Prevention of Nonsteroidal Anti-inflammatory Drug—Induced Gastrointestinal Mucosal Injury

Meta-analysis in clinical trials

1986 • 36,193 citations

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

The file drawer problem and tolerance for null results.

1979 • 7,706 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

An Assessment of Clinically Useful Measures of the Consequences of Treatment

1988 • 1,650 citations

Summing up: The Science of Reviewing Research

1987 • 1,530 citations

A method for assessing the quality of a randomized control trial

1981 • 1,370 citations

Meta-Analysis in Clinical Research

1987 • 1,269 citations

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

1991 • 1,260 citations

Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

1995 • 1,071 citations

Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials.

1990 • 960 citations

Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs

1992 • 956 citations

PREVENTION OF NSAID-INDUCED GASTRIC ULCER WITH MISOPROSTOL: MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

1988 • 615 citations

Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease

1991 • 402 citations

Toward an Epidemiology of Gastropathy Associated With Nonsteroidal Antiinflammatory Drug Use

1989 • 392 citations

Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine.

1988 • 388 citations

Duodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs

1993 • 300 citations

Effect of ranitidine gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs

1989 • 244 citations

The Relative Gastrointestinal Toxicity of the Nonsteroidal Anti-inflammatory Drugs

1987 • 220 citations

A quality assessment of randomized control trials of primary treatment of breast cancer.

1986 • 199 citations

Utilization of nonsteroidal antiinflammatory drugs

1985 • 190 citations

NSAID gastropathy: the second most deadly rheumatic disease? Epidemiology and risk appraisal.

1991 • 161 citations

Ranitidine in the treatment of non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers.

1991 • 149 citations

Double-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum

1988 • 139 citations

To what extent do congestive heart failure patients in sinus rhythm benefit from digoxin therapy? A systematic overview and meta-analysis

1990 • 121 citations

Cost-effectiveness of Misoprostol for Prophylaxis Against Nonsteroidal Anti-inflammatory Drug—Induced Gastrointestinal Tract Bleeding

1990 • 111 citations

Prevention of Gastroduodenal Injury Induced by Chromic Nonsteroidal Antiinflammatory Drug Therapy

1989 • 104 citations

A double-blind study of prophylactic effect of misoprostol on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects

1986 • 101 citations

Endoscopic comparison of cimetidine and sucralfate for prevention of naproxen-induced acute gastroduodenal injury

1990 • 97 citations

Prevalence of mucosal lesions in the stomach and duodenum due to chronic use of NSAID in patients with rheumatoid arthritis or osteoarthritis, and interim report on prevention by misoprostol of diclofenac associated lesions.

1991 • 89 citations

Economic Effects of Prophylactic Use of Misoprostol to Prevent Gastric Ulcer in Patients Taking Nonsteroidal Anti-inflammatory Drugs

1989 • 88 citations

A blinded endoscopic comparative study of misoprostol versus sucralfate and placebo in the prevention of aspirin-induced gastric and duodenal ulceration.

1988 • 83 citations

Economic evaluation of gastric ulcer prophylaxis in patients with arthritis receiving non-steroidal anti-inflammatory drugs

1990 • 83 citations

Efficacy of 12 Months' Misoprostol as Prophylaxis against IMSAID-induced Gastric Ulcers:A placebo-controlled trial

1994 • 77 citations

A Doubleblind Comparison of the Gastroduodenal Safety and Efficacy of Diclofenac and a Fixed Dose Combination of Diclofenac and Misoprostol in the Treatment of Rheumatoid Arthritis

1992 • 64 citations

Misoprostol Reduces Gastroduodenal Injury From One Week of Aspirin: An Endoscopic Study

1989 • 64 citations

A double-blind placebo-controlled comparison of the efficacy and safety of 50, 100, and 200 micrograms of misoprostol QID in the prevention of ibuprofen-induced gastric and duodenal mucosal lesions and symptoms.

1989 • 57 citations

THE PREVENTION AND HEALING OF ACUTE NON-STEROIDAL ANTI-INFLAMMATORY DRUG-ASSOCIATED GASTRODUODENAL MUCOSAL DAMAGE BY MISOPROSTOL

1993 • 55 citations

ARAMIS (the American Rheumatism Association Medical Information System). A prototypical national chronic-disease data bank.

1986 • 54 citations

Protection by misoprostol against naproxen-induced gastric mucosal damage

1987 • 54 citations

Overview of clinical safety with misoprostol

1985 • 51 citations

Overview of gastroduodenal mucosal protection

1988 • 51 citations

Nizatidine Prevents Peptic Ulceration in High-Risk Patients Taking Nonsteroidal Anti-inflammatory Drugs

1993 • 49 citations

Protective effect of enprostil against aspirin-induced gastroduodenal mucosal injury in man

1986 • 45 citations

Ranitidine Protects Against Gastroduodenal Mucosal Damage Associated With Chronic Aspirin Therapy

1987 • 44 citations

NSAID-Induced Gastroduodenal Damage

1993 • 44 citations

MISOPROSTOL—A LOGICAL THERAPEUTIC APPROACH TO GASTRODUODENAL MUCOSAL INJURY INDUCED BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS?

1991 • 41 citations

Ranitidine prevents duodenal ulcers associated with non‐steroidal anti‐inflammatory drug therapy

1991 • 29 citations

Economic evaluation of prophylactic treatment with Misoprostol in osteoarthritic patients treated with NSAIDs. The case of Belgium.

1990 • 29 citations

Misoprostol Treatment Exacerbates Abdominal Discomfort in Patients with Non-Ulcer Dyspepsia and Erosive Prepyloric Changes: A Double-Blind, Placebo-Controlled, Multicentre Study

1990 • 27 citations

Ranitidine: differential effects on gastric bleeding and mucosal damage induced by aspirin

1992 • 27 citations

A double-blind, placebo-controlled, 6-day evaluation of two doses of misoprostol in gastroduodenal mucosal protection against damage from aspirin and effect on bowel habits.

1991 • 26 citations

Meta-analysis of clinical trials based on censored end-points: simplified theory and implementation of the statistical algorithms on a microcomputer

1993 • 25 citations

Why are non‐steroidal anti‐inflammatory drugs important in peptic ulceration?

1987 • 24 citations

Cimetidine decreases indomethacin induced duodenal mucosal damage in patients with acute musculoskeletal disorders.

1988 • 24 citations

Epidemiology and NSAID induced gastropathy.

1991 • 23 citations

Ranitidine in the prevention of non-steroidal anti-inflammatory drug-associated gastric and duodenal ulceration in arthritic patients

1994 • 23 citations

[Cost-effectiveness of preventive treatment with misoprostol in non-steroidal anti-inflammatory agents related gastric ulcers].

1991 • 21 citations

Ranitidine bismuth citrate and aspirin‐induced gastric mucosal injury

1993 • 20 citations

Misoprostol prevents NSAID-induced gastroduodenal lesions in patients with osteoarthritis and rheumatoid arthritis.

1991 • 19 citations

RANITIDINE IN THE TREATMENT OF GASTRIC AND DUODENAL ULCERS ASSOCIATED WITH NON-STEROIDAL ANTI INFLAMMATORY DRUGS

1993 • 18 citations

Effect of longterm misoprostol coadministration with non-steroidal anti-inflammatory drugs: a histological study.

1995 • 16 citations

Indomethacin-Induced Gastroduodenal Damage Is Not Affected by Cotreatment with Ranitidine

1989 • 15 citations

Epidemiology of NSAID-induced gastropathy

1991 • 13 citations

Pathophysiology of NSAID‐induced gastroduodenal damage: epidemiology and mechanisms of action of therapeutic agents

1991 • 8 citations

Book ReviewThe History of Scurvy and Vitamin C

1987 • 3 citations

NSAIDs: New Approaches to Limiting Gastropathy

1989 • 3 citations

Controversies, dilemmas, and dialogues. What do you recommend for prophylaxis in an elderly woman with arthritis requiring NSAIDs for control?

1991 • 3 citations

Deleted Work

1955 • 0 citations