Chemical Lesioning: Catecholamine Pathways

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1968 • 1,419 citations

Frontiers in Catecholamine Research

1973 • 1,252 citations

Striatal Dopamine Release after Amphetamine or Nerve Degeneration Revealed by Rotational Behaviour

1971 • 912 citations

The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions.

1962 • 880 citations

Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine

1968 • 862 citations

EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN

1970 • 653 citations

6-Hydroxydopamine and catecholamine neurons

1971 • 637 citations

The pharmacological and anatomical substrates of the amphetamine response in the rat

1975 • 583 citations

Biochemistry of Catecholamines

1971 • 543 citations

Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine

1971 • 535 citations

Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.

1970 • 486 citations

Possible Etiology of Schizophrenia: Progressive Damage to the Noradrenergic Reward System by 6-Hydroxydopamine

1971 • 480 citations

An electron microscopic study of selective, acute degeneration of sympathetic nerve terminals after administration of 6-hydroxydopamine

1968 • 442 citations

Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure

1969 • 421 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes.

1974 • 416 citations

Increase in tyrosine hydroxylase activity after reserpine administration.

1969 • 354 citations

Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine

1973 • 350 citations

Overeating and Obesity from Damage to a Noradrenergic System in the Brain

1973 • 303 citations

Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

1972 • 296 citations

Specificity of 6-hydroxydopamine induced degeneration of central monoamine neurones: An electron and fluorescence microscopic study with special reference to intracerebral injection on the nigro-striatal dopamine system

1973 • 295 citations

Feeding and drinking deficits after 6-hydroxydopamine administration in the rat: similarities to the lateral hypothalamic syndrome

1973 • 292 citations

Turning behavior of mice with unilateral 6-hydroxydopamine lesions in the striatum: Effects of apomorphine, l-DOPA, amantadine, amphetamine and other psychomotor stimulants

1973 • 204 citations

Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine

1972 • 204 citations

Growth and behavioral changes in developing rats treated intracisternally with 6-hydroxydopamine: evidence for involvement of brain dopamine.

1973 • 198 citations

Dynamics of Degeneration and Growth in Neurons

1974 • 196 citations

Sympathetic Nerve Cell Destruction in Newborn Mammals by 6-Hydroxydopamine

1970 • 194 citations

Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.

1974 • 187 citations

Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons

1970 • 185 citations

Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration

1973 • 157 citations

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

1972 • 156 citations

Non-specific histopathological changes induced by the intracerebral injection of 6-hydroxy-dopamine (6-OH-DA)

1972 • 149 citations

Recent Developments on the Ultrastructural Aspect of Adrenergic Nerve Endings in Various Experimental Conditions

1969 • 146 citations

Effects of 6-hydroxydopamine treatments on active avoidance responding: evidence for involvement of brain dopamine.

1973 • 144 citations

Increased irritability: A permanent behavior change induced in the rat by intraventricular administration of 6-hydroxydopamine

1972 • 142 citations

Comparison of tyrosine hydroxylase and dopamine-?-hydroxylase inhibition with the effects of various 6-hydroxydopamine treatments on d-amphetamine induced motor activity

1974 • 135 citations

Facilitated aggression in the rat following 6-hydroxydopamine administration

1972 • 134 citations

ACTION OF 2, 4, 5‐TRIHYDROXYPHENYLETHYLAMINE ON THE STORAGE AND RELEASE OF NORADRENALINE

1965 • 133 citations

Neurochemical mediation of reward: A significant role for dopamine?

1973 • 127 citations

Effect of nerve degeneration by 6-hydroxydopamine on catecholamine-stimulated adenosine 3',5'-monophosphate formation in rat cerebral cortex.

1973 • 124 citations

An ultrastructural and histochemical study of the short‐term effects of 6‐hydroxydopamine on adrenergic nerves in the domestic fowl

1970 • 123 citations

Degeneration and Regrowth of Adrenergic Nerve Fibers in the Rat Peripheral Tissues after 6-Hydroxydopamine

1971 • 115 citations

Attenuation of amphetamine‐induced motor stimulation and stereotypy by 6‐hydroxydopamine in the rat

1973 • 114 citations

Selective action of 6-hydroxydopa on noradrenergic terminals: Mapping of preterminal axons of the brain

1971 • 113 citations

Evidence that punctate intracerebral administration of 6-hydroxydopamine fails to produce selective neuronal degeneration

1974 • 111 citations

Increased cyclic AMP response to norepinephrine in the rat brain following 6-hydroxydopamine

1972 • 99 citations

Effects of 6-hydroxydopamine on putative transmitter substances in the central nervous system

1972 • 97 citations

A comparison of the eating in response to hypothermic and glucoprivic challenges after nigral 6-hydroxydopamine and lateral hypothalamic electrolytic lesions in rats

1973 • 92 citations

Autonomic Neuro-Effector Systems

1937 • 88 citations

Alterations in consummatory behavior following intracisternal injection of 6-hydroxydopamine

1973 • 84 citations

6-Hydroxydopa Depletion of Brain Norepinephrine and the Facilitation of Aggressive Behavior

1972 • 83 citations

Mapping of central noradrenaline pathways with 6-Hydroxy-DOPA

1973 • 83 citations

Chemical sympathectomy in newborn animals

1971 • 81 citations

Central effects of 6‐hydroxydopamine on the body temperature of the rat

1970 • 73 citations

BRAIN DOPAMINE‐β‐HYDROXYLASE: REGIONAL DISTRIBUTION AND EFFECTS OF LESIONS AND 6‐HYDROXY‐DOPAMINE ON ACTIVITY

1972 • 72 citations

Alteration of avoidance and ingestive behavior after destruction of central catecholamine pathways with 6-hydroxydopamine

1974 • 70 citations

Accumulation of adenosine cyclic 3',5'-monophosphate in rat cerebral cortical slices. Stimulatory effect of alpha and beta adrenergic agents after treatment with 6-hydroxydopamine, 2,3,5-trihydroxyphenethylamine, and dihydroxytryptamines.

1973 • 69 citations

Altered ontogenesis of central noradrenergic neurons following neonatal treatment with 6-hydroxydopamine

1972 • 69 citations

Effects of protriptyline on the depletion of catecholamines induced by 6-hydroxydopamine in the brain of the rat

1970 • 66 citations

Chemical and Immunochemical Lesions by Specific Neurotoxic Substances and Antisera

1975 • 66 citations

Effect of L-Dopa on the Locomotor Activity of Rats pretreated with 6-Hydroxydopamine

1971 • 65 citations

6-hydroxydopamine, 6-hydroxydopa and degeneration of adrenergic nerves.

1971 • 64 citations

The role of monoamines in rotation induced or potentiated by amphetamine after nigral, raphé and mesencephalic reticular lesions in the rat brain

1973 • 64 citations

Rat brain L-3,4-dihydroxyphenylalanine and l-5-hydroxytryptophan decarboxylase activities: Differential effect of 6-hydroxydopamine

1973 • 58 citations

Influence of 6-hydroxydopamine on the effect of morphine on the tail-flick latency

1973 • 57 citations

Enhancement by 6-hydroxydopamine of the effects of DOPA upon the motor activity of rats.

1973 • 54 citations

Effect of 6-hydroxydopamine on morphine analgesia

1972 • 52 citations

Shock-induced aggression: Effects of 6-hydroxydopamine and other pharmacological agents

1972 • 52 citations

The roles of monoamine neural systems in the anorexia induced by (+)-amphetamine and related compounds

1975 • 49 citations

NEUROCHEMICAL PROPERTIES OF ADRENERGIC NERVES REGENERATED AFTER 6‐HYDROXYDOPAMINE

1972 • 48 citations

Cardiovascular effects of 6-hydroxydopamine injected into a lateral brain ventricle of the rat

1972 • 48 citations

Hypothermia induced by intraventricular administration of 6-hydroxydopamine in rats

1971 • 47 citations

Development of cortical and nigro-neostriatal dopaminergic systems after destruction of central noradrenergic neurones in foetal or neonatal rats

1975 • 45 citations

Enhanced behavioral depressant effects of reserpine and ?-methyltyrosine after 6-hydroxydopamine treatment

1972 • 45 citations

The effect of 6-hydroxydopamine on morphine tolerance and physical dependence.

1972 • 44 citations

Functional evidence for postsynaptic supersensitivity of central noradrenergic receptors after denervation

1975 • 44 citations

Surgical, Immunological and Chemical Sympathectomy Their Application in the Investigation of the Physiology and Pharmacology of the Sympathetic Nervous System

1972 • 42 citations

Decrease in morphine's analgesic action and increase in its cataleptic action by 6-hydroxydopamine injected bilaterally into caudate and putamen areas; partial restoration by l-DOPA plus decarboxylase inhibition

1973 • 41 citations

Central actions of 6-hydroxydopamine and other phenylethylamine derivatives on body temperature in the rat.

1972 • 40 citations

Biochemical and behavioral alterations following 6-hydroxydopamine administration into brain

1973 • 39 citations

Nonlinear changes in activity and emotional reactivity scores following central noradrenergic lesions in rats

1973 • 39 citations

6-OHDA lesions of the hypothalamus: Interaction of aphagia, food palatability, set-point for weight regulation, and recovery of feeding

1973 • 34 citations

Intracranial injection of drugs: Comparison of diffusion of 6-OHDA and guanethidine

1975 • 33 citations

Effects of intracisternal 6-hydroxydopamine treatment on acquisition and performance of rats in a double T-maze.

1974 • 33 citations

Effects of 6-hydroxydopamine on acetylcholine and GABA metabolism in rat striatum

1973 • 32 citations

Operant behavior and catecholamine-containing neurons: Prolonged increase in lever-pressing after 6-hydroxydopamine

1972 • 30 citations

Effects of intrahypothalamic injection of 6-hydroxydopamine on predatory aggression in rat

1973 • 29 citations

Early Behavioural Effects of Intraventricular Administration of 6-Hydroxydopamine in Rat

1972 • 25 citations

Effects of 6-hydroxydopa

1973 • 24 citations

Effects of depletion of brain catecholamines during the development of morphine dependence on precipitated withdrawal in rats

1975 • 23 citations

Increased fixed-ratio performance and differential d- and l-amphetamine action following norepinephrine depletion by intraventricular 6-hydroxydopamine.

1974 • 22 citations

Aggression in rats treated with dopa and 6-hydroxydopamine

1972 • 22 citations

Behavioral pharmacology of 6-hydroxydopamine

1973 • 16 citations

Effect of central catecholamine depletions by 6-hydroxydopamine on morphine antinociception in rats.

1973 • 16 citations

Relationship of dopamine neural systems to the behavioral alterations produced by 6-hydroxydopamine administration into brain.

1974 • 15 citations

Noradrenaline contents of hypothalamus and adrenal gland increased by postnatal administration of 6-hydroxydopamine.

1971 • 13 citations

Depletion of Brain Amines reverses Blood Pressure Response to Footshock in Rat

1972 • 12 citations

Restoration of morphine analgesia in morphine-tolerant rats after the intraventricular administration of 6-hydroxydopamine

1973 • 11 citations

Cardiovascular changes following DOCA/NaCl or conditioning in 6-hydroxydopamine-treated rats

1974 • 9 citations

The Use of Microknives in Brain Lesion Studies and the Production of Isolated Brain-stem Islands

1972 • 8 citations

The effect of 6-hydroxydopamine on the oestrus cycle and fertility of rats

1974 • 6 citations

ENHANCED SENSITIVITY TO THE NORADRENALINE RECEPTOR STIMULATING AGENT, CLONIDINE, FOLLOWING DEGENERATION OF NORADRENALINE PATHWAYS: STUDIES ON ARTERIAL PRESSURE, HEART RATE, AND RESPIRATION

1974 • 5 citations

A NOTE ON THE ANAESTHETIC CHARACTERISTICS OF METHYL ACETYLENE

1940 • 1 citations