Comparative Validation of Breast Cancer Risk Prediction Models and Projections for Future Risk Stratification

Assessing the Performance of Prediction Models

2009 • 3,795 citations

Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined Annually

1989 • 3,239 citations

Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk: A Meta-analysis

2006 • 1,991 citations

The personal and clinical utility of polygenic risk scores

2018 • 1,316 citations

Association analysis identifies 65 new breast cancer risk loci

2017 • 1,287 citations

A breast cancer prediction model incorporating familial and personal risk factors

2004 • 1,203 citations

Polygenic susceptibility to breast cancer and implications for prevention

2002 • 902 citations

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

2018 • 870 citations

Developing and evaluating polygenic risk prediction models for stratified disease prevention

2016 • 645 citations

Validation of the Gail et al. Model of Breast Cancer Risk Prediction and Implications for Chemoprevention

2001 • 607 citations

External validation of multivariable prediction models: a systematic review of methodological conduct and reporting

2014 • 591 citations

Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

2015 • 520 citations

Using Clinical Factors and Mammographic Breast Density to Estimate Breast Cancer Risk: Development and Validation of a New Predictive Model

2008 • 504 citations

Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies

2013 • 392 citations

Projecting Absolute Invasive Breast Cancer Risk in White Women With a Model That Includes Mammographic Density

2006 • 349 citations

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

2017 • 346 citations

Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States

2016 • 334 citations

Evaluation of breast cancer risk assessment packages in the family history evaluation and screening programme

2003 • 304 citations

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits

2018 • 270 citations

Collaborative Modeling of the Benefits and Harms Associated With Different U.S. Breast Cancer Screening Strategies

2016 • 252 citations

Mammographic Breast Density and the Gail Model for Breast Cancer Risk Prediction in a Screening Population

2005 • 241 citations

Validation of the Gail et al. Model for Predicting Individual Breast Cancer Risk

1994 • 236 citations

Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer

2018 • 223 citations

Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort

2015 • 217 citations

Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial

2016 • 211 citations

Practice Bulletin Number 179: Breast Cancer Risk Assessment and Screening in Average-Risk Women

2017 • 211 citations

The Contributions of Breast Density and Common Genetic Variation to Breast Cancer Risk

2015 • 196 citations

A systematic review of breast cancer incidence risk prediction models with meta-analysis of their performance

2011 • 173 citations

Long-term Accuracy of Breast Cancer Risk Assessment Combining Classic Risk Factors and Breast Density

2018 • 173 citations

Assessment of Clinical Validity of a Breast Cancer Risk Model Combining Genetic and Clinical Information

2010 • 167 citations

Breast cancer risk models: a comprehensive overview of existing models, validation, and clinical applications

2017 • 151 citations

Breast cancer risk prediction using a clinical risk model and polygenic risk score

2016 • 149 citations

10-year performance of four models of breast cancer risk: a validation study

2019 • 147 citations

Value of Adding Single-Nucleotide Polymorphism Genotypes to a Breast Cancer Risk Model

2009 • 134 citations

Predicting Risk of Breast Cancer in Postmenopausal Women by Hormone Receptor Status

2007 • 132 citations

Decision curve analysis revisited: overall net benefit, relationships to ROC curve analysis, and application to case-control studies

2011 • 130 citations

Constrained Maximum Likelihood Estimation for Model Calibration Using Summary-Level Information From External Big Data Sources

2016 • 130 citations

Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction

2018 • 129 citations

Risk prediction models of breast cancer: a systematic review of model performances

2011 • 116 citations

Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry

2015 • 111 citations

Combined Associations of Genetic and Environmental Risk Factors: Implications for Prevention of Breast Cancer

2014 • 110 citations

Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance

2012 • 108 citations

Tailoring Breast Cancer Screening Intervals by Breast Density and Risk for Women Aged 50 Years or Older: Collaborative Modeling of Screening Outcomes

2016 • 100 citations

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

2017 • 99 citations

Gail Model for Prediction of Absolute Risk of Invasive Breast Cancer: Independent Evaluation in the Florence–European Prospective Investigation Into Cancer and Nutrition Cohort

2006 • 92 citations

iCARE: An R package to build, validate and apply absolute risk models

2020 • 83 citations

Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I

2014 • 82 citations

Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials

2017 • 66 citations

The impact of a panel of 18 SNPs on breast cancer risk in women attending a UK familial screening clinic: a case–control study

2016 • 60 citations

SNPs and breast cancer risk prediction for African American and Hispanic women

2015 • 59 citations

Generalized meta-analysis for multiple regression models across studies with disparate covariate information

2019 • 58 citations

Effect of Changing Breast Cancer Incidence Rates on the Calibration of the Gail Model

2010 • 41 citations

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

2019 • 40 citations

Evaluating breast cancer risk projections for Hispanic women

2011 • 29 citations

Prospective validation of the NCI Breast Cancer Risk Assessment Tool (Gail Model) on 40,000 Australian women

2018 • 29 citations

Recalibration of the Gail model for predicting invasive breast cancer risk in Spanish women: a population-based cohort study

2013 • 25 citations

Assessing Breast Cancer Risk Models in Marin County, a Population With High Rates of Delayed Childbirth

2013 • 23 citations

Reproductive Factors and Mammographic Density: Associations Among 24,840 Women and Comparison of Studies Using Digitized Film-Screen Mammography and Full-Field Digital Mammography

2019 • 23 citations

Comparison of approaches for incorporating new information into existing risk prediction models

2016 • 13 citations

An assessment of existing models for individualized breast cancer risk estimation in a screening program in Spain

2013 • 9 citations