Castration therapy rapidly induces apoptosis in a minority and decreases cell proliferation in a majority of human prostatic tumors.

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer.

1994 • 731 citations

Activation of Programmed Cell Death in the Rat Ventral Prostate after Castration*

1988 • 730 citations

Apoptosis and disease

1993 • 684 citations

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1993 • 597 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

Antagonistic effect of androgen on prostatic cell death

1984 • 339 citations

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

1992 • 317 citations

Deletion of cells by apoptosis during castration-induced involution of the rat prostate

1973 • 285 citations

Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: Androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 antigen revealed by antigen retrieval techniques

1994 • 271 citations

Bcl-2: a repressor of lymphocyte death

1992 • 217 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

Enhanced expression of the c‐myc protooncogene in high‐grade human prostate cancers

1987 • 192 citations

Androgen Regulation of Programmed Death of Normal and Malignant Prostatic Cells

1992 • 168 citations

Pathologic changes associated with androgen deprivation therapy for prostate cancer

1991 • 161 citations

Treatment of Stage IV Carcinoma of the Prostate

1975 • 123 citations

p53-Mediated Cell Death: Relationship to Cell Cycle Control

1993 • 98 citations

Therapy of prostatic cancer and histopathologic follow‐up

1982 • 59 citations

Myc-Mediated Apoptosis Is Blocked by Ectopic Expression of Bcl-2

1993 • 57 citations

Castration induces apoptosis in the ventral prostate but not in an androgen-sensitive prostatic adenocarcinoma in the rat.

1994 • 54 citations

Prostatic carcinoma: Problems in the interpretation of prostatic biopsies

1992 • 53 citations

Castration‐induced changes in morphology, androgen levels, and proliferative activity of human prostate cancer tissue grown in athymic nude mice

1993 • 46 citations

Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone

1992 • 44 citations

Castration rapidly results in a major reduction in epithelial cell numbers in the rat prostate, but not in the highly differentiated dunning R3327 prostatic adenocarcinoma

1993 • 41 citations

Estrogen treatment combined with castration inhibits tumor growth more effectively than castration alone in the dunning R3327 rat prostatic adenocarcinoma

1990 • 34 citations

Enhanced Expression of p53 mRNA and Protein in the Regressing Rat Ventral Prostate Gland

1994 • 27 citations

Deleted Work

1955 • 0 citations