Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial

1998 • 2,668 citations

Cancer statistics, 1998

1998 • 2,407 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial

1998 • 580 citations

Timed-sequential induction therapy improves postremission outcome in acute myeloid leukemia: a report from the Children's Cancer Group

1996 • 340 citations

Distinctive Demography, Biology, and Outcome of Acute Myeloid Leukemia and Myelodysplastic Syndrome in Children With Down Syndrome: Children's Cancer Group Studies 2861 and 2891

1998 • 315 citations

Cancer chemotherapy handbook

1980 • 283 citations

Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498 [see comments]

1992 • 264 citations

Autologous Bone Marrow Transplantation versus Intensive Consolidation Chemotherapy for Acute Myeloid Leukemia in Childhood

1996 • 262 citations

Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction.

1992 • 248 citations

Isolation of Human cDNAs That Restore Methotrexate Sensitivity and Reduced Folate Carrier Activity in Methotrexate Transport-defective Chinese Hamster Ovary Cells

1995 • 186 citations

Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87

1995 • 176 citations

Myelodysplasia and acute myelogenous leukemia in Down's syndrome. A report of 40 children of the AML-BFM Study Group.

1996 • 162 citations

Myelodysplasia and acute megakaryoblastic leukemia in down's syndrome

1994 • 153 citations

Cloning and expression of human deoxycytidine kinase cDNA.

1991 • 144 citations

Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study

1992 • 141 citations

Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia

1996 • 140 citations

Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.

1995 • 129 citations

Down's syndrome: A pathology involving the lack of balance of reactive oxygen species

1988 • 125 citations

Human cytoplasmic superoxide dismutase cDNA clone: a probe for studying the molecular biology of Down syndrome.

1982 • 95 citations

Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy.

1998 • 90 citations

Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome

1996 • 83 citations

A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.

1994 • 76 citations

Clinical and prognostic significance of trisomy 21 in adult patients with acute myelogenous leukemia and myelodysplastic syndromes.

1995 • 64 citations

Mechanism of cytosine arabinoside toxicity to the blast cells of acute myeloblastic leukemia: involvement of free radicals.

1995 • 53 citations

Trisomy 21 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study (8602)

1993 • 45 citations

Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity.

1991 • 41 citations

Favorable treatment outcome in children with acute myeloid leukemia and Down syndrome [letter; comment]

1993 • 36 citations

Slowed synthesis of DNA and methionine is a pathogenetic mechanism common to dementia in down's syndrome, AIDS and Alzheimer's disease?

1992 • 32 citations

The Molecular Genetics of Down Syndrome

1992 • 25 citations

Deletions of chromosome 21 restricted to the leukemic cells of children with Down syndrome and leukemia

1997 • 23 citations

Increased levels of a chromosome 21-encoded tumour invasion and metastasis factor(TIAM1) mRNA in bone marrow of down syndrome children during the acute phase of AML(M7)

1998 • 21 citations

7 Treatment of childhood acute myeloid leukaemia

1996 • 11 citations

[Phospholipid methylation in fibroblasts of patients with trisomy 21].

1987 • 2 citations

Modulation of cytosine arabinoside-induced proliferation inhibition by exogenous adenosylmethionine

1991 • 1 citations