Animal Mitochondrial DNA: An Extreme Example of Genetic Economy

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Rapid evolution of animal mitochondrial DNA.

1979 • 3,420 citations

tRNA punctuation model of RNA processing in human mitochondria

1981 • 2,386 citations

Nucleotide sequence of bacteriophage G4 DNA

1978 • 2,137 citations

Codon—anticodon pairing: The wobble hypothesis

1966 • 1,961 citations

Sequence and gene organization of mouse mitochondrial DNA

1981 • 1,712 citations

Mitochondrial DNA sequences of primates: Tempo and mode of evolution

1982 • 1,578 citations

Complete sequence of bovine mitochondrial DNA conserved features of the mammalian mitochondrial genome

1982 • 1,491 citations

Nucleotide sequence of bacteriophage φX174 DNA

1977 • 1,475 citations

Maternal inheritance of human mitochondrial DNA.

1980 • 1,327 citations

Evolution of genes and proteins.

1983 • 1,224 citations

Replication of animal mitochondrial DNA

1982 • 1,221 citations

The detection of DNA-binding proteins by protein blotting

1980 • 731 citations

The evolution of genes: the chicken preproinsulin gene

1980 • 725 citations

How ribosomes select initiator regions in mRNA: base pair formation between the 3' terminus of 16S rRNA and the mRNA during initiation of protein synthesis in Escherichia coli.

1975 • 690 citations

Maternal inheritance of mammalian mitochondrial DNA

1974 • 502 citations

Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis.

1980 • 485 citations

HUMAN MITOCHONDRIAL DNA VARIATION AND EVOLUTION: ANALYSIS OF NUCLEOTIDE SEQUENCES FROM SEVEN INDIVIDUALS

1983 • 449 citations

Mitochondrial Nucleic Acids

1972 • 433 citations

Sequence of the intron and flanking exons of the mitochondrial 21S rRNA gene of yeast strains having different alleles at the ω and rib-1 loci

1980 • 373 citations

Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows.

1982 • 370 citations

POLYMORPHIC SITES AND THE MECHANISM OF EVOLUTION IN HUMAN MITOCHONDRIAL DNA

1984 • 365 citations

Distinctive features of the 5′-terminal sequences of the human mitochondrial mRNAs

1981 • 355 citations

Mitochondrial DNA clones and matriarchal phylogeny within and among geographic populations of the pocket gopher, Geomys pinetis.

1979 • 330 citations

Purification and Properties of a Specific Escherichia coli Ribonuclease which Cleaves a Tyrosine Transfer Ribonucleic Acid Precursor

1972 • 318 citations

The tRNA genes punctuate the reading of genetic information in human mitochondrial DNA

1980 • 311 citations

The pattern of transcription of the human mitochondrial rRNA genes reveals two overlapping transcription units

1983 • 307 citations

Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA.

1982 • 303 citations

MITOCHONDRIAL DNA EVOLUTION IN MICE

1983 • 302 citations

Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code

1983 • 300 citations

Codon recognition rules in yeast mitochondria.

1980 • 293 citations

THE USE OF RESTRICTION ENDONUCLEASES TO MEASURE MITOCHONDRIAL DNA SEQUENCE RELATEDNESS IN NATURAL POPULATIONS. I. POPULATION STRUCTURE AND EVOLUTION IN THE GENUS PEROMYSCUS

1979 • 277 citations

Different pattern of codon recognition by mammalian mitochondrial tRNAs.

1980 • 272 citations

A Novel Closed-Circular Mitochondrial DNA with Properties of a Replicating Intermediate

1971 • 271 citations

Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNA

1983 • 268 citations

"Two out of three": an alternative method for codon reading.

1978 • 264 citations

Mapping of mitochondrial DNA of individual sheep and goats: Rapid evolution in the D loop region

1977 • 250 citations

Novel features in the genetic code and codon reading patterns in Neurospora crassa mitochondria based on sequences of six mitochondrial tRNAs

1980 • 248 citations

Number of mitochondria and some properties of mitochondrial DNA in the mouse egg

1976 • 237 citations

Evolutionary tree for apes and humans based on cleavage maps of mitochondrial DNA.

1981 • 220 citations

LENGTH MUTATIONS IN HUMAN MITOCHONDRIAL DNA

1983 • 205 citations

Replication of Mitochondrial DNA. Circular Replicative Intermediates in Mouse L Cells

1972 • 205 citations

Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable.

1981 • 203 citations

Maternal and cytoplasmic inheritance of mitochondrial DNA in Xenopus

1972 • 194 citations

Symmetrical In Vivo Transcription of Mitochondrial DNA in HeLa Cells

1971 • 188 citations

Extensive polymorphism in the mitochondrial DNA of apes.

1981 • 170 citations

Distinctive sequence of human mitochondrial ribosomal RNA genes

1980 • 169 citations

Location and structure of the var1 gene on yeast mitochondrial DNA: Nucleotide sequence of the 40.0 allele

1982 • 169 citations

Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication

1979 • 168 citations

Biogenesis of mitochondria: the mitochondrial gene (aap1) coding for mitochondrial ATPase subunit 8 inSaccharomyces cerevisiae

1983 • 158 citations

Expression of the mitochondrial genome in HeLa cells

1971 • 156 citations

Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance

1981 • 154 citations

Novel features of animal mtDNA evolution as shown by sequences of two rat cytochrome oxidase subunit II genes.

1982 • 154 citations

A Case of “Maternal” Inheritance in Neurospora Crassa

1952 • 153 citations

Ethnic variation in Hpa 1 endonuclease cleavage patterns of human mitochondrial DNA.

1981 • 146 citations

A mammalian mitochondrial serine transfer RNA lacking the “dihydrouridine” loop and stem

1980 • 135 citations

Nucleotide sequence ofAspergillus nidulansmitochondrial genes coding for ATPase subunit 6, cytochrome oxidase subunit 3, seven unidentified proteins, four tRNAs and L-rRNA

1982 • 135 citations

Mechanism of mRNA Recognition by Eukaryotic Ribosomes During Initiation of Protein Synthesis

1981 • 134 citations

Leaky +1 and −1 frameshift mutations at the same site in a yeast mitochondrial gene

1980 • 127 citations

Expression of the mitochondrial genome in HeLa cells

1971 • 121 citations

Lysis gene expression of RNA phage MS2 depends on a frameshift during translation of the overlapping coat protein gene

1982 • 120 citations

Kinetoplast RNA of Leishmania tarentolae

1978 • 119 citations

Origin and direction of replication in mitochondrial DNA molecules from the genus Drosophila.

1980 • 118 citations

Drosophilamitochondrial DNA: a novel gene order

1982 • 117 citations

Fractionation of mitochondrial RNA from HeLa cells by high-resolution electrophoresis under strongly denaturing conditions

1978 • 115 citations

Specific cleavage analysis of mammalian mitochondrial DNA.

1975 • 113 citations

The mitochondrial genome of wild-type yeast cells

1977 • 107 citations

Mitochondrial polyadenylic acid-containing RNA: Localization and characterization

1973 • 107 citations

Origin and direction of replication in mitochondrial DNA molecules from Drosophila melanogaster.

1978 • 107 citations

Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA

1980 • 107 citations

Identification of the Chloramphenicol-Binding Protein in Escherichia coli Ribosomes by Partial Reconstitution

1973 • 106 citations

Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA.

1981 • 106 citations

Isolation, subunit composition, and site of synthesis of human cytochrome c oxidase

1980 • 104 citations

Expression of the mitochondrial genome in xenopus laevis: a map of transcripts

1979 • 89 citations

Characterization and mapping of mitochondrial ribosomal RNA and mitochondrial DNA in Drosophila melanogaster

1976 • 89 citations

The mitochondrial genome of wild-type yeast cells

1974 • 87 citations

Evolution of mitochondrial DNA sequences in Xenopus

1972 • 86 citations

Extensive diversity among Drosophila species with respect to nucleotide sequences within the adenine + thymine-rich region of mitochondrial DNA molecules

1980 • 85 citations

Genes for cytochromecoxidase subunit I, URF2, and three tRNAs inDrosophilamitochondrial DNA

1983 • 82 citations

Evidence for complete symmetrical transcription in vivo of mitochondrial DNA in HeLa cells

1975 • 80 citations

Different nucleotide changes in the large rRNA gene of the mitochondrial DNA confer chloramphenicol resistance on two human cell lines

1981 • 79 citations

The nucleotide sequence of a small (3S) seryl-tRNA (anticodon GCU) from beef heart mitochondria

1980 • 79 citations

The presence of DNA molecules with a displacement loop in standard mitochondrial DNA preparations

1971 • 78 citations

The nucleotide sequence of the large ribosomal RNA gene and the adjacent tRNA genes from rat mitochondria

1981 • 76 citations

Sequence analysis and precise mapping of the 3′ ends of HeLa cell mitochondrial ribosomal RNAs

1982 • 74 citations

Transcription of kinetoplast DNA in Trypanosoma brucei bloodstream and culture forms

1981 • 73 citations

Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II and III, ATPase subunit 6, and several tRNA genes

1981 • 70 citations

Antibodies against synthetic peptides reveal that the unidentified reading frame A6L, overlapping the ATPase 6 gene, is expressed in human mitochondria

1983 • 70 citations

Methylated regions of hamster mitochondrial ribosomal RNA: structural and functional correlates

1981 • 70 citations

Cytochrome oxidase subunit III gene in Neurospora crassa mitochondria. Location and sequence.

1982 • 69 citations

The sequences of the small ribosomal RNA gene and the phenylalanine tRNA gene are joined end to end in human mitochondrial DNA

1980 • 68 citations

A small polyadenylated RNA (7 S RNA), containing a putative ribosome attachment site, maps near the origin of human mitochondrial DNA replication

1981 • 68 citations

Amino acid change associated with the major polymorphic Hinc II site of Oriental and Caucasian mitochondrial DNAs.

1983 • 68 citations

Expression of the mitochondrial genome in HeLa cells

1974 • 62 citations

Nucleotide sequences of small ribosomal RNA and adjacent transfer RNA genes in rat mitochondrial DNA

1981 • 61 citations

Intercalating drugs and low temperatures inhibit synthesis and processing of ribosomal RNA in isolated human mitochondria

1984 • 60 citations

The restriction fragment map of rat-liver mitochondrial DNA: A reconsideration

1977 • 60 citations

Amino acid specificity of the transfer RNA species coded for by HeLa cell mitochondrial DNA

1976 • 58 citations

Nucleotide sequence of a segment ofDrosophilamitochondrial DNA that contains the genes for cytochromecoxidase subunits II and III and ATPase subunit 6

1983 • 58 citations

Protection of specific sites in 23 S and 5 S RNA from chemical modification by association of 30 S and 50 S ribosomes

1979 • 58 citations

Nucleotide sequence of a region of the mitochondrial genome ofAspergillus nidulansincluding the gene for ATPase subunit 6

1982 • 57 citations

Ribonuclease P substrate specificity: cleavage of a bacteriophage phi80-induced RNA.

1976 • 57 citations

The heterogeneity of rat-liver mitochondrial DNA

1978 • 56 citations

Mapping of mitochondrial DNA in Xenopus laevis and X. borealis: The positions of ribosomal genes and D-loops

1978 • 54 citations

Identification of the polypeptides encoded in the ATPase 6 gene and in the unassigned reading frames 1 and 3 of human mtDNA.

1983 • 52 citations

The mitochondnal genome of Aspergillus nidulans contains reading frames homologous to the human URFs 1 and 4.

1983 • 48 citations

Nucleotide sequence of a cloned fragment of rat mitochondrial DNA containing the replication origin

1980 • 47 citations

Failure to detect “cap” structures in mitochondrial DNA-coded poly(A)-containing RNA from HeLa cells

1978 • 46 citations

Modification of mitochondrial ribosomal RNA from hamster cells: The presence of GmG and late-methylated UmGmU in the large subunit (17 S) RNA

1978 • 46 citations

High-resolution electrophoretic fractionation and partial characterization of the mitochondrial translation products from HeLa cells

1982 • 46 citations

Assignment of a polymorphic polypeptide to the human mitochondrial DNA unidentified reading frame 3 gene by a new peptide mapping strategy.

1983 • 46 citations

Endogenous synthesis of formyl-methionine peptides in isolated mitochondria and chloroplasts

1971 • 46 citations

Transfer RNA genes inDrosophilamitochondrial DNA: related 5' flanking sequences and comparisons to mammalian mitochondrial tRNA genes

1983 • 45 citations

The 3′ terminus of the large ribosomal subunit (“17S”) RNA from hamster mitochondria is ragged and oligoadenylated

1981 • 45 citations

Methylation status of 13S ribosomal RNA from hamster mitochondria: the presence of a novel riboside, N⁴-methylcytidine

1978 • 43 citations

Mitochondrial DNA in Drosophila

1981 • 42 citations

Identification of the 3‘-ends of the two mouse mitochondrial ribosomal RNAs. The 3‘-end of 16 S ribosomal RNA contains nucleotides encoded by the gene for transfer RNALeuUUR.

1983 • 41 citations

The occurrence of two types of mitochondrial DNA in rat populations as detected by EcoRI endonuclease analysis

1977 • 41 citations

Nucleotide assignment of alkali-sensitive sites in mouse mitochondrial DNA.

1981 • 37 citations

Mitochondrial protein synthesis in mouse L-cells: Effect of selective nicking of mitochondrial DNA

1975 • 37 citations

Mitochondrial RNA and protein synthesis in enucleated African green monkey cells

1978 • 34 citations

Transcription of Mitochondrial DNA

1983 • 31 citations

The 3′-terminal region of mosquito mitochondrial small ribosomal subunit RNA: Sequence and localization of methylated residues

1983 • 30 citations

A cluster of six tRNA genes inDrosophilamitochondrial DNA that includes a gene for an unusual tRNA^ser_AGY

1984 • 30 citations

Sequence and structure of a serine transfer RNA with GCU anticodon from mosquito mitochondria

1984 • 27 citations

Mitochondrial DNA polymorphism: evidence that variants detected by restriction enzymes differ in nucleotide sequence rather than in methylation.

1980 • 26 citations

A major lysine tRNA with a CUU anticodon in insect mitochondria

1983 • 25 citations

Mapping of mitochondrial 4S RNA genes in Xenopus laevis by electron microscopy

1978 • 23 citations

Alignment of the amino terminal amino acid sequence of human cytochrome c oxidase subunits I and II with the sequence of their putative mRNAs

1981 • 22 citations

The nucleotide sequences of several tRNA genes from rat mitochondria: common features and relatedness to homologous species

1982 • 22 citations

Mammalian mitochondrial transfer RNAs: chromatographic properties, size and origin

1979 • 21 citations

Comparison of sea urchin and human mtDNA: evolutionary rearrangement.

1983 • 18 citations

Rat liver mitochondrial lysine tRNA (anticodon U∗UU) contains a rudimentary D-ARM and 2 hypermodified nucleotides in its anticodon loop

1981 • 17 citations

Nucleotide sequence variants of Rattus norvegicus mitochondrial DNA

1981 • 17 citations

Fragmentary 5S rRNA gene in the human mitochondrial genome.

1982 • 16 citations

Comparison of human and hamster mitochondrial transfer RNA Physical properties and methylation status

1976 • 16 citations

tRNA genes in rat liver mitochondrial DNA

1981 • 14 citations

Sequences around the 3′-end of a ribosomal RNA gene of hamster mitochondria

1984 • 14 citations

Origin of the actinomycin D insensitive RNA species in Aedes albopictus cells

1978 • 11 citations