Molecular properties and signalling pathways of the histamine H₁ receptor

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

1983 • 1,548 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Histaminergic transmission in the mammalian brain

1991 • 948 citations

The physiological action of β‐iminazolylethylamine

1910 • 867 citations

RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE

1966 • 762 citations

Distribution, properties, and functional characteristics of three classes of histamine receptor.

1990 • 579 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

Molecular pharmacological aspects of histamine receptors

1995 • 353 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Therapeutic potential of histamine H3 receptor agonists and antagonists

1998 • 265 citations

Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

1991 • 230 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Molecular cloning of the human histamine H2 receptor

1991 • 183 citations

Phosphoinositide Phospholipases and G Proteins in Hormone Action

1994 • 151 citations

Molecular basis for the interaction of histamine with the histamine H2 receptor.

1992 • 144 citations

Molecular Cloning of the Human Histamine H1 Receptor Gene

1994 • 136 citations

Genomic Cloning, Heterologous Expression and Pharmacological Characterization of a Human Histamine H1 Receptor

1993 • 131 citations

Histamine stimulates prostacyclin synthesis in cultured human umbilical vein endothelial cells

1980 • 114 citations

Guinea Pig Histamine H₁ Receptor. II. Stable Expression in Chinese Hamster Ovary Cells Reveals the Interaction with Three Major Signal Transduction Pathways

1994 • 110 citations

Site-Directed Mutagenesis of the Histamine H1 Receptor: Roles of Aspartic Acid107, Asparagine198 and Threonine194

1994 • 107 citations

Mechanism of histamine actions in human coronary arteries.

1987 • 102 citations

Cloning and tissue expression of a rat histamine H2-receptor gene

1991 • 99 citations

Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.

1990 • 97 citations

Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery

1984 • 90 citations

Site-Directed Mutagenesis of the Histamine H1-Receptor Reveals a Selective Interaction of Asparagine207 with Subclasses of H1-Receptor Agonists

1994 • 78 citations

Histamine-induced phosphoinositide metabolism in cultured human umbilical vein endothelial cells. Association with thromboxane and prostacyclin release

1987 • 74 citations

Genomic Cloning of the Rat Histamine H1 Receptor

1993 • 69 citations

Histamine‐induced increases in cyclic AMP levels in bovine adrenal medullary cells

1991 • 69 citations

Short‐term desensitization of the histamine H₁ receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways

1992 • 67 citations

Guinea Pig Histamine H₁ Receptor. I. Gene Cloning, Characterization, and Tissue Expression Revealed by In Situ Hybridization

1994 • 67 citations

The Guinea Pig Histamine H2 Receptor: Gene Cloning, Tissue Expression and Chromosomal Localization of Its Human Counterpart

1995 • 62 citations

Histamine‐induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea‐pig ileum

1985 • 61 citations

Synergism between histamine H1- and H2-receptors in the cAMP response in guinea pig brain slices: effects of phorbol esters and calcium.

1988 • 59 citations

Basal and stimulated formation and release of L-arginine-derived nitrogen oxides from cultured endothelial cells.

1990 • 57 citations

Regulation of the human histamine H₁ receptor stably expressed in Chinese hamster ovary cells

1996 • 55 citations

Carbachol and histamine stimulation of guanine-nucleotide-dependent phosphoinositide hydrolysis in rat brain cortical membranes

1989 • 54 citations

Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation

1995 • 54 citations

Stable Expression of Human H₁‐histamine‐receptor cDNA in Chinese Hamster Ovary Cells

1994 • 53 citations

Histamine-induced inositol phospholipid breakdown mirrors H1-receptor density in brain

1983 • 51 citations

Lysine200 Located in the Fifth Transmembrane Domain of the Histamine H1 Receptor Interacts with Histamine but Not with All H1 Agonists

1995 • 49 citations

Pharmacological and Functional Characterisation of the Wild—Type and Site—Directed Mutants of the Human H₁Histamine Receptor Stably Expressed in CHO Cells

1995 • 46 citations

Molecular Cloning of the Guinea-Pig Histamine H1 Receptor Gene

1993 • 42 citations

Cloning, RNA Expression, and Chromosomal Location of a Mouse Histamine H2 Receptor Gene

1996 • 41 citations

Characteristics of the Mouse Genomic Histamine H1 Receptor Gene

1996 • 41 citations

Histaminergic Agonists and Antagonists Recent Developments

1991 • 39 citations

Chromosomal localization of the human histamine H1-receptor gene

1994 • 39 citations

Regulation of histamine H₁ receptor coupling by dexamethasone in human cultured airway smooth muscle

1996 • 38 citations

Effect of histamine on aorta preparations of different species.

1984 • 36 citations

Characterization of histamine H1-receptor binding peptides in guinea pig brain using [125I]iodoazidophenpyramine, an irreversible specific photoaffinity probe.

1988 • 32 citations

Cloning and structure-function of the H2 histamine receptor

1991 • 32 citations

Multiple histamine receptors: properties and functional characteristics

1992 • 32 citations

Histamine H₁‐Receptor in Heart: Unique Electrophoretic Mobility and Autoradiographic Localization

1990 • 29 citations

Cloning of the H1 histamine receptor

1992 • 28 citations

Differential effects of elevated calcium ion concentrations on inositol phospholipid responses in mouse and rat cerebral cortical slices

1990 • 28 citations

The C Terminal Tail of the Histamine H₂ Receptor Contains Positive and Negative Signals Important for Signal Transduction and Receptor Down‐Regulation

1996 • 25 citations

Changes in extracellular calcium within the physiological range influence receptor-mediated inositol phosphate responses in brain and tracheal smooth muscle slices

1989 • 24 citations

Photoaffinity Labeling and Electrophoretic Identification of the H₁‐Receptor: Comparison of Several Brain Regions and Animal Species

1989 • 23 citations

Histamine-stimulated phosphoinositide hydrolysis in developing rat brain.

1987 • 23 citations

The role of calcium in the cyclic AMP response to histamine in rabbit cerebral cortical slices

1987 • 22 citations

Regulation of phosphoinositide hydrolysis induced by histamine and guanine nucleotides in human HeLa carcinoma cells

1990 • 21 citations

Histamine H₁ and Endothelin ET_B Receptors Mediate Phospholipase D Stimulation in Rat Brain Hippocampal Slices

1995 • 21 citations

Regional variation in the characteristics of histamine H₁‐agonist mediated breakdown of inositol phospholipids in guinea‐pig brain

1986 • 19 citations

Biochemical characterization of histamine H1 receptors in bovine adrenal medulla

1991 • 18 citations

Action protectrice des éthers phénoliques au cours de l’intoxication histaminique

2017 • 15 citations

The agonistic binding site at the histamine H2 receptor. I. Theoretical investigations of histamine binding to an oligopeptide mimicking a part of the fifth transmembrane α-helix

1996 • 15 citations

Characterization of histamine-induced contraction in rat isolated aorta

1991 • 13 citations

Temporal changes in the calcium‐dependence of the histamine H₁‐receptor‐stimulation of cyclic AMP accumulation in guinea‐pig cerebral cortex

1989 • 13 citations

Glucocorticoids Enhance Histamine‐Evoked Catecholamine Secretion from Bovine Chromaffin Cells

1995 • 12 citations

Effect of the tachykinin antagonist, [abetd-Pro4, abetd-Trp7,9,10] substance P-(4?11), on tachykinin- and histamine-induced inositol phosphate generation in intestinal smooth muscle

1987 • 10 citations

Functional expression of H1-histaminergic receptors in Xenopus laevis oocytes injected with bovine adrenal medullary mRNA.

1991 • 9 citations

Sequence analysis of the 5′-untranslated region of the human H1 histamine receptor-encoding gene

1996 • 6 citations