Benzodiazepine receptor ligands

Computer-Assisted Drug Design

1979 • 186 citations

Potential Purine Antagonists. VI. Synthesis of 1-Alkyl- and 1-Aryl-4-substituted Pyrazolo[3,4-d]pyrimidines^1,2

1956 • 171 citations

Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

1990 • 119 citations

Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogs of 6-(benzyloxy)-4-(methoxymethyl)-.beta.-carboline-3-carboxylic acid ethyl ester

1990 • 104 citations

Development of a comprehensive pharmacophore model for the benzodiazepine receptor.

1995 • 89 citations

Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors

1994 • 51 citations

Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties

1990 • 45 citations

Molecular yardsticks. Rigid probes to define the spatial dimensions of the benzodiazepine receptor binding site

1992 • 41 citations

The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic

1991 • 36 citations

Reactivity of 1‐(2‐nitrophenyl)‐5‐aminopyrazoles under basic conditions and synthesis of new 3‐, 7‐, and 8‐substituted pyrazolo[5,1‐c][1,2,4]benzotriazine 5‐oxides, as benzodiazepine receptor ligands

1994 • 28 citations

Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site

1994 • 22 citations

Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 3-, 7- and 8-substituted [5,1-c][1,2,4]benzotriazines and 5-oxide derivatives. Part I

1996 • 20 citations

Preparation of 4,6‐diaminopyrazolo[3,4‐d] pyrimidines with variations in substitution at the 1‐ and 3‐positions

1975 • 18 citations

Synthesis and Study of the Anti-inflammatory Properties of Some Pyrazolo[1,5-a]pyrimidine Derivatives

1993 • 14 citations

Pyrazolotriazines from condensation of nitro with amino groups

1971 • 8 citations

New 2,3-substituted 4,7-dihydro-6-(1'H-pyrazol-3'-yl)pyrazolo[1,5-a] pyrimidin-7-ones and related compounds: synthesis and benzodiazepine receptor binding study.

1995 • 7 citations

A behaviorally selective class of thiophene-containing benzodiazepine receptor ligands

1995 • 6 citations

Isosteric replacement of amide by ester function. Synthesis and benzodiazepine receptor affinity of indol-3-ylglyoxylyl ester derivatives.

1997 • 2 citations