 87 citations

Nitric oxide induces intracellular Ca²⁺ mobilization and increases secretion of incorporated 5‐hydroxytryptamine in rat pancreatic β‐cells

1995 • 80 citations

Ca²⁺‐induced Ca²⁺ release in insulin‐secreting cells

1992 • 80 citations

Sulfhydryl oxidation induces rapid and reversible closure of the ATP‐regulated K⁺ channel in the pancreatic β‐cell

1993 • 76 citations

Ca2+ stores in insulin-secreting cells: lack of effect of cADP ribose

1994 • 70 citations

Effects of caffeine on cytoplasmic free Ca2+ concentration in pancreatic β-cells are mediated by interaction with ATP-sensitive K+ channels and L-type voltage-gated Ca2+ channels but not the ryanodine receptor

1995 • 61 citations

Mobilization of calcium by inositol trisphosphates from permeabilized rat parotid acinar cells. Evidence for translocation of calcium from uptake to release sites within the inositol 1,4,5-trisphosphate- and thapsigargin-sensitive calcium pool

1991 • 53 citations

Functional homogeneity of the non-mitochondrial Ca2+ pool in intact mouse lacrimal acinar cells.

1992 • 48 citations

Thimerosal potentiates Ca2+ release mediated by both the inositol 1,4,5-trisphosphate and the ryanodine receptors in sea urchin eggs. Implications for mechanistic studies on Ca2+ signaling

1994 • 46 citations

Oscillations in cytoplasmic free calcium concentration in human pancreatic islets from subjects with normal and impaired glucose tolerance

1994 • 40 citations

The pancreatic β-cell recognition of insulin secretagogues. VII. Binding and permeation of chloromercuribenzene-p-sulphonic acid in the plasma membrane of pancreatic β-cells

1973 • 31 citations

Mobilization of Ca2+ by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone in permeabilized insulin-secreting RINm5F cells: evidence for separate uptake and release compartments in inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1993 • 30 citations

A Possible Role of Intracellular and Membrane Thiols of Rat Pancreatic Islets in Calcium Uptake and Insulin Release*

1983 • 29 citations

High affinity C10-Oeq ester derivatives of ryanodine. Activator-selective agonists of the sarcoplasmic reticulum calcium release channel.

1994 • 29 citations

The Effect of Mersalyl on Inositol Trisphosphate Receptor Binding and Ion Channel Function

1995 • 28 citations

A role for Na/Ca exchange in the pancreatic B cell

1993 • 26 citations

Properties of immunoaffinity purified 106-kDa Ca2+ release channels from the skeletal sarcoplasmic reticulum

1992 • 22 citations

Effects of chemical modification of amino and sulfhydryl groups on KATP channel function and sulfonylurea binding in CRI-G1 insulin-secreting cells

1994 • 20 citations

Effect of thimerosal and other sulfhydryl reagents on calcium permeability in thymus lymphocytes

1995 • 18 citations

Sulphydryl requirement for insulin release from the perfused pancreas

1978 • 8 citations

Restoration of glycolysis and respiration in Ehrlich ascites tumor cells inhibited by 2,2'-dithiodipyridine

1968 • 3 citations