Hypnotic Medications: Mechanisms of Action and Pharmacologic Effects

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Benzodiazepine Receptor: Demonstration in the Central Nervous System

1977 • 1,705 citations

Benzodiazepine receptors in rat brain

1977 • 1,459 citations

Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness

1997 • 1,198 citations

Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

1999 • 1,154 citations

Prevalence, burden, and treatment of insomnia in primary care

1997 • 676 citations

Histamine-immunoreactive nerve fibers in the rat brain

1989 • 631 citations

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

1981 • 559 citations

Quantitative receptor autoradiography using [3H]Ultrofilm: application to multiple benzodiazepine receptors

1982 • 529 citations

The organization of neural inputs to the medial preoptic nucleus of the rat

1986 • 516 citations

Zolpidem

1990 • 290 citations

Sleep-related neuronal discharge in the basal forebrain of cats

1986 • 264 citations

Hypnotics and sedatives; ethanol

1996 • 254 citations

Zopiclone

1998 • 250 citations

Epidemiology Of Alcohol and Medication As Aids To Sleep in Early Adulthood

1998 • 246 citations

Neurotransmitter specificity of cells and fibers in the medial preoptic nucleus: An immunohistochentical study in the rat

1986 • 233 citations

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture.

1989 • 216 citations

Effect of flurazepam on sleep-disordered breathing and nocturnal oxygen desaturation in asymptomatic subjects

1982 • 213 citations

Structure and Pharmacology of Vertebrate GABAA Receptor Subtypes

1995 • 212 citations

Tolerance to Daytime Sedative Effects of H1 Antihistamines

2002 • 205 citations

Glutamate decarboxylase (GAD) and γ-aminobutyric acid (GABA) in discrete nuclei of hypothalamus and substantia nigra

1977 • 198 citations

Role of adenosine in sleep and temperature regulation in the preoptic area of rats

1991 • 182 citations

Preoptic Catecholamine, GABA, and Glutamate Release in Ovariectomized and Ovariectomized Estrogen-Primed Rats Utilizing a Push-Pull Cannula Technique

1985 • 143 citations

The treatment of chronic insomnia: drug indications, chronic use and abuse liability. Summary of a 2001 New Clinical Drug Evaluation Unit Meeting Symposium

2003 • 142 citations

Brain mechanisms of sleep

1985 • 142 citations

Hypothalamo‐preoptic Histaminergic Projections in Sleep‐Wake Control in the Cat

1994 • 141 citations

Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland

1986 • 132 citations

An analysis of histaminergic efferents of the tuberomammillary nucleus to the medial preoptic area and inferior colliculus of the rat

1990 • 129 citations

Firing of neurons in the preoptic/anterior hypothalamic areas in rat: its possible involvement in slow wave sleep and paradoxical sleep

1994 • 118 citations

The Effect of Triazolam on Arousal and Respiration in Central Sleep Apnea Patients

1990 • 107 citations

Pharmacological Treatment of Insomnia

1993 • 76 citations

Human Sleep: Research and Clinical Care

1987 • 73 citations

Comparison of short and long half-life benzodiazepine hypnotics: Triazolam and quazepam

1986 • 67 citations

Prevalence of insomnia: a survey of the enrollees at five managed care organizations.

1998 • 66 citations

Melatonin-induced depression of locomotor activity in hamsters: Time-dependency and inhibition by the central-type benzodiazepine antagonist Ro 15-1788

1991 • 63 citations

Depression of central respiratory drive by nitrazepam.

1978 • 51 citations

α Subunit isoform influences GABAA receptor modulation by propofol

1997 • 50 citations

Efficacy of a reduced triazolam dose in elderly insomniacs

1985 • 49 citations

Sleep-inducing effects of adenosine microinjections into the medial preoptic area are blocked by flumazenil

2000 • 48 citations

Neuropharmacology of sleep induction by benzodiazepines.

1992 • 46 citations

Neuronal sensitivities in preoptic tissue slices: Interactions among homeostatic systems

1988 • 44 citations

Characterization of the hypnotic effects of triazolam microinjections into the medial preoptic area

1992 • 43 citations

A Critical Evaluation of the Hypnotic Efficacy of Melatonin

1997 • 41 citations

Sleep Evaluation in Chronic Insomniacs during 14-Day Use

1990 • 40 citations

Effects of Flurazepam and Zolpidem on the Perception of Sleep in Insomniacs

1995 • 39 citations

Brain Mechanisms of Sleep

1986 • 39 citations

Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.

1998 • 34 citations

Melatonin microinjection into the medial preoptic area increases sleep in the rat

2002 • 33 citations

Adverse Reactions to Sedative/Hypnotics: Three Years’ Experience

1996 • 30 citations

Effects of Zolpidem, Codeine Phosphate and Placebo on Respiration

1993 • 26 citations

Effects of Flurazepam and Zolpidem on the Perception of Sleep in Normal Volunteers

1995 • 25 citations

Effects of ethanol injection to the preoptic area on sleep and temperature in rats

1992 • 24 citations

Dose effects of temazepam tablets on sleep.

1986 • 24 citations

Pharmacologic Alteration of the Perception of Being Awake or Asleep

1993 • 23 citations

Clinical Neuropharmacology of Sleep

1990 • 14 citations

Sleep inducing effects of propofol microinjection into the medial preoptic area are blocked by flumazenil

2001 • 12 citations

Room D, 10/17/2000 2: 00 PM - 4: 00 PM (PS) Flumazenil Blocks the Increase in Sleep after Propofol Microinjection into the Medial Preoptic Area of the Rat

2000 • 3 citations