Biopharmaceutical Development in India: Recommendations on Collaboration and Innovation to Enable Affordable Healthcare

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

How many drug targets are there?

2006 • 3,319 citations

Lessons from 60 years of pharmaceutical innovation

2009 • 1,168 citations

Progressive Multifocal Leukoencephalopathy Complicating Treatment with Natalizumab and Interferon Beta-1a for Multiple Sclerosis

2005 • 1,060 citations

Universities–industry collaboration: A systematic review

2015 • 745 citations

Brokerage, Boundary Spanning, and Leadership in Open Innovation Communities

2007 • 715 citations

The cost of biopharmaceutical R&D: is biotech different?

2007 • 518 citations

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

2012 • 499 citations

Science Business: The Promise, the Reality and the Future of Biotech

2007 • 409 citations

Collaboration and Team Science: From Theory to Practice

2012 • 354 citations

Science Business: The Promise, the Reality and the Future of Biotech

1969 • 351 citations

The importance of new companies for drug discovery: origins of a decade of new drugs

2010 • 326 citations

Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy

2012 • 299 citations

Trends in Upstream and Downstream Process Development for Antibody Manufacturing

2014 • 296 citations

The translation of non-canonical open reading frames controls mucosal immunity

2018 • 199 citations

A semisynthetic organism engineered for the stable expansion of the genetic alphabet

2017 • 187 citations

Leveraging Knowledge Across Geographic Boundaries

2007 • 181 citations

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool

2014 • 178 citations

The economics of biosimilars.

2013 • 169 citations

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database

2017 • 141 citations

Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov

2018 • 136 citations

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

1995 • 112 citations

The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape

2017 • 99 citations

Therapeutic Monoclonal Antibodies

2009 • 89 citations

Business models and investment trends in the biotechnology industry in Europe

2002 • 69 citations

Adverse reactions to biologic agents: Focus on autoimmune disease therapies

2005 • 61 citations

Management of hiccups in palliative care patients

2017 • 53 citations

Trends in Modern Drug Discovery

2015 • 48 citations

High throughput automated microbial bioreactor system used for clone selection and rapid scale‐down process optimization

2017 • 44 citations

The Impact of the Entry of Biosimilars: Evidence from Europe

2018 • 36 citations

Rituximab

2014 • 34 citations

A Systematic Review of U.S. Biosimilar Approvals: What Evidence Does the FDA Require and How Are Manufacturers Responding?

2017 • 33 citations

The continuing evolution of the drug discovery process in the pharmaceutical industry

2001 • 31 citations

Suicidal thoughts end Amgen's blockbuster aspirations for psoriasis drug

2015 • 30 citations

Applicability of predictive toxicology methods for monoclonal antibody therapeutics: status Quo and scope

2016 • 26 citations

Factors influencing the economics of biosimilars in the US

2017 • 21 citations

Attrition in the Pharmaceutical Industry: Reasons, Implications, and Pathways Forward

2015 • 18 citations

Attrition in the Pharmaceutical Industry

2015 • 10 citations

The long and winding road to antibody therapeutics

2010 • 8 citations

Science lessons: What biotech taught me about management

2008 • 6 citations

Erratum: The importance of new companies for drug discovery: origins of a decade of new drugs

2010 • 2 citations

Evolution of mammary gland function: a study using monotreme models

2014 • 2 citations