Biological Alkylating Agents

The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine

1956 • 877 citations

The Physiopathology of Cancer

1959 • 312 citations

Differences between the Electrical Charge carried by Normal and Homologous Tumour Cells

1956 • 259 citations

Biological Alkylating Agents

1962 • 209 citations

112. The methylation of adenosine and adenylic acid

1960 • 168 citations

Cyto-active amino-acid and peptide derivatives. Part I. Substituted phenylalanines

1954 • 163 citations

Synthese und Abbau cytostatisch wirksamer cyclischer N‐Phosphamidester des Bis‐(β‐chloräthyl)‐amins

1958 • 161 citations

The Chemistry of Cytotoxic Alkylating Agents

1953 • 153 citations

THE REACTIONS OF THE “RADIOMIMETIC” ALKYLATING AGENTS WITH MACROMOLECULES IN VITRO

1958 • 143 citations

Preparation of N-Phosphorylated Derivatives of Bis-β-chloroethylamine^1a

1954 • 137 citations

Neuartige Krebs-Chemotherapeutika aus der Gruppe der zyklischen N-Lost-Phosphamidester

1958 • 118 citations

486. Aryl-2-halogenoalkylamines. Part XII. Some carboxylic derivatives of NN-di-2-chloroethylaniline

1953 • 117 citations

CARCINOGENIC ACTION OF ALKYLATING AGENTS

1958 • 116 citations

IN VITRO REACTIONS OF BIOLOGICAL ALKYLATING AGENTS

1958 • 110 citations

Effects upon tumours of Various Haloalkylarylamines

1948 • 100 citations

Synthese einfacher Chinon‐Derivate mit fungiziden, bakteriostatischen oder cytostatischen Eigenschaften

1955 • 92 citations

Experiences with Isolation-Perfusion Technics in the Treatment of Cancer

1959 • 89 citations

Cytogenetic analysis of the action of carcinogens and tumour inhibitors inDrosophila melanogaster V. Differential genetic response to the alkylating mutagens and x-radiation

1956 • 87 citations

STUDIES ON THE ANTI-TUMOUR ACTIVITY OF p-DI-(2-CHLOROETHYL) AMINOPHENYLALANINE (SARCOLYSINE)

1955 • 87 citations

New Cytotoxic Agents with Tumour-Inhibitory Activity

1950 • 83 citations

CHEMICAL CARCINOGENS AND THEIR MODES OF ACTION

1958 • 76 citations

INACTIVATION AND UNSTABILIZATION OF THE TRANSFORMING PRINCIPLE BY MUTAGENIC AGENTS

1956 • 75 citations

The Plasmagene Theory of the Origin of Cancer

1948 • 68 citations

The relative reactivities of deoxyribonucleotides and of the bases of DNA towards alkylating agents

1957 • 68 citations

Studies on the mode of action of tumour-growth-inhibiting alkylating agents—I

1958 • 66 citations

Effect of Ionizing Radiation on Aqueous Solutions of Guanylic Acid and Guanosine

1958 • 66 citations

Reduction of Cytotoxic Azo Compounds by Hydrazine and by the Xanthine Oxidase–Xanthine System

1955 • 64 citations

HEMATOLOGICAL EFFECTS OF THE ALKYLATING AGENTS

1958 • 60 citations

Mode of Action of Alkylating Agents: Formation of S-Ethylcysteine from Ethyl Methanesulphonate In Vivo

1957 • 49 citations

REACTION OF BISCYCLOPENTADIENYLCOBALT(II) WITH ORGANIC HALIDES

1958 • 48 citations

Specific Reactions of Polyelectrolytes with the Surfaces of Normal and Tumour Cells

1958 • 47 citations

5-BIS-(2-CHLOROETHYL)-AMINOURACIL, A NEW ANTITUMOR AGENT

1958 • 45 citations

Weitere Untersuchungen über Äthylenimino-chinone und verwandte Verbindungen

1957 • 43 citations

The relation of anticancer activity to chemical structure: a review.

1959 • 42 citations

PERFUSION TREATMENT OF PATIENTS WITH CANCER

1959 • 41 citations

151. Synthesis of new sugar derivatives of potential antitumour activity. Part I. Ethyleneimino- and 2-chloroethylamino-derivatives

1957 • 38 citations

Malignant melanoma of the extremities: Experiences with conventional therapy; a new surgical and chemotherapeutic approach with regional perfusion

1960 • 36 citations

Metabolic and Chemical Studies of ‘Myleran’: Formation of 3-Hydroxytetrahydrothiophene-1,1-Dioxide In Vivo, and Reactions With Thiols In Vitro

1959 • 34 citations

Metabolism of Myleran (1 : 4-Dimethanesulphonyloxybutane)

1959 • 34 citations

Effect of a Series of Ethylenimine Derivatives against Metastasizing Mammary Adenocarcinoma of the Rat

1952 • 32 citations

Aryl-2-halogenoalkylamines. Part XIV. Some compounds possessing latent cytotoxic activity

1955 • 31 citations

610. The preparation of some cytotoxic epoxides

1950 • 31 citations

Nitrogen Mustard Analogs of Antimalarial Drugs¹

1959 • 31 citations

Inhibition Studies of Some Phosphoramides Against Sarcoma 180.

1951 • 30 citations

‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents

1959 • 27 citations

Treatment of Malignant Tumors of the Extremities by Perfusion with Chemotherapeutic Agents

1959 • 26 citations

Über die Umsetzung einiger Alkoxy‐p‐benzochinone mit Äthylenimin

1958 • 26 citations

Potential Anticancer Agents.¹ XVII. Alkylating Agents to Phenylalanine Mustard. I.

1959 • 26 citations

Die Behandlung der Hämoblastosen und malignen Tumoren mit Trisaethyleniminobenzochinon^1,2

1960 • 25 citations

CHEMICAL REACTIONS OF MUSTARD GAS AND RELATED COMPOUNDS.¹ II. THE REACTION OF MUSTARD GAS WITH CARBOXYL GROUPS AND WITH THE AMINO GROUPS OF AMINO ACIDS AND PEPTIDES

1946 • 25 citations

Structure-Activity Relationship of Some Diamine Bis-epoxides in Mouse Leukaemia

1959 • 25 citations

728. Cyto-active amino-acids and peptides. Part VIII. N^α-acyl, amide, ester and peptide derivatives of melphalan

1960 • 25 citations

Tumour-inhibiting Action of 1 : 6-Dimethanesulphonyl-D-mannitol

1958 • 25 citations

439. Amines containing 2-halogenoethyl groups

1948 • 24 citations

673. The chemotherapy of schistosomiasis. Part I. Derivatives and analogues of αω-di-(p-aminophenoxy)alkanes

1958 • 23 citations

�ber neue Zuckerderivate mit zytostatischer Wirksamkeit

1955 • 22 citations

Über 2,5‐Bisäthylenimino‐hydrochinon, eine carcinostatisch wirksame Verbindung

1955 • 22 citations

Comparative clinical and biological effects of alkylating agents

1958 • 21 citations

DESIGN OF ALKYLATING AGENTS FOR SELECTIVITY OF ACTION

1958 • 21 citations

THE INFLUENCE OF 1,4‐DIMETHYLSULFONOXY‐1,4‐DIMETHYLBUTANE (CB 2348, DIMETHYL MYLERAN) IN NEOPLASTIC DISEASE

1958 • 20 citations

276. Aryl-2-halogenoalkylamines. Part XVI. The preparation of derivatives of 4-[di-(2-chloroalkyl)amino]azobenzenes

1956 • 20 citations

191. Cyto-active amino-acids and peptides. Part VII. Derivatives of serine and threonine

1959 • 19 citations

117. The preparation of some chloroalkylamino-compounds

1949 • 19 citations

Aryl-2-halogenoalkylamines. Part XIII. Chloroethylamino-derivatives of some phenoxyalkanoic acids and of some substituted α-amino-acids

1955 • 19 citations

The effect of nitrogen mustards on the incorporation of amino acids into protein by Staphylococcus aureus

1957 • 18 citations

604. Aryl-2-halogenoalkylamines. Part XIX. Some NN-di-2-chloroethylamino-phenyl- and -phenylalkyl-hydantions and related amino-acids

1960 • 16 citations

The Effects of a Nitrogen mustard Derivative of Phenylalanine on Experimental Tumours

1956 • 16 citations

Recent advances in chemotherapy of cancer

1959 • 14 citations

201. Some compounds related to the aromatic “nitrogen mustards.”

1950 • 14 citations

Studies on OPSPA. I. The effect of several phosphoramides on transplanted tumors.

1957 • 13 citations

Studies with mustards. II. Paper chromatography and radioautography of reaction mixtures of various compounds with S35-sulfur mustard

1955 • 12 citations

A new series of schistosomicides

1954 • 12 citations

CHEMOTHERAPY OF CANCER BY ETHYLENIMINO QUINONES: ITS FOUNDATIONS AND PROBLEMS

1958 • 11 citations

279. Interaction between carbonyl groups and biologically essential substituents. Part I. The effect of ketones on optically active amino-derivatives

1959 • 11 citations

917. Cyto-active amino-acids and peptides. Part IV. Synthesis of α-[p-di-(2-chloroethyl)amino-benzylidene- and -benzyl-]hippuramides and -hippuramido-acids

1957 • 11 citations

113. The action of ionizing radiations and of radiomimetic substances on deoxyribonucleic acid. Part IV. The products of the action of di-(2-chloroethyl)methylamine

1952 • 10 citations

Dimethanesulphonic acid esters of sugar alcohols

1960 • 10 citations

Comparative Clinical and Biological Effects of Alkylating Agents

1959 • 9 citations

DISCUSSION: PART II

1958 • 9 citations

The Synthesis of m-[Di-(2-chloroethyl)-amino]-DL-phenylalanine

1959 • 9 citations

724. Some NN-di-2-chloroalkyl derivatives of carboxyamides and sulphonamides

1959 • 9 citations

EFFECTS OF P-Di-(2-CHLOROETHYL)-AMINOPHENYLALANINE ON MALIGNANT TUMORS

1960 • 8 citations

Stickstofflost‐Verbindungen, I. Mitteil.: β‐Oxy‐ und β‐Chlor‐äthyl‐Derivate des Nicotin‐ und Isonicotinsäureamids

1954 • 8 citations

CLINICAL TRIALS OF NONANE IN MALIGNANT DISEASE

1958 • 8 citations

Chemotherapy for Cancer by Perfusion in the U.S.A

1960 • 8 citations

N-Bis (^|^beta;-chloroethyl) amino Acids and their Effect upon the Yoshida Sarcoma.

1954 • 8 citations

New Nitrogen Mustards for “Toxagenic” Anti-cancer Agents^1a,b

1956 • 7 citations

Effects of nitrogen mustards on the incorporation of amino acids into the proteins of tissues of tumor-bearing rats. I. Amino acid mustards and HN2.

1960 • 7 citations

Notes- Potential Anticancer Agents. XLIX. Analogs of Chlorambucil. VII. Nitrogen Mustards Derived from Cinnamic Acid.

1961 • 6 citations

N-Bis(β-Chloroethyl)amino Acids and Related Compounds as Tumor-Growth Retarding Agents

1955 • 5 citations

20. Cyto-active amino-acids and peptides. Part VI. Synthesis of N′-α-aminoacyl-NN-di-(2-chloroethyl)-p-phenylenediamines

1959 • 5 citations

Nucleic Acids and Their Role in Future Chemotherapy of Tumours and Virus Diseases

1959 • 5 citations

Studies on Carcinostatic Substances. XXX. Syntheses of Derivatives of Nitrogen Mustard related to Amino Acid.

1960 • 5 citations

Aryl-2-halogenoalkylamines. Part XV. Some cationic and basically substituted aryl compounds

1955 • 5 citations

Further observations on the efficacy of phenylalanine mustards against mouse melanoma.

1961 • 4 citations

Potential Anticancer Agents.¹ XXXVIII. Alkylating Agents Related to Phenylalanine Mustard. II

1960 • 4 citations

341. Cyto-active amino-acids and peptides. Part III. Synthesis of para-substituted phenyl and alkoxymethyl ethers of tyrosine

1957 • 3 citations

579. Synthesis of bis-[p-di-(2-chloroethyl)aminophenoxy]alkanes

1959 • 3 citations

Potential Anticancer Agents.¹ XXXII. Analogs of Chlorambucil. II. Monofunctional Alkylating Agents Derived from 3-(p-Aminophenyl)propionic Acid

1960 • 2 citations

Synthesis of the Racemic and Optically Active Forms of α-Amino-γ-p-di(β-chloroethyl)aminophenylbutyric Acid¹

1958 • 2 citations