Review article: nonsteroidal anti-inflammatory drug-associated gastrointestinal complications—guidelines for prevention and treatment

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

1991 • 1,260 citations

Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

1995 • 1,071 citations

A Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs

1998 • 777 citations

Users' Guides to the Medical Literature

1994 • 776 citations

Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs

1998 • 742 citations

Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration.

1987 • 643 citations

PREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

1988 • 615 citations

Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs

1991 • 606 citations

Famotidine for the Prevention of Gastric and Duodenal Ulcers Caused by Nonsteroidal Antiinflammatory Drugs

1996 • 444 citations

Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine.

1988 • 388 citations

Nonsteroidal anti-inflammatory drug-associated gastropathy: Incidence and risk factor models

1991 • 364 citations

Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use.

1987 • 359 citations

Concurrent Use of Nonsteroidal Anti-inflammatory Drugs and Oral Anticoagulants Places Elderly Persons at High Risk for Hemorrhagic Peptic Ulcer Disease

1993 • 321 citations

Corticosteroids and peptic ulcer: meta‐analysis of adverse events during steroid therapy

1994 • 305 citations

Duodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs

1993 • 300 citations

Effect of ranitidine gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs

1989 • 244 citations

Prevention of Peptic Ulcer and Dyspeptic Symptoms with Omeprazole in Patients Receiving Continuous Non-Steroidal Anti-Inflammatory Drug Therapy: A Nordic Multicentre Study

1996 • 229 citations

Misoprostol Dosage in the Prevention of Nonsteroidal Anti-inflammatory Drug-Induced Gastric and Duodenal Ulcers: A Comparison of Three Regimens

1995 • 189 citations

Long-term nonsteroidal antiinflammatory drug use and Helicobacter pylori infection

1991 • 181 citations

Fatal upper gastrointestinal hemorrhage or perforation among users and nonusers of nonsteroidal anti-inflammatory drugs in Saskatchewan, Canada 1983

1988 • 175 citations

NSAID gastropathy: the second most deadly rheumatic disease? Epidemiology and risk appraisal.

1991 • 161 citations

NSAIDS, GASTROINTESTINAL INJURY, AND CYTOPROTECTION

1996 • 155 citations

Ranitidine in the treatment of non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers.

1991 • 149 citations

Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin--analysis of gastrointestinal bleeding during the UK-TIA trial.

1995 • 134 citations

From experiment to experience: Side effects of nonsteroidal anti-inflammatory drugs

1983 • 127 citations

Prevention of Nonsteroidal Anti-inflammatory Drug—Induced Gastrointestinal Mucosal Injury

1996 • 124 citations

The Effect of Chronic Aspirin Use on Duodenal and Gastric Ulcer Hospitalizations

1990 • 123 citations

Helicobacter pylori infection and development of gastric or duodenal ulcer in arthritic patients receiving chronic NSAID therapy. The Misoprostol Study Group.

1994 • 114 citations

Sucralfate treatment of nonsteroidal anti-inflammatory drug-induced gastrointestinal symptoms and mucosal damage

1987 • 113 citations

Nonsteroidal Anti-inflammatory Drugs and Hospitalization for Gastroesophageal Bleeding in the Elderly

1987 • 107 citations

Smoking, alcohol, and analgesics in dyspepsia and among dyspepsia subgroups: lack of an association in a community.

1994 • 105 citations

Misoprostol and ranitidine in the prevention of NSAID-induced ulcers: a prospective, double-blind, multicenter study.

1996 • 102 citations

Dyspepsia in NSAID Users

1989 • 101 citations

The cost-effectiveness of misoprostol in preventing serious gastrointestinal events associated with the use of nonsteroidal antiinflammatory drugs

1998 • 97 citations

Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double‐blind trial

1995 • 94 citations

Nonsteroidal antiinflammatory drug-associated gastric ulcers do not require Helicobacter pylori for their development.

1992 • 90 citations

Risk factors for serious nonsteroidal-induced gastrointestinal complications: regression analysis of the MUCOSA trial.

1996 • 82 citations

An endoscopic comparison of the effects of etodolac, indomethacin, ibuprofen, naproxen, and placebo on the gastrointestinal mucosa.

1987 • 80 citations

A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production

1995 • 74 citations

A Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Anti-inflammatory Drugs

1999 • 71 citations

A Randomized, Double-Blind, Crossover Comparative Endoscopy Study on the Gastroduodenal Tolerability of a Highly Specific Cyclooxygenase-2 Inhibitor, Flosulide, and Naproxen

1997 • 61 citations

Comparison of salsalate and aspirin on mucosal injury and gastroduodenal mucosal prostaglandins

1990 • 61 citations

Untitled

1998 • 50 citations

Omeprazole Compared with Misoprostol for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs

1999 • 50 citations

Treatment of endoscopy‐negative NSAID‐induced upper gastrointestinal symptoms with cimetidine: an international multicentre collaborative study

1988 • 45 citations

Is Misoprostol Cost-effective in the Prevention of Nonsteroidal Anti-inflammatory Drug—Induced Gastropathy in Patients With Chronic Arthritis?

1994 • 41 citations

Certain Nonsteroidal Antiinflammatory Drugs and Hospitalization for Upper Gastrointestinal Bleeding

1985 • 40 citations

Reduced risk of NSAID gastropathy (GI mucosal toxicity) with nonacetylated salicylate (salsalate): an endoscopic study.

1990 • 36 citations

Gastroduodenal mucosal damage with salsalate versus aspirin: Results of experimental models and endoscopic studies in humans

1990 • 32 citations

A double‐blind gastroscopic evaluation of the effects of etodolac and naproxen on the gastrointestinal mucosa of rheumatic patients

1991 • 27 citations

Helicobacter pylori seroprevalence in patients with rheumatoid arthritis: Effect of nonsteroidal anti-inflammatory drugs and gold compounds

1992 • 24 citations

Interobserver variation in assessment of gastroduodenal lesions associated with non-steroidal anti-inflammatory drugs.

1994 • 17 citations

Effectiveness of lansoprazole in the healing of NSAID-induced gastric ulcer in patients continuing to take NSAIDs

1998 • 14 citations

Public misunderstanding of nonsteroidal antiinflammatory drug (NSAID)-mediated gastrointestinal (GI) toxicity: A serious potential health threat

1998 • 13 citations

Can eradication of Helicobacter pylori prevent future development of peptic ulcers in patients receiving long-term continuous nonsteroidal anti-inflammatory drugs

1998 • 7 citations

Meta-analysis: Misoprostol reduces NSAID-induced gastrointestinal mucosal injury

1997 • 7 citations

Do non‐steroidal anti‐inflammatory drugs cause duodenal ulcer? Evaluation of basal acid output and ulcer complications

1996 • 7 citations

Failure of Helicobacter pylori eradication to influence site-specific relapse in high risk NSAID users: Results of a large six month double blind randomised controlled clinical trial

1998 • 7 citations

Effect of H. pylori status on healing of gastric ulcer in patients continuing to take NSAIDs and treated with lansoprazole or ranitidine

1998 • 6 citations

The prevalence of Helicobacter pylori (Hp) infection in long-term users of nonsteroidal antiinflammatory drugs (NSAIDS)

1998 • 4 citations

Effect of gastric mucosal protection in nonrheumatoid patients with short-term nonsteroidal anti-inflammatory drug therapy: a prospective randomized multicenter study.

1997 • 2 citations