Diagnosis and Monitoring of Chronic Myeloid Leukemia by Qualitative and Quantitative RT-PCR

Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

2000 • 3,871 citations

Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems

2002 • 2,534 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Frequency of Major Molecular Responses to Imatinib or Interferon Alfa plus Cytarabine in Newly Diagnosed Chronic Myeloid Leukemia

2003 • 1,253 citations

A multi-rule Shewhart chart for quality control in clinical chemistry.

1981 • 814 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects

2003 • 561 citations

Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction) [see comments]

1996 • 390 citations

Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation

1993 • 388 citations

Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR

1999 • 285 citations

Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real‐time quantitative RT‐PCR

1998 • 247 citations

Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics

1999 • 245 citations

Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation

1996 • 199 citations

Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon α

2002 • 179 citations

Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: correlations with acute graft‐versus‐host disease and relapse

1993 • 170 citations

Early detection of BCR-ABL transcripts by quantitative reverse transcriptase–polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia

2001 • 162 citations

Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase

2003 • 161 citations

New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia

1990 • 154 citations

The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia

2003 • 152 citations

The significance of bcr-abl molecular detection in chronic myeloid leukemia patients “late,” 18 months or more after transplantation

2001 • 146 citations

2 BCR-ABL gene variants

1997 • 145 citations

Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon α/ara-C

2003 • 129 citations

Molecular monitoring of response to imatinib (Glivec®) in CML patients pretreated with interferon alpha. Low levels of residual disease are associated with continuous remission

2003 • 98 citations

Molecular monitoring of chronic myeloid leukemia

2003 • 90 citations

Kinetics of BCR‐ABL fusion transcript levels in chronic myeloid leukemia patients treated with STI571 measured by quantitative real‐time polymerase chain reaction

2001 • 62 citations

A novel BCR–ABL transcript (e8a2) with the insertion of an inverted sequence of ABL intron 1b in a patient with Philadelphia‐positive chronic myeloid leukaemia

2000 • 43 citations

A novel acute lymphoid leukaemia type BCR/ABL transcript in chronic myelogenous leukaemia

1997 • 39 citations

Two patients with novel BCR/ABL fusion transcripts (e8/a2 and e13/a2) resulting from translocation breakpoints within BCR exons

1999 • 28 citations

A novel BCR-ABL rearrangement in a Philadelphia chromosome-positive chronic myelogenous leukaemia variant with thrombocythaemia

1998 • 18 citations