Regulation of Cyclooxygenase-2 by the Activated p38 Mapk Signaling Pathway

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

1995 • 400 citations

Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs

1992 • 313 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

p38 Mitogen-activated Protein Kinase Down-regulates Nitric Oxide and Up-regulates Prostaglandin E2 Biosynthesis Stimulated by Interleukin-1β

1997 • 181 citations

Interactions of PGH Synthase Isozymes‐1 and ‐2 with NSAIDs^a

1994 • 118 citations

Interleukin-1 beta activates c-jun NH2-terminal kinase subgroup of mitogen-activated protein kinases in mesangial cells

1996 • 27 citations