Degradation of Pyrimidines — Enzymes, Localization and Role in Metabolism

Pyrimidine metabolism in microorganisms

1970 • 446 citations

The Molecular Biology of Cancer

1974 • 298 citations

Degradation of purines and pyrimidines by microorganisms.

1976 • 270 citations

Fluorinated Pyrimidines

1965 • 252 citations

Purines and Pyrimidines

1961 • 250 citations

Thymidine Kinase: Evidence for its Absence from Neurospora crassa and Some Other Micro-organisms, and the Relevance of This to the Specific Labelling of Deoxyribonucleic Acid

1968 • 203 citations

METABOLISM OF THYMINE (METHYL-C14 OR −2-C14) BY RAT LIVER IN VITRO

1956 • 202 citations

Pyrimidine metabolism in microorganisms.

1970 • 198 citations

Conditions for Purine Synthesis: Did Prebiotic Synthesis Occur at Low Temperatures?

1966 • 195 citations

METABOLISM OF CYTOSINE, THYMINE, URACIL, AND BARBITURIC ACID BY BACTERIAL ENZYMES

1952 • 133 citations

THE PURIFICATION AND PROPERTIES OF HYDROPYRIMIDINE HYDRASE

1957 • 129 citations

ENZYMATIC SYNTHESIS AND BREAKDOWN OF A PYRIMIDINE, OROTIC ACID

1954 • 119 citations

Enzymatic Studies on the Metabolism of β-Alanine

1961 • 119 citations

Control of gene expression in carbohydrate, pyrimidine and DNA metabolism

1971 • 93 citations

Regulation of purine biosynthesis

1972 • 86 citations

A Review: Biological and Clinical Aspects of Pyrimidine Metabolism

1974 • 85 citations

THE CATABOLISM OF C14-LABELED URACIL, DIHYDROURACIL, AND β-UREIDOPROPIONIC ACID IN RAT LIVER SLICES

1957 • 82 citations

Nucleotide Metabolism

1973 • 81 citations

Incorporation of pyrimidine deoxyribonucleosides into liver lipids and other components

1971 • 78 citations

Incorporation of thymidine into chloroplasts of Spirogyra

1959 • 76 citations

Kinetic study of thymine 7-hydroxylase from Neurospora crassa

1975 • 74 citations

Dihydrouracil dehydrogenase activity in normal, differentiating and regnerating liver and in hepatomas.

1971 • 74 citations

Behavior of opposing pathways of thymidine utilization in differentiating, regenerating, and neoplastic liver.

1971 • 70 citations

Carbohydrate metabolism in cancer cells and the molecular correlation concept

1968 • 69 citations

PANTOTHENATE STUDIES

1952 • 63 citations

THE CATABOLISM OF URACIL IN VIVO AND IN VITRO

1954 • 61 citations

Antimetabolites of Nucleic Acid Metabolism

1951 • 61 citations

The Heterogeneous Distribution of Mitochondrial Enzymes in Normal Rat Liver^*

1967 • 60 citations

Key enzymes of IMP metabolism: Transformation- and proliferation-linked alterations in gene expression

1976 • 60 citations

Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase

1973 • 59 citations

Propionic Acid Metabolism

1960 • 58 citations

ENZYMATIC DECARBAMYLATION OF CARBAMYL β-ALANINE AND CARBAMYL β-AMINOISOBUTYRIC ACID

1958 • 56 citations

THE CATABOLISM OF C14-LABELED β-ALANINE IN THE INTACT RAT

1955 • 53 citations

Relative Retention of H3 and C14 Labels of Nucleosides Incorporated into Nucleic Acids of Neurospora

1962 • 53 citations

The relationship of thymidine metabolism to the use of fractional incorporation as a measure of DNA synthesis and tissue proliferation

1978 • 52 citations

Changes in activities of the de novo and salvage pathways of pyrimidine nucleotide biosynthesis during germination of black gram (Phaseolus mungo) seeds

1977 • 52 citations

Problems in the use of [Me-3H]thymidine for the measurement of DNA synthesis

1973 • 51 citations

The purification and properties of hydropyrimidine dehydrogenase

1957 • 51 citations

Fat metabolism in higher plants

1962 • 50 citations

Properties and Assay of Dihydrouracil Dehydrogenase of Rat Liver

1960 • 49 citations

Formation of vicine and convicine by Vicia faba

1972 • 48 citations

REDUCTIVE DEGRADATION OF PYRIMIDINES

1957 • 48 citations

Cofactor requirements of thymine 7-hydroxylase

1967 • 47 citations

Synthesis of uracil and thymine under simulated prebiotic conditions

1977 • 47 citations

Operation of pleiotropic control in hormonal regulation and in neoplasia

1974 • 46 citations

REDUCTIVE DEGRADATION OF PYRIMIDINES II. Clostridium uracilicum

1957 • 46 citations

Isolation and characterization of 1-alanyl-uracil (willardiine) and 3-alanyl-uracil (ISO-willardiine) from Pisumsativum

1968 • 46 citations

Possible pathway for prebiotic uracil synthesis by photodehydrogenation

1976 • 44 citations

The utilization of purines and pyrimidines by yeasts

1968 • 43 citations

The Relation between Uracil-catabolizing Enzymes and Rate of Rat Liver Regeneration

1962 • 43 citations

METABOLISM OF PYRIMIDINES BY A SOIL BACTERIUM

1952 • 42 citations

Studies of a Mutation Affecting Pyrimidine Degradation in Inbred Mice

1970 • 42 citations

α-KETOGLUTARATE-COUPLED DIOXYGENASES

1974 • 42 citations

Mouse Kidney Cytidine Deaminase

1968 • 42 citations

Mutants Affecting Thymidine Metabolism in Neurospora crassa

1969 • 41 citations

Comparison of incorporation and metabolism of RNA pyrimidine nucleotide precursors in leaf tissues.

1965 • 40 citations

Isolation of a new amino acid from Lathyrus tingitanus

1961 • 40 citations

Molecular Correlation Concept

1974 • 39 citations

Ordered and specific pattern of gene expression in neoplasia

1973 • 38 citations

18O Studies of the 2-Ketoglutarate-dependent Sequential Oxygenation of Thymine to 5-Carboxyuracil

1971 • 38 citations

The Enzymatic Conversion of Uracil 5-Carboxylic Acid to Uracil and Carbon Dioxide

1970 • 37 citations

The effects of various metabolites and anti-metabolites on the regeneration of fragments of Acetabularia mediterranea

1958 • 37 citations

Enzymic interconversion of hydrouracil and β-ureidopropionic acid

1955 • 35 citations

Catabolism of Pyrimidines in Rape Seedlings

1965 • 35 citations

7-Hydroxylation of thymine in a neurospora strain coupled to oxidative decarboxylation of 2-ketoglutarate

1970 • 34 citations

A New Amino-acid, γ-Hydroxyhomoarginine, in Lathyrus

1963 • 34 citations

The cell-free conversion of a deoxyribonucleoside to a ribonucleoside without detachment of the deoxyribose

1968 • 34 citations

STUDIES ON THE ASPARTIC ACID DECARBOXYLASE OF RHIZOBIUM TRIFOLII

1949 • 33 citations

Thymidine 2′-Hydroxylation in Neurospora crassa

1972 • 33 citations

The formation of 5-formyluracil by cell-free preparations from Neurospora crassa

1968 • 32 citations

STUDIES ON OXYGENASES

1957 • 32 citations

Conversion of Thymine to 5-Hydroxymethyluracil in a Cell-free System

1964 • 31 citations

Purines and Pyrimidines

1970 • 30 citations

Regulation of Purine and Pyrimidine Metabolism

1971 • 30 citations

Formation of β-Alanine by Pine Tissues Supplied With Intermediates in Uracil & Orotic Acid Metabolism

1962 • 30 citations

The Enzymatic Conversion of 5-Formyluracil to Uracil 5-Carboxylic Acid

1970 • 29 citations

Pyrimidine metabolism in germinating seedlings

1961 • 29 citations

A possible prebiotic synthesis of thymine: Uracil-formaldehyde-formic acid reaction

1977 • 29 citations

Biosynthesis of the pyrimidinyl amino acid lathyrine by Lathyrus tingitanus L.

1977 • 28 citations

Studies on enzymes involved in nucleic acid metabolism in foetal, young and regenerating rat liver

1963 • 28 citations

Metabolism of pyrimidine deoxyribonucleosides in Neurospora crassa

1975 • 28 citations

The metabolism of pyrimidines by proteolytic clostridia

1975 • 27 citations

Studies pertaining to the purification and properties of thymine 7-hydroxylase

1971 • 27 citations

Structure of a pyrimidine amino acid from pea seedlings

1969 • 27 citations

Dihydrouracil Dehydrogenase of Rat Liver

1971 • 26 citations

Degradation of pyrimidines in Euglena gracilis I. Studies iwth intact cells

1975 • 25 citations

Stoichiometry of the pyrimidine deoxyribonucleoside 2'-hydroxylase reaction and of the conversions of 5-hydroxymethyluracil to 5-formyluracil and of the latter to uracil-5-carboxylic acid

1972 • 24 citations

Pyrimidine Metabolism in Cotyledons of Germinating Alaska Peas

1971 • 24 citations

Beta-aminoisobutyric acid, a new probe for the metabolism of DNA and RNA in normal and tumorous tissue.

1974 • 24 citations

Chemical evolution XXIX. Pyrimidines from hydrogen cyanide

1977 • 24 citations

Uptake and incorporation of pyrimidines in Euglena gracilis

1976 • 24 citations

DIHYDROURACIL AS A GROWTH FACTOR FOR MUTANT STRAINS OFESCHERICHIA COLI

1957 • 23 citations

URACIL OXIDASE AND THE ISOLATION OF BARBITURIC ACID FROM URACIL OXIDATION

1952 • 23 citations

Synthetic pyrimidines as inhibitors of uracil and thymine degradation by rat-liver supernatant

1964 • 22 citations

An autoradiographic study of the macronuclear changes occurring in Paramecium aurelia during autogamy

1962 • 21 citations

Uptake of Uracil by Synchronous Chlorella fusca

1972 • 19 citations

Incorporation of Dihydrouridine Monophosphate and Uridine Monophosphate into Liver and Brain Ribonucleic Acid

1964 • 19 citations

Uracil metabolism inNeurospora crassa

1957 • 18 citations

Thymine and Uracil Catabolism in Escherichia coli

1972 • 18 citations

Purification and Properties of Dihydrouracil Dehydrogenase from Pig Liver

1970 • 18 citations

Verwertung von Pyrimidinderivaten durch Hydrogenomonas facilis

1969 • 17 citations

Regulation of thymidine metabolism in Neurospora crassa

1976 • 17 citations

Organization of purine degradation in the liver of a teleost (carp; cyprinus carpio L.). A study of its subcellular distribution

1977 • 16 citations

Contribution of hydrouracil and its derivatives to pyrimidine biosynthesis I. Scope of contribution and some properties of the incorporating system

1959 • 16 citations

The Chemistry and Metabolism of the Nucleic Acids, Purines, and Pyrimidines

1933 • 15 citations

[Utilization of cytosine and uracil by Hydrogenomonas facilis and Hydrogenomonas H16].

1968 • 15 citations

Degradation of pyrimidines in Euglena gracilis II. Inhibition of degradation by structural analogues and their own degradation

1977 • 15 citations

Degradation of pyrimidines in Euglena gracills III. Ratio of uracil to thymine degradation

1977 • 14 citations

Some pyrimidine derivatives as new types of plant stimulants

1960 • 14 citations

Verwertung von Pyrimidinderivaten durch Hydrogenomonas facilis

1969 • 14 citations

Degradation of uracil by synchronous cultures of Chlorella fusca

1972 • 14 citations

Pyrimidine reducing enzymes of rat liver

1976 • 14 citations

Verwertung von Cytosin und Uracil durch Hydrogenomonas facilis und Hydrogenomonas H 16

1968 • 14 citations

Pyrimidine Metabolism in Acinetobacter calcoaceticus

1973 • 13 citations

Non-specific incorporation of H3-thymidine into the chloroplasts of Spirogyra grevilleana

1966 • 13 citations

Simultaneous inhibition of thymidine degradation and stimulation of incorporation into DNA by 5-fluorodeoxyuridine

1975 • 13 citations

Control by Ammonium of Intercompartmental Guanine Transport in Chlorella

1975 • 13 citations

Uptake of guanine by synchronizedChlorella fusca

1974 • 13 citations

panD, a new chromosomal locus of Salmonella typhimurium for the biosynthesis of β-alanine

1975 • 13 citations

Biochemical strategy of the cancer cell: Malignant transformationlinked enzymatic imbalance

1975 • 13 citations

Substrate specificity of the hydroxylase reaction in which thymidine is converted to thymine ribonucleoside

1972 • 12 citations

Studies of orotidine 5′-phosphate decarboxylase in Neurospora crassa

1967 • 11 citations

Delayed synthesis of uracil-degrading enzymes in regenerating rat liver

1964 • 11 citations

The effect of uracil analogues on the metabolism of pyrimidines in cucumber seedlings

1960 • 10 citations

5,6-Dihydrouracil: Its occurrence and metabolism in rat brain

1970 • 9 citations

Relationship between urinary beta-aminoisobutyric acid and transfer RNA turnover in cancer patients.

1974 • 9 citations

Urea formation from pyrimidines in fruit-bodies of higher basidiomycetes

1964 • 7 citations

Le Catabolisme Réductif de L'uracileChez Torulopsis Utilis

1964 • 7 citations

Enzymatic Preparation of Labeled Intermediates of Thymine Catabolism: Dihydrothymine and β-Ureidoisobutyric Acid

1968 • 6 citations

[14C] carbamoyl-beta-alanine as precursor of pyrimidines in higher plants.

1963 • 6 citations

The growth stimulating effect of 5-bromouracil and uracil on chlorococcal algae

1974 • 5 citations

[Utilization of pyrimidine derivatives by Hydrogenomonas facilis. I. Intermediates and enzymes of cytosine degradation].

1969 • 5 citations

The stimulatory effect of uracil and 5-bromouracil on the seed set inPapaver somniferum L.

1972 • 3 citations

The Chemistry and Metabolism of the Nucleic Acids, Purines, and Pyrimidines

1935 • 3 citations

Aspekte des Thyminstoffwechsels bei Athiorhodaceen

1972 • 2 citations

Aspekte des Thyminstoffwechsels bei Athiorhodaceen

1972 • 2 citations

VIber neue Arbeiten zur Biosynthese N-heterocyclischer Verbindungen.VII.Bildung und Abbau von Verbindungen mit pyrimidinringsystem.

1967 • 1 citations

Microbiological decarboxylation of orotic acid to uracil

1965 • 1 citations