Statistical Aspects of Clinical Trial Design

Statistical Methods for Rates and Proportions

2003 • 17,930 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Repeated Significance Tests on Accumulating Data

1969 • 756 citations

Controversy in Counting and Attributing Events in Clinical Trials

1979 • 414 citations

Allocation of Patients to Treatment in Clinical Trials

1979 • 237 citations

Sample size requirements for evaluating a conservative therapy.

1978 • 228 citations

Allocation of patients to treatment groups in a controlled clinical study

1978 • 190 citations

Sequential medical trials. 2nd edition.

1975 • 153 citations

Statistics and ethics in medical research

1981 • 152 citations

Clinical trial methodology

2015 • 145 citations

In dispraise of the exact test

1978 • 122 citations

D-PENICILLAMINE TREATMENT IMPROVES SURVIVAL IN PRIMARY BILIARY CIRRHOSIS

1981 • 119 citations

The Power Function of the "Exact" Test for Comparing Two Binomial Distributions

1978 • 92 citations

Sample sizes for long-term medical trial with time-dependent dropout and event rates

1980 • 71 citations

Presentation and analysis of the results of clinical trials in cardiovascular disease.

1981 • 40 citations

The Analysis of Data from Clinical Trials

1979 • 39 citations

THE DESIGN OF CLINICAL TRIALS

1979 • 23 citations