Simplified procedures for applying the polymerase chain reaction to routinely fixed paraffin wax sections.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

DNA sequence and expression of the B95-8 Epstein—Barr virus genome

1984 • 2,039 citations

The Polymerase Chain Reaction

1990 • 1,198 citations

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

1985 • 821 citations

An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences

1987 • 811 citations

Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction.

1988 • 748 citations

Detection of Cytomegalovirus in Urine from Newborns by Using Polymerase Chain Reaction DNA Amplification

1988 • 490 citations

Detection of Minimal Residual Cells Carrying the t(14;18) by DNA Sequence Amplification

1987 • 426 citations

Modification of enzymatic-ally amplified DNA for the detection of point mutations

1989 • 330 citations

Tissue extraction of DNA and RNA and analysis by the polymerase chain reaction.

1990 • 289 citations

Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.

1989 • 275 citations

Analysis of DNA extracted from formalin-fixed, paraffin-embedded tissues by enzymatic amplification and hybridization with sequence-specific oligonucleotides

1987 • 260 citations

The Design and Optimization of the PCR

1989 • 259 citations

DETECTION OF HTV1 DNA IN INFANTS AND CHILDREN BY MEANS OF THE POLYMERASE CHAIN REACTION

1988 • 246 citations

Southern blot analysis of DNA extracted from formalin-fixed pathology specimens.

1986 • 244 citations

Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimens.

1990 • 196 citations

Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology.

1988 • 190 citations

Analysis of DNA in fresh and fixed tissue by the polymerase chain reaction.

1990 • 178 citations

POLYMERASE CHAIN REACTION FOR DETECTION OF RESIDUAL LEUKAEMIA

1989 • 152 citations

A potent inhibitor ofTaqpolymerase copurifies with human genomic DNA

1988 • 147 citations

Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction.

1988 • 92 citations

In vitro amplification of hepatitis B virus sequences from liver tumour DNA and from paraffin wax embedded tissues using the polymerase chain reaction.

1989 • 69 citations

Southern blot analysis of DNA extracted from formol–saline fixed and paraffin wax embedded tissue

1988 • 50 citations

Demonstration of multiple HPV types in normal cervix and in cervical squamous cell carcinoma using the polymerase chain reaction on paraffin wax embedded material.

1990 • 49 citations

What Price Success? The Continuing Saga of the Toxic: Therapeutic Ratio in the Use of Aminoglycoside Antibiotics

1988 • 43 citations