Is prophylactic cranial irradiation (PCI) needed in patients with extensive-stage small cell lung cancer showing complete response to first-line chemotherapy?

Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission

1999 • 1,607 citations

Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer

2007 • 1,015 citations

Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial

2014 • 994 citations

Prophylactic Cranial Irradiation for Patients With Small-Cell Lung Cancer in Complete Remission

1995 • 513 citations

Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial

2017 • 453 citations

Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: Results of a multicentre randomised trial

1997 • 363 citations

Phase III Trial of Prophylactic Cranial Irradiation Compared With Observation in Patients With Locally Advanced Non–Small-Cell Lung Cancer: Neurocognitive and Quality-of-Life Analysis

2010 • 359 citations

Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis

2001 • 282 citations

Combination chemotherapy for small cell carcinoma of the lung: continuous versus alternating non-cross-resistant combinations.

1982 • 131 citations

Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma.

1983 • 109 citations

Should initial treatment of small cell carcinoma include systemic chemotherapy and brain irradiation?

1973 • 97 citations

Controlled clinical trial of prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission

1998 • 93 citations

Comparative study of prophylactic cranial irradiation in patients with small cell lung cancer achieving a complete response: a long-term follow-up result

1993 • 87 citations

Staging and imaging of small cell lung cancer

2011 • 78 citations

Prevalence of Brain Metastases Immediately before Prophylactic Cranial Irradiation in Limited Disease Small Cell Lung Cancer Patients with Complete Remission to Chemoradiotherapy: A Single Institution Experience

2008 • 61 citations

A case for preplanned thoracic and prophylactic whole brain radiation therapy in limited small-cell lung cancer.

1981 • 59 citations

Treatment Response and Prophylactic Cranial Irradiation Are Prognostic Factors in a Real-life Limited-disease Small-cell Lung Cancer Patient Cohort Comprehensively Staged With Cranial Magnetic Resonance Imaging

2016 • 32 citations

Effect of Accurate Staging Using Positron Emission Tomography on the Outcomes of Prophylactic Cranial Irradiation in Patients With Limited Stage Small-Cell Lung Cancer

2016 • 10 citations