Modulation of cell function in the calcium messenger system

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Mechanisms of action of transmitters and other substances on smooth muscle.

1979 • 2,193 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Nerve, Muscle and Synapse

1966 • 1,431 citations

Cell Communication, Calcium Ion, and Cyclic Adenosine Monophosphate

1970 • 1,097 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

Calmodulin—an intracellular calcium receptor

1980 • 964 citations

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

Cyclic 3′,5′-nucleotide phosphodiesterase

1970 • 824 citations

FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE BY TISSUE PARTICLES

1958 • 802 citations

Control of muscle contraction

1969 • 785 citations

Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process

1973 • 631 citations

Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle.

1981 • 572 citations

Calcium transport in contraction and secretion

1975 • 567 citations

Cyclic 3',5'-Nucleotide Phosphodiesterase

1971 • 531 citations

MITOCHONDRIAL CALCIUM OVERLOAD: A GENERAL MECHANISM FOR CELL-NECROSIS IN MUSCLE DISEASES

1976 • 494 citations

Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain

1970 • 491 citations

Conformational transition accompanying the binding of calcium(2+) ion to the protein activator of 3',5'-cyclic adenosine monophosphate phosphodiesterase

1977 • 472 citations

Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations

1979 • 454 citations

The interaction of cyclic nucleotides and calcium in the control of cellular activity.

1975 • 451 citations

Mechanism of Activation of a Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase from Bovine Heart by Calcium Ions

1973 • 444 citations

Hormonal effects on calcium homeostasis in isolated hepatocytes.

1980 • 441 citations

The Regulation of Skeletal Muscle Phosphorylase Kinase by Ca2+

1971 • 416 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

Ionized calcium concentrations in squid axons.

1976 • 358 citations

Excitation-Contraction Coupling

1976 • 355 citations

A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle.

1977 • 344 citations

Positive cooperative binding of calcium to bovine brain calmodulin

1980 • 334 citations

Control, modulation, and regulation of cell calcium

1981 • 330 citations

Activation of skeletal muscle myosin light chain kinase by calcium(2+) and calmodulin

1980 • 326 citations

Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes. Theoretical approach to study of multiple ligand binding to a macromolecule

1981 • 321 citations

Cyclic AMP and contractile activity in heart.

1977 • 291 citations

Calcium and cAMP as synarchic messengers

1982 • 284 citations

Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

1979 • 284 citations

The Role of Calmodulin in the Structure and Regulation of Phosphorylase Kinase from Rabbit Skeletal Muscle

1979 • 267 citations

Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart

1978 • 264 citations

Third Component Participating in the Super precipitation of ‘Natural Actomyosin’

1963 • 264 citations

Regulation of free Ca2+ by liver mitochondria and endoplasmic reticulum.

1980 • 255 citations

Calmodulin and Its Role in the Second-Messenger System

1979 • 240 citations

Excitation-contraction coupling in cardiac muscle

1980 • 227 citations

Cyclic Nucleotides, Phosphorylated Proteins, And Neuronal Function

1978 • 216 citations

Effects of adenosine 3':5'-monophosphate-dependent protein kinase on sarcoplasmic reticulum isolated from cardiac and slow and fast contracting skeletal muscles.

1976 • 189 citations

Phosphorylation of the inhibitory subunit of troponin and its effect on the calcium dependence of cardiac myofibril adenosine triphosphatase

1976 • 188 citations

Evolutionary diversification of structure and function in the family of intracellular calcium-binding proteins

1979 • 188 citations

Troponin C-like proteins (calmodulins) from mammalian smooth muscle and other tissues

1979 • 177 citations

The calmodulin hypothesis of neurotransmission

1981 • 161 citations

The effect of Ca2+ on the oxidation of glycerol phosphate by blowfly flight-muscle mitochondria

1967 • 154 citations

Correlation between contraction and phosphorylation of the inhibitory subunit of troponin in perfused rat heart

1975 • 151 citations

METALLOCHROMIC INDICATORS OF IONIZED CALCIUM

1978 • 150 citations

alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.

1982 • 143 citations

Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the binding of four Ca2+ to calmodulin for activation.

1981 • 123 citations

Physiological and bioenergetic aspects of mitochondrial calcium transport

1983 • 122 citations

The modulator-dependent protein kinase. A multifunctional protein kinase activatable by the Ca2+-dependent modulator protein of the cyclic nucleotide system.

1978 • 114 citations

THE REGULATION OF INTRACELLULAR CALCIUM IN GIANT AXONS OF LOLIGO AND MYXICOLA

1978 • 103 citations

Studies of the Ca2+ transport mechanism of human erythrocyte inside-out plasma membrane vesicles. I. Regulation of the Ca2+ pump by calmodulin.

1981 • 98 citations

Mitochondria and other calcium buffers of squid axon studied in situ.

1978 • 95 citations

Rabbit skeletal muscle phosphorylase kinase. Comparison of glycogen synthase and phosphorylase as substrates.

1979 • 93 citations

Effects of Parathyroid Hormone on the Distribution and Transport of Calcium in Cultured Kidney Cells*

1978 • 84 citations

CRYSTALLOGRAPHIC STUDIES OF CALMODULIN AND HOMOLOGS

1980 • 77 citations

Reversible inhibition of cyclic AMP-dependent protein kinase by insulin

1978 • 77 citations

CALMODULIN AND THE PLASMA MEMBRANE CALCIUM PIIMP*

1980 • 76 citations

Mitochondria and disease

1980 • 74 citations

Phosphorylation by cyclic adenosine 3':5'-monophosphate-dependent protein kinase regulates myosin light chain kinase.

1980 • 74 citations

Calmodulin — And its role in cellular activation

1981 • 71 citations

Calcium-activated tension: the role of myosin light chain phosphorylation.

1980 • 68 citations

Biochemical regulation and physiological significance of cyclic nucleotides in the nervous system.

1977 • 67 citations

STRUCTURE AND FUNCTION RELATIONSHIPS AMONG CALMODULINS AND TROPONIN C‐LIKE PROTEINS FROM DIVERGENT EUKARYOTIC ORGANISMS*

1980 • 65 citations

REGULATION OF MYOSIN LIGHT CHAIN KINASE BY REVERSIBLE PHOSPHORYLATION AND CALCIUM‐CALMODULIN

1980 • 60 citations

Cyclic AMP-dependent protein kinase I: Cyclic nucleotide binding, structural changes, and release of the catalytic subunits

1981 • 59 citations

Messenger role of calcium in function of pancreatic acinar cells

1980 • 59 citations

The Hormonal Control of Glycogen Metabolism in Mammalian Muscle by Multivalent Phosphorylation

1979 • 55 citations

Stimulation of phosphorylase b kinase by the calcium-dependent regulator.

1980 • 52 citations

CALCIUM AND CAMP IN STIMULUS‐RESPONSE COUPLING*

1980 • 52 citations

ROLE OF CALMODULIN IN DOPAMINERGIC TRANSMISSION

1980 • 50 citations

ON THE MECHANISM OF ACTIVATION OF CYCLIC NIJCLEOTIDE PHOSPHODIESTERASE BY CALMODULIN

1980 • 49 citations

Calcium Regulation During Stimulus-Secretion Coupling: Continuous Measurement of Intracellular Calcium Activities

1980 • 49 citations

Bovine heart protein activator of cyclic nucleotide phosphodiesterase.

1975 • 47 citations

THE REGULATORY ROLE OF CALCIUM IN MUSCLE*

1978 • 45 citations

CONNECTIVE TISSUE‐DEGRADING ENZYMES OF HUMAN LEUKOCYTES

1975 • 45 citations

CALMODULIN REGULATION OF THE Ca²⁺ PUMP OF ERYTHROCYTE MEMBRANES*

1980 • 42 citations

CALCIUM ION REGULATION IN BARNACLE MUSCLE FIBERS AND ITS RELATION TO FORCE DEVELOPMENT

1978 • 40 citations

Preliminary measurements of intracellular calcium in an insect salivary gland using a calcium-sensitive microelectrode

1980 • 39 citations

Ca2+, calmodulin and cycic AMP-dependent modulation of actin-myosin interactions in aorta

1981 • 36 citations

The Messenger Function of Calcium in Endocrine Systems

1981 • 35 citations

Changes in Calcium Transport Across Calliphora Salivary Glands Induced by 5-Hydroxytryptamine and Cyclic Nucleotides

1979 • 34 citations

Ca²⁺ REGULATION OF CYCLIC NUCLEOTIDE METABOLISM*

1980 • 33 citations

Control of pancreatic cyclic nucleotide levels and amylase secretion by noncholinergic, nonadrenergic nerves. A study employing electrical field stimulation of guinea pig segments.

1981 • 33 citations

Drug-Induced Changes in Cardiac Energy

2015 • 29 citations

Cyclic nucleotides in central synaptic function.

1979 • 25 citations

Phosphorylated cardiac myofibrils and their effect on ATPase activity

1978 • 24 citations

PHOSPHORYLATION OF MYOSIN AS A REGULATORY COMPONENT IN SMOOTH MUSCLE*

1980 • 23 citations

cAMP renders Ca2+-dependent phosphodiesterase refractory to inhibition by a calmodulin-binding protein (calcineurin).

1981 • 18 citations

Regulation of cyclic AMP metabolism in the rat erythrocyte during chronicβ-adrenergic stimulation. Evidence for calmodulin-mediated alteration of membrane-bound phosphodiesterase activity

1981 • 17 citations

COMPARATIVE BIOCHEMISTRY OF CALMODULINS AND CALMODULIN‐LIKE PROTEINS*

1980 • 15 citations

Cathleen Morawetz: The Mathematics of Waves

1979 • 11 citations