Synthesis and Study of the Anti-inflammatory Properties of Some Pyrazolo[1,5-a]pyrimidine Derivatives

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

1962 • 5,670 citations

The aggregation of blood platelets

1963 • 2,125 citations

Intracellular control of human neutrophil secretion. I. C5a-induced stimulus-specific desensitization and the effects of cytochalasin B.

1978 • 283 citations

Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation.

1980 • 221 citations

Prostaglandins and leukotrienes as inflammatory mediators

1987 • 181 citations

Intracellular Control of Human Neutrophil Secretion

1978 • 155 citations

Effects of indomethacin, 5,8,11,14-eicosatetraynoic acid, and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes

1980 • 153 citations

Synthesis and antischistosomal activity of certain pyrazolo[1,5-a]pyrimidines

1981 • 141 citations

3-Halo-5,7-dimethylpyrazolo[1,5-A]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates

1977 • 91 citations

Mode of Action of Anti-Inflammatory Agents Which are Prostaglandin Synthetase Inhibitors

1979 • 87 citations

Inhibition by nonsteroidal anti-inflammatory drugs of superoxide production and granule enzyme release by polymorphonuclear leukocytes stimulated with immune complexes or formyl-methionyl-leucyl-phenylalanine

1987 • 57 citations

Potential antiarthritic agents. 2. Benzoylacetonitriles and .beta.-aminocinnamonitriles

1979 • 47 citations

Synthesis and antitrichomonal activity of certain pyrazolo[1,5-a]pyrimidines

1975 • 42 citations

Adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors. 2. 3-Substituted 5,7-dialkylpyrazolo[1,5-a]pyrimidines

1975 • 38 citations

Chromium Complexes of Azo Dyes Derived from Acylacetonitriles¹

1947 • 36 citations

Adenosine Diphosphate Induced Platelet Aggregation and Release Reaction in Heparinized Platelet Rich Plasma and the Influence of Added Citrate

1977 • 33 citations

2-Phenylpyrazolo[1,5-a]pyrimidin-7-ones. A new class of nonsteroidal antiinflammatory drugs devoid of ulcerogenic activity

1983 • 32 citations

Synthesis and enzymic activity of 6-carbethoxy- and 6-ethoxy-3,7-disubstituted pyrazolo[1,5-a]pyrimidines and related derivatives as adenosine cyclic 3',5'-phosphate phosphodiesterase inhibitors

1982 • 31 citations

Stimulus-response coupling in human platelets. Evidence against a role of paf-acether in the ‘third pathway’

1983 • 31 citations

Leukotrienes

1987 • 31 citations

A Facile Synthesis of 5-Aminopyrazoles by the Reaction of β-Chlorocinnamonitriles with Hydrazine Hydrate

1984 • 28 citations

Role of arachidonic acid metabolism in human platelet activation and irreversible aggregation

1985 • 27 citations

The Preparation of Ethyl α-Carbethoxy-α'-isobutyryl-β-phenylglutarate. Some Observations on the Retrogression of the Michael Reaction

1934 • 16 citations

Autacoid andβ-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils

1984 • 14 citations

5‐Lipoxygenase, leukotrienes, and regulation of inflammatory responses

1987 • 13 citations

Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats.

1989 • 13 citations

Pharmacological activity of FPP028 (2-phenylpirazolo-4-ethyl-4,7-dihydro [1,5a] pirimidin-7-one) a new non-steroid anti-inflammatory agent

1986 • 3 citations

FPP-028

1987 • 1 citations