Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

SPLICEOSOMAL snRNAs

1988 • 463 citations

Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding

1986 • 386 citations

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

1984 • 379 citations

The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies.

1984 • 371 citations

Yeast mRNA splicing in vitro.

1985 • 337 citations

Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins

1985 • 307 citations

Structure and function of major and minor small nuclear ribonucleoprotein particles

1989 • 242 citations

Sequence-specific interaction of R17 coat protein with its ribonucleic acid binding site

1983 • 237 citations

Structural organization of ribonucleoproteins containing small nuclear RNAs from HeLa cells

1982 • 184 citations

Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs.

1987 • 171 citations

An essential yeast snRNA with a U5-like domain is required for splicing in vivo

1987 • 168 citations

In vitro assembly of U1 snRNPs.

1987 • 145 citations

Saccharomyces cerevisiae Has a U1-Like Small Nuclear RNA with Unexpected Properties

1987 • 122 citations

Direct, sequence-specific binding of the human U1-70K ribonucleoprotein antigen protein to loop I of U1 small nuclear RNA.

1989 • 89 citations

Alteration of polynucleotide secondary structure by ribosomal protein S1.

1976 • 80 citations

The Mr 70,000 protein of the U1 small nuclear ribonucleoprotein particle binds to the 5' stem-loop of U1 RNA and interacts with Sm domain proteins.

1988 • 75 citations

Direct, Sequence-Specific Binding of the Human U1-70K Ribonucleoprotein Antigen Protein to Loop I of U1 Small Nuclear RNA

1989 • 44 citations

Rapid Inhibition of Processing and Assembly of Small Nuclear Ribonucleoproteins after Infection with Vesicular Stomatitis Virus

1987 • 39 citations

U1 Small Nuclear RNA Genes Are Subject to Dosage Compensation in Mouse Cells

1985 • 33 citations

Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiationin situ

1988 • 28 citations

Isolation of cDNA clones encoding small nuclear ribonucleoparticle-associated proteins with different tissue specificities.

1989 • 28 citations