Therapeutic Monoclonal Antibodies

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

1984 • 1,002 citations

Assembly of a Functional Immunoglobulin F _v Fragment in Escherichia coli

1988 • 973 citations

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

2008 • 893 citations

Crystal Structure of a Neutralizing Human IgG Against HIV-1: A Template for Vaccine Design

2001 • 887 citations

Antibody Pharmacokinetics and Pharmacodynamics

2004 • 872 citations

Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda

1989 • 810 citations

Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition

2003 • 769 citations

Structure of a V3-Containing HIV-1 gp120 Core

2005 • 732 citations

Standard conformations for the canonical structures of immunoglobulins 1 1Edited by I. A. Wilson

1997 • 687 citations

The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of α1→2 Mannose Residues on the Outer Face of gp120

2002 • 664 citations

Escherichia coli Secretion of an Active Chimeric Antibody Fragment

1988 • 575 citations

Antibody-antigen interactions: new structures and new conformational changes

1994 • 512 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41

2005 • 438 citations

Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12

2005 • 290 citations

Structural basis of tyrosine sulfation and V_H-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

2004 • 262 citations

Conformational isomerism and the diversity of antibodies.

1994 • 257 citations

The immunoglobulin fold family: sequence analysis and 3D structure comparisons

1999 • 252 citations

Analysis of the Antigen Combining Site: Correlations Between Length and Sequence Composition of the Hypervariable Loops and the Nature of the Antigen

2002 • 243 citations

Flexibility of human IgG subclasses.

1997 • 242 citations

The three-dimensional structure of an intact monoclonal antibody for canine lymphoma

1992 • 214 citations

Tyrosine Sulfation of Human Antibodies Contributes to Recognition of the CCR5 Binding Region of HIV-1 gp120

2003 • 199 citations

Covalent Display of Oligosaccharide Arrays in Microtiter Plates

2004 • 170 citations

Molecular basis of crossreactivity and the limits of antibody–antigen complementarity

1993 • 162 citations

Three-dimensional Structure of an Anti-steroid Fab′ and Progesterone-Fab′ Complex

1993 • 148 citations

Structural Basis of Enhanced Binding of Extended and Helically Constrained Peptide Epitopes of the Broadly Neutralizing HIV-1 Antibody 4E10

2006 • 128 citations

Antigen-induced conformational changes in antibodies: A problem for structural prediction and design

1994 • 72 citations

Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope^,

2004 • 48 citations

Structural Aspects of Antibodies and Antibody‐Antigen Complexes

2007 • 31 citations

ANTIBODY CDR H3 MODELING RULES: EXTENSION FOR THE CASE OF ABSENCE OF ARG H94 AND ASP H101

2006 • 13 citations