The calmodulin hypothesis of neurotransmission

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

1979 • 1,408 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

The separation of synaptic vesicles from nerve-ending particles (‘synaptosomes’)

1964 • 1,213 citations

The role of calcium in the release of neurotransmitter substances and hormones.

1970 • 871 citations

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

Antiepileptic drugs : mechanisms of action

1980 • 508 citations

Structural changes after transmitter release at the frog neuromuscular junction.

1981 • 471 citations

Further study of the role of calcium in synaptic transmission

1970 • 461 citations

Transmitter release induced by injection of calcium ions into nerve terminals

1973 • 443 citations

Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

1977 • 393 citations

The effect of magnesium on the activity of motor nerve endings

1954 • 378 citations

Spontaneous and evoked activity of motor nerve endings in calcium Ringer

1969 • 352 citations

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

1978 • 346 citations

Stimulation of Ca ²⁺ -dependent neurotransmitter release and presynaptic nerve terminal protein phosphorylation by calmodulin and a calmodulin-like protein isolated from synaptic vesicles

1979 • 346 citations

PHARMACOLOGICAL REGULATION OF CALMODULIN*

1980 • 341 citations

Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein

1978 • 332 citations

Presence of calmodulin in postsynaptic densities isolated from canine cerebral cortex.

1979 • 208 citations

The action of calcium on neuronal synapses in the squid

1966 • 204 citations

Calcium-Dependent Norepinephrine Release from Presynaptic Nerve Endings In Vitro

1972 • 187 citations

Calmodulin in neurotransmitter release and synaptic function.

1982 • 172 citations

Tubulin: An Integral Protein of Mammalian Synaptic Vesicle Membranes

1980 • 156 citations

MICROTUBULE PROTEIN

1971 • 153 citations

ROLE OF CALMODULIN IN NEUROTRANSMITTER RELEASE AND SYNAPTIC FUNCTION*

1980 • 125 citations

Benzodiazepine Inhibition of the Calcium-Calmodulin Protein Kinase System in Brain Membrane

1981 • 115 citations

Calcium dependent neurotransmitter release and protein phosphorylation in synaptic vesicles

1978 • 109 citations

Synaptic Macromolecules: Identification and Metabolism

1974 • 102 citations

Phosphorylation of Adrenal Medulla Cell Proteins in Conjunction with Stimulation of Catecholamine Secretion

1981 • 99 citations

Calcium-dependent phosphorylation of specific synaptosomal fraction proteins: Possible role of phosphoproteins in mediating neurotransmitter release

1976 • 82 citations

ISOLATION OF COATED VESICLES, PLAIN SYNAPTIC VESICLES, AND FLOCCULENT MATERIAL FROM A CRUDE SYNAPTOSOME FRACTION OF GUINEA PIG WHOLE BRAIN

1973 • 73 citations

Phosphorylation and dephosphorylation of membrane proteins as a possible mechanism for structural rearrangement of membrane components

1976 • 72 citations

THE PRESENCE AND FUNCTIONS OF CALMODULIN IN THE POSTSYNAPTIC DENSITY

1980 • 64 citations

Calcium-dependent phosphorylation of synaptic vesicle proteins and its possible role in mediating neurotransmitter release and vesicle function

1977 • 62 citations

REGULATION OF THE LEVEL OF ENDOGENOUS PHOSPHORYLATION OF SPECIFIC BRAIN PROTEINS BY DIPHENYLHYDANTOIN¹

1977 • 59 citations

Antagonistic action of diphenylhydantoin and calcium on the level of phosphorylation of particular rat and human brain proteins

1977 • 47 citations

Ca2+-dependent protein phosphorylation of purely cholinergic Torpedo synaptosomes.

1979 • 39 citations

Modulators, Mediators, and Specifiers in Brain Function

1979 • 38 citations

Possible Role of Calcium‐Dependent Protein Phosphorylation in Mediating Neurotransmitter Release and Anticonvulsant Action

1977 • 32 citations

Effect of diphenylhydantoin on the endogenous phosphorylation of brain protein

1976 • 31 citations

Phenytoin: calcium- and calmodulin-dependent protein phosphorylation and neurotransmitter release.

1980 • 29 citations

IMMUNOCYTOCHEMICAL LOCALIZATION OF CALMODULIN IN REGIONS OF RODENT BRAIN*

1980 • 28 citations

Phosphoproteins as Specifiers for Mediators and Modulators in Neuronal Function

1979 • 23 citations

Phosphorylation of Synaptic Membranes

1980 • 23 citations

Regulatory mechanisms of synaptic transmission

1982 • 5 citations