Pain Perception and Response: Central Nervous System Mechanisms

Pain Mechanisms: A New Theory

1965 • 10,272 citations

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION

1937 • 3,950 citations

Deciding Advantageously Before Knowing the Advantageous Strategy

1997 • 3,454 citations

Contributions of anterior cingulate cortex to behaviour

1995 • 3,315 citations

The somatic marker hypothesis and the possible functions of the prefrontal cortex

1996 • 2,603 citations

Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex

1997 • 2,540 citations

Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala

1994 • 2,309 citations

The prefrontal cortex

1997 • 2,139 citations

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex

1997 • 1,868 citations

AN ANATOMICAL STUDY OF CONVERGING SENSORY PATHWAYS WITHIN THE CEREBRAL CORTEX OF THE MONKEY

1970 • 1,701 citations

Motor Areas of the Medial Wall: A Review of Their Location and Functional Activation

1996 • 1,694 citations

Conscious and unconscious emotional learning in the human amygdala

1998 • 1,673 citations

Brain stem activation in spontaneous human migraine attacks

1995 • 1,366 citations

Functional Heterogeneity in Cingulate Cortex: The Anterior Executive and Posterior Evaluative Regions

1992 • 1,312 citations

Localization of a human system for sustained attention by positron emission tomography

1991 • 1,294 citations

The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction

1993 • 1,259 citations

Amygdalo‐cortical projections in the monkey (Macaca fascicularis)

1984 • 1,159 citations

Dissociating Pain from Its Anticipation in the Human Brain

1999 • 1,142 citations

Cortico-cortical connections in the rhesus monkey

1969 • 1,086 citations

The role of the anterior prefrontal cortex in human cognition

1999 • 1,020 citations

5-HT and mechanisms of defence

1991 • 1,017 citations

Multiple Representations of Pain in Human Cerebral Cortex

1991 • 971 citations

An Area Specialized for Spatial Working Memory in Human Frontal Cortex

1998 • 957 citations

Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey

1989 • 937 citations

Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior

1988 • 906 citations

Amygdala activity at encoding correlated with long-term, free recall of emotional information.

1996 • 906 citations

Cingulate cortex of the rhesus monkey: II. Cortical afferents

1987 • 859 citations

Behavioral changes associated with ablation of the amygdaloid complex in monkeys.

1956 • 818 citations

A perceptual-defensive-recuperative model of fear and pain

1980 • 811 citations

Distributed processing of pain and vibration by the human brain

1994 • 807 citations

Emotional memory systems in the brain

1993 • 805 citations

Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory corticocortical connections

1989 • 802 citations

Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey

1984 • 778 citations

Reshaping the Village Test for investigating service brand attachment

2014 • 771 citations

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1998 • 757 citations

Human cingulate cortex: Surface features, flat maps, and cytoarchitecture

1995 • 735 citations

An autoradiographic study of the projections of the central nucleus of the monkey amygdala

1981 • 694 citations

Dissociation of human mid-dorsolateral from posterior dorsolateral frontal cortex in memory processing.

1993 • 669 citations

The primate mediodorsal (MD) nucleus and its projection to the frontal lobe

1985 • 652 citations

Pain processing during three levels of noxious stimulation produces differential patterns of central activity

1997 • 632 citations

Central representation of chronic ongoing neuropathic pain studied by positron emission tomography

1995 • 630 citations

Cingulate cortex of the rhesus monkey: I. Cytoarchitecture and thalamic afferents

1987 • 601 citations

THE INSULA

1955 • 600 citations

Multiple Output Channels in the Basal Ganglia

1993 • 596 citations

The role of the amygdala in conditioned fear.

1992 • 591 citations

Selective representation of relevant information by neurons in the primate prefrontal cortex

1998 • 590 citations

Primary afferent tachykinins are required to experience moderate to intense pain

1998 • 587 citations

Functional imaging of an illusion of pain

1996 • 581 citations

Pain “Relief” by Frontal Cingulumotomy

1962 • 573 citations

Efferent connections of the cingulate gyrus in the rhesus monkey

1981 • 570 citations

Regional cerebral activity in normal and pathological perception of visceral pain

1997 • 567 citations

Carpenter's Human Neuroanatomy

1996 • 566 citations

Insula of the old world monkey. II: Afferent cortical input and comments on the claustrum

1982 • 547 citations

Cortical and subcortical localization of response to pain in man using positron emission tomography

1991 • 545 citations

Cortical connections of the somatosensory fields of the lateral sulcus of macaques: Evidence for a corticolimbic pathway for touch

1986 • 531 citations

Impaired auditory recognition of fear and anger following bilateral amygdala lesions

1997 • 523 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Mediodorsal nucleus: Areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys

1988 • 516 citations

THE DUALITY OF THE CINGULATE GYRUS IN MONKEY

1980 • 504 citations

Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli

1994 • 500 citations

Interconnections between the prefrontal cortex and the premotor areas in the frontal lobe

1994 • 497 citations

RETROSPLENIAL AMNESIA

1987 • 471 citations

Functional MRI Study of Thalamic and Cortical Activations Evoked by Cutaneous Heat, Cold, and Tactile Stimuli

1998 • 467 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

A new parcellation of the human thalamus on the basis of histochemical staining

1989 • 449 citations

Functional MRI of Pain- and Attention-Related Activations in the Human Cingulate Cortex

1997 • 437 citations

Diencephalic mechanisms of pain sensation

1985 • 412 citations

Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET

1998 • 393 citations

Thalamic and Cortical Afferents Differentiate Anterior from Posterior Cingulate Cortex in the Monkey

1979 • 390 citations

The Midbrain Periaqueductal Gray as a Coordinator of Action in Response to Fear and Anxiety

1991 • 387 citations

Pain Processing in Four Regions of Human Cingulate Cortex Localized with Co‐registered PET and MR Imaging

1996 • 380 citations

Nociceptive neurons in area 24 of rabbit cingulate cortex

1992 • 364 citations

What do the basal ganglia do?

1998 • 362 citations

THE FUNCTIONAL SIGNIFICANCE OF THE ROSTRAL CINGULAR CORTEX AS REVEALED BY ITS RESPONSES TO ELECTRICAL EXCITATION

1945 • 349 citations

Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography.

1994 • 322 citations

TERMINATION OF THE CENTRAL PAIN PATHWAY IN MAN: THE CONSCIOUS APPRECIATION OF PAIN

1957 • 315 citations

Central post-stroke pain — neurological symptoms and pain characteristics

1989 • 308 citations

Role of the amygdala and periaqueductal gray in anxiety and panic

1993 • 303 citations

Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain

1989 • 294 citations

Cingulate input to the primary and supplementary motor cortices in the rhesus monkey: Evidence for somatotopy in areas 24c and 23c

1992 • 284 citations

Experimental cranial pain elicited by capsaicin: a PET study

1998 • 278 citations

Connections of the Monkey Cingulate Cortex

1993 • 272 citations

Identification of human brain loci processing esophageal sensation using positron emission tomography

1997 • 262 citations

THE CINGULAR GYRUS: AREA 24

1948 • 260 citations

Temporal and Intensity Coding of Pain in Human Cortex

1998 • 259 citations

Peptide immunoreactive neurons in the amygdala and the bed nucleus of the stria terminalis project to the midbrain central gray in the rat

1992 • 259 citations

Central nervous pathways mediating angina pectoris

1994 • 257 citations

Thalamic and Brainstem Contributions to Large-Scale Plasticity of Primate Somatosensory Cortex

1998 • 257 citations

Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: a positron emission tomography study

1996 • 242 citations

An anatomical reinvestigation of the termination of the spinothalamic tract in the monkey

1979 • 237 citations

Norepinephrine Release in the Amygdala in Response to Footshock Stimulation

1996 • 231 citations

Sensory abnormalities in consecutive, unselected patients with central post-stroke pain

1995 • 228 citations

THE LIMBIC SYSTEM ("VISCERAL BRAIN") AND EMOTIONAL BEHAVIOR

1955 • 224 citations

Efferent cortico-cortical projections of the prefrontal cortex in the rhesus monkey

1971 • 215 citations

Nociceptive responses of neurons in medial thalamus and their relationship to spinothalamic pathways

1978 • 208 citations

Spontaneous neuronal hyperactivity in the medial and intralaminar thalamic nuclei of patients with deafferentation pain

1991 • 206 citations

Allodynia after lateral-medullary (Wallenberg) infarct. A PET study

1998 • 196 citations

Unit analysis of nociceptive mechanisms in the thalamus of the awake squirrel monkey.

1966 • 195 citations

Neuromodulatory systems and memory storage: Role of the amygdala

1993 • 192 citations

Sensory and affective aspects of pain perception: is medial thalamus restricted to emotional issues?

1989 • 189 citations

THE CONVERGENCE AND INTERACTION OF VISUAL, AUDITORY, AND TACTILE RESPONSES IN HUMAN NONSPECIFIC CORTEX

1964 • 189 citations

Cerebral responses to a continual tonic pain stimulus measured using positron emission tomography

1998 • 183 citations

A modality-specific somatosensory area within the insula of the rhesus monkey

1993 • 180 citations

Right-lateralised central processing for pain of nitroglycer-induced cluster headache

1996 • 178 citations

fMRI of human somatosensory and cingulate cortex during painful electrical nerve stimulation

1995 • 169 citations

In vivo distribution of opioid receptors in man in relation to the cortical projections of the medial and lateral pain systems measured with positron emission tomography

1991 • 165 citations

THE EFFECTS OF LESIONS IN THE CINGULAR GYRUS AND ADJACENT AREAS IN MONKEYS

1950 • 162 citations

Physiological Evidence Concerning Importance of the Amygdaloid Nuclear Region in the Integration of Circulatory Function and Emotion in Man

1954 • 162 citations

Differential distribution of corticospinal projections from individual cytoarchitectonic fields in the monkey

1977 • 156 citations

Anterior Cingulate Cortex in Rodents: Connections, Visceral Control Functions, and Implications for Emotion

1993 • 155 citations

Cingulate Motor Areas

1993 • 152 citations

Chapter 27 Pharmacologic evidence for the modulation of nociception by noradrenergic neurons

1988 • 149 citations

Corticomotoneuronal connections in the rat: Evidence from double‐labeling of motoneurons and corticospinal axon arborizations

1991 • 144 citations

Neurons in the area of human thalamic nucleus ventralis caudalis respond to painful heat stimuli

1993 • 142 citations

Motor areas of the cerebral cortex

1988 • 134 citations

Structural Organization of Cingulate Cortex: Areas, Neurons, and Somatodendritic Transmitter Receptors

1993 • 133 citations

Endogenous Opioid Peptides Acting at μ-Opioid Receptors in the Dorsal Horn Contribute to Midbrain Modulation of Spinal Nociceptive Neurons

1998 • 129 citations

Thalamic stimulation-evoked sensations in chronic pain patients and in nonpain (movement disorder) patients

1996 • 125 citations

Motor Control Function of the Prefrontal Cortex

2007 • 116 citations

Psychosurgery in the Treatment of Mental Disorders and Intractable Pain

1952 • 114 citations

Stimulation of the Central and Peripheral Nervous System for the Control of Pain

1997 • 113 citations

Direct spinal pathways to the limbic system for nociceptive information

1994 • 112 citations

Temporal processes of formalin pain: differential role of the cingulum bundle, fornix pathway and medial bulboreticular formation

1992 • 109 citations

A primitive gigantopyramidal field buried in the depth of the cingulate sulcus of the human brain

1976 • 105 citations

PREFRONTAL LEUCOTOMY: A NEURO-ANATOMICAL REPORT

1947 • 103 citations

Indirect nucleus accumbens input to the prefrontal cortex via the substantia nigra pars reticulata: A combined anatomical and electrophysiological study in the rat

1994 • 102 citations

STIMULATION STUDIES OF INSULAR CORTEX OF MACACA MULATTA

1953 • 101 citations

Cortical projections to the periaqueductal gray in the monkey: A retrograde and orthograde horseradish peroxidase study

1981 • 94 citations

Stereotactic Thalamotomy

1963 • 94 citations

Light and electron microscopic evidence for a direct corticospinal projection to superficial laminae of the dorsal horn in cats and monkeys

1984 • 94 citations

Limbic Thalamus: Structure, Intrinsic Organization, and Connections

1993 • 91 citations

Psychosurgery in the Treatment of Mental Disorders and Intractable Pain.

1951 • 89 citations

N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. II. Comparison across three swim-stress paradigms in selectively bred mice

1992 • 89 citations

Bilateral MRI-Guided Stereotactic Cingulotomy for Intr actable Pain

1992 • 85 citations

Mechanisms of chronic pain

1996 • 85 citations

Evidence for an amygdaloid projection to premotor cortex but not to motor cortex in the monkey

1983 • 84 citations

A STUDY OF EFFERENT CONNEXIONS OF THE FRONTAL LOBE IN THE HUMAN BRAIN AFTER LEUCOTOMY

1949 • 82 citations

Somatosensory cortex: A comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging

1998 • 81 citations

Nociceptive pathways: anatomy and physiology of nociceptive ascending pathways

1985 • 78 citations

A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli

1994 • 74 citations

Recordings of Abnormal Activity in Patients with Deafferentation and Central Pain

1989 • 67 citations

Cortical representation of pain

1992 • 67 citations

Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice

1998 • 62 citations

Event-related fMRI of pain

1998 • 60 citations

Thalamic Stimulation and Recording in Patients with Deafferentation and Central Pain

1989 • 59 citations

Distribution of tachykinin- and enkephalin-immunoreactive fibers in the human thalamus

1989 • 57 citations

Neurons in the Human Thalamic Somatosensory Nucleus (Ventralis Caudalis) Respond to Innocuous Cool and Mechanical Stimuli

1998 • 54 citations

Limbic thalamic, cingulate cortical and hippocampal neuronal correlates of discriminative approach learning in rabbits

1996 • 52 citations

Functional imaging of pain: new insights regarding the role of the cerebral cortex in human pain perception

1995 • 52 citations

Evidence for additional neurotensin receptor subtypes: neurotensin analogs that distinguish between neurotensin-mediated hypothermia and antinociception

1998 • 36 citations

Functional mapping of pain-related activation with echo-planar MRI

1998 • 35 citations

Address in Medicine

1889 • 32 citations

Neuronal responses in rabbit cingulate cortex linked to quick-phase eye movements during nystagmus

1988 • 27 citations

Representation of nociceptive stimuli in primary sensory cortex

1998 • 24 citations

Spinal processing: anatomy and physiology of spinal nociceptive mechanisms

1985 • 22 citations

Barr's the human nervous system :

2013 • 21 citations

Aδ afferent fiber stimulation activates descending noradrenergic system from the locus coeruleus

1998 • 18 citations

Responses of cat ventroposterolateral thalamic neurons to vibrotactile stimulation of forelimb footpads

1992 • 17 citations

Unilateral prefrontal lobotomy for the relief of intractable pain and termination of narcotic addiction.

1949 • 10 citations

Results of lobotomy.

1961 • 6 citations