Loss of Function of the Homeobox Gene Hoxa-9 Perturbs Early T-Cell Development and Induces Apoptosis in Primitive Thymocytes

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Hox genes in vertebrate development

1994 • 2,057 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6

1992 • 537 citations

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

1994 • 529 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP96 and class I homeoprotein HOXA9

1996 • 449 citations

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

1993 • 352 citations

Overexpression of HOXA10 in Murine Hematopoietic Cells Perturbs both Myeloid and Lymphoid Differentiation and Leads to Acute Myeloid Leukemia

1997 • 336 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Mice Bearing a Targeted Interruption of the Homeobox Gene HOXA9 Have Defects in Myeloid, Erythroid, and Lymphoid Hematopoiesis

1997 • 314 citations

Homeobox genes: Their function in Drosophila segmentation and pattern formation

1994 • 288 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain

1996 • 268 citations

The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

1996 • 239 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4.

1992 • 215 citations

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

1993 • 196 citations

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

1997 • 195 citations

Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins

1996 • 194 citations

Overexpression of HOXB3 in Hematopoietic Cells Causes Defective Lymphoid Development and Progressive Myeloproliferation

1997 • 187 citations

Cadherin-6 Expression Transiently Delineates Specific Rhombomeres, Other Neural Tube Subdivisions, and Neural Crest Subpopulations in Mouse Embryos

1997 • 185 citations

Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.

1988 • 172 citations

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.

1993 • 140 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation

1994 • 128 citations

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

1993 • 119 citations

A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo

1993 • 108 citations

IL-7 maintains the T cell precursor potential of CD3-CD4-CD8- thymocytes.

1991 • 100 citations

Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1.

1994 • 70 citations

Cell surface topography of thymic microenvironments.

1988 • 69 citations

Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells.

1994 • 63 citations

Involvement of E-Cadherin in Thymus Organogenesisand Thymocyte Maturation

1997 • 59 citations

Coordinate Expression and Proliferative Role of HOXB Genes in Activated Adult T Lymphocytes

1994 • 58 citations

Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes.

1994 • 40 citations

Generation of T-cell function in organ culture of foetal mouse thymus. II. Mixed lymphocyte culture reactivity.

1977 • 38 citations

Characterization of Cadherins Expressed by Murine Thymocytes

1996 • 33 citations