Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

2003 • 41,909 citations

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

2011 • 18,079 citations

Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

2013 • 12,861 citations

Comprehensive molecular portraits of human breast tumours

2012 • 10,753 citations

An integrated map of genetic variation from 1,092 human genomes

2012 • 7,751 citations

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

2014 • 7,539 citations

Integrative analysis of 111 reference human epigenomes

2015 • 6,134 citations

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

2012 • 5,361 citations

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

2015 • 4,930 citations

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

2015 • 4,725 citations

METAL: fast and efficient meta-analysis of genomewide association scans

2010 • 4,577 citations

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

2009 • 3,899 citations

An atlas of genetic correlations across human diseases and traits

2015 • 3,641 citations

Super-Enhancers in the Control of Cell Identity and Disease

2013 • 3,222 citations

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

2011 • 2,931 citations

Annotation of functional variation in personal genomes using RegulomeDB

2012 • 2,538 citations

Partitioning heritability by functional annotation using genome-wide association summary statistics

2015 • 2,414 citations

Genome-wide association study identifies novel breast cancer susceptibility loci

2007 • 2,342 citations

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

2010 • 2,083 citations

A promoter-level mammalian expression atlas

2014 • 1,919 citations

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

2010 • 1,868 citations

A linear complexity phasing method for thousands of genomes

2011 • 1,782 citations

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

2012 • 1,719 citations

Systematic identification of trans eQTLs as putative drivers of known disease associations

2013 • 1,635 citations

Matrix eQTL: ultra fast eQTL analysis via large matrix operations

2012 • 1,540 citations

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

2007 • 1,493 citations

A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

2011 • 1,457 citations

Association analysis identifies 65 new breast cancer risk loci

2017 • 1,287 citations

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

2013 • 1,051 citations

Pathway-Based Approaches for Analysis of Genomewide Association Studies

2007 • 855 citations

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk

2015 • 845 citations

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer

2007 • 793 citations

Analysing biological pathways in genome-wide association studies

2010 • 769 citations

Genome-wide association study identifies five new breast cancer susceptibility loci

2010 • 694 citations

A common coding variant in CASP8 is associated with breast cancer risk

2007 • 608 citations

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

2015 • 574 citations

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

2012 • 568 citations

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

2009 • 540 citations

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

2009 • 540 citations

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

2013 • 521 citations

Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

2015 • 520 citations

Bayesian refinement of association signals for 14 loci in 3 common diseases

2012 • 506 citations

The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions

2008 • 501 citations

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

2009 • 483 citations

Matrix eQTL: Ultra fast eQTL analysis via large matrix operations

2011 • 474 citations

Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments

2013 • 470 citations

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

2008 • 458 citations

Beta-Blocker Use Is Associated With Improved Relapse-Free Survival in Patients With Triple-Negative Breast Cancer

2011 • 420 citations

ProbABEL package for genome-wide association analysis of imputed data

2010 • 404 citations

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

2013 • 400 citations

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

2013 • 358 citations

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

2010 • 332 citations

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers

2016 • 327 citations

Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci

2013 • 309 citations

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

2011 • 299 citations

Genome-wide association analysis identifies three new breast cancer susceptibility loci

2012 • 277 citations

Global view of enhancer–promoter interactome in human cells

2014 • 263 citations

Novel Breast Cancer Susceptibility Locus at 9q31.2: Results of a Genome-Wide Association Study

2011 • 244 citations

Fast and accurate inference of local ancestry in Latino populations

2012 • 241 citations

Polygenic inheritance of breast cancer: Implications for design of association studies

2003 • 238 citations

Gene set analysis of genome-wide association studies: Methodological issues and perspectives

2011 • 206 citations

Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers

2013 • 204 citations

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

2012 • 174 citations

Genome-Wide Association Study in East Asians Identifies Novel Susceptibility Loci for Breast Cancer

2012 • 156 citations

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

2014 • 147 citations

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

2016 • 143 citations

A weighted cohort approach for analysing factors modifying disease risks in carriers of high‐risk susceptibility genes

2005 • 139 citations

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

2014 • 112 citations

Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

2013 • 108 citations

Cloning, Chromosomal Mapping, and Regulatory Properties of the Human Type 9 Adenylyl Cyclase (ADCY9)

1998 • 108 citations

Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1

2013 • 107 citations

19p13.1 Is a Triple-Negative–Specific Breast Cancer Susceptibility Locus

2012 • 103 citations

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

2016 • 102 citations

Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium

2011 • 98 citations

Genetic modifiers of cancer risk for BRCA1 and BRCA2 mutation carriers

2011 • 88 citations

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

2016 • 85 citations

A Genome-wide Association Study of Early-Onset Breast Cancer IdentifiesPFKMas a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age

2014 • 81 citations

Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

2014 • 81 citations

The β ₂ ^{‐adrenoceptor} activates a positive cAMP‐calcium feedforward loop to drive breast cancer cell invasion

2015 • 68 citations

Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3

2013 • 65 citations

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium

2014 • 56 citations

Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

2012 • 54 citations

Evaluating the power to discriminate between highly correlated SNPs in genetic association studies

2010 • 48 citations

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2

2015 • 42 citations

Evaluation of Association Methods for Analysing Modifiers of Disease Risk in Carriers of High‐Risk Mutations

2012 • 41 citations

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

2015 • 38 citations

F-BOX proteins in cancer cachexia and muscle wasting: Emerging regulators and therapeutic opportunities

2016 • 36 citations

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

2016 • 33 citations

Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells

2015 • 21 citations

Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription

2015 • 15 citations