A Review: Biological and Clinical Aspects of Pyrimidine Metabolism

Pyrimidine metabolism in microorganisms

1970 • 446 citations

The Biological Significance of Purine Salvage

1971 • 406 citations

Carbohydrates in Cell Surfaces

1970 • 358 citations

Studies of the enzymatic deamination of cytosine arabinoside—I

1965 • 296 citations

Nucleic acid metabolism in regenerating rat liver. VI. Soluble enzymes which convert thymidine to thymidine phosphates and DNA.

1959 • 286 citations

Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis

1973 • 248 citations

Induced cell proliferation: The effect of isoproterenol

1965 • 207 citations

Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of the six biosynthetic enzymes

1973 • 205 citations

Stimulation of DNA synthesis by isoproterenol in the salivary gland

1965 • 201 citations

Pyrimidine metabolism in microorganisms.

1970 • 198 citations

Citrulline synthesis in rat tissues

1961 • 189 citations

STUDIES IN THE METABOLISM OF PURINES AND PYRIMIDINES BY MEANS OF ISOTOPIC NITROGEN

1944 • 188 citations

Phospholipid Metabolism

1972 • 184 citations

Metabolism of Ribonucleic Acid after Partial Hepatectomy

1963 • 181 citations

Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. I. Kinetics of incorporation of nucleosides into nucleotide pools and pool sizes during growth cycle

1971 • 181 citations

PYRIMIDINE METABOLISM

1956 • 178 citations

Correlation of Brain Metabolism and Function by the Use of a Brain Perfusion Method In Situ

1958 • 168 citations

Hyperammonemia accompanying parenteral nutrition in newborn infants

1972 • 164 citations

Changes in the Metabolism of Ribonucleic Acid Preceding the Synthesis of Deoxyribonucleic Acid in Mammalian Cells Cultured from the Animal

1963 • 161 citations

Allopurinol: Alteration in Pyrimidine Metabolism in Man

1970 • 151 citations

CYTIDINE AND URIDINE REQUIREMENT OF THE BRAIN*†

1956 • 146 citations

Fatty Liver Induced by Orotic Acid Feeding

1955 • 137 citations

The Synthesis of Acidic Nuclear Proteins in the Prereplicative Phase of the Isoproterenol-stimulated Salivary Gland

1970 • 135 citations

Uridine Kinase from Ehrlich Ascites Tumor: Purification and Properties

1960 • 129 citations

Control of Pyrimidine Biosynthesis in Mammalian Tissues

1969 • 129 citations

THE PURIFICATION AND PROPERTIES OF HYDROPYRIMIDINE HYDRASE

1957 • 129 citations

Soluble Uridine Diphosphate d-Galactose:d-Glucose β-4-d-Galactosyltransferase from Bovine Milk

1966 • 124 citations

A Glutamine-dependent Enzyme for the Synthesis of Carbamyl Phosphate for Pyrimidine Biosynthesis in Fetal Rat Liver

1967 • 119 citations

Thymidine kinase in rat liver during development

1968 • 117 citations

Initial Steps in Pyrimidine Synthesis in Ehrlich Ascites Carcinoma in Vitro

1967 • 110 citations

Intestinal Enzymes: Indicators of Proliferation and Differentiation in the Jejunum

1970 • 109 citations

Enzymes of uracil metabolism in tissues with different growth characteristics

1960 • 108 citations

STUDIES ON THE BIOSYNTHESIS OF CARBAMYLASPARTIC ACID

1956 • 105 citations

Studies on the coordinate activity and lability of orotidylate phosphoribosyltransferase and decarboxylase in human erythrocytes, and the effects of allopurinol administration

1971 • 104 citations

Fatty Livers Induced by Orotic Acid

1963 • 102 citations

Feedback onhibition of uridine kinase by cytidine triphosphate and uridine triphosphate

1964 • 101 citations

7 Aspartate Transcarbamylases

1973 • 100 citations

The morphology of the polysaccharide coat of mammalian cells

1972 • 100 citations

Metabolite Distribution in Cells

1972 • 98 citations

Pyrimidine Nucleotide Synthesis: Regulatory Control during Transformation of Lymphocytes in vitro

1967 • 96 citations

Familial Lipoprotein Deficiency

1978 • 95 citations

Inhibition of stimulation of DNA synthesis by isoproterenol in submandibular glands of mice

1966 • 95 citations

Control of Pyrimidine Biosynthesis in Mammalian Tissues

1972 • 93 citations

Control of gene expression in carbohydrate, pyrimidine and DNA metabolism

1971 • 93 citations

Carbamyl phosphate synthetase of the hematopoietic mouse spleen and the control of pyrimidine biosynthesis

1967 • 93 citations

Regulation of pyrimidine and arginine biosynthesis in mammals

1971 • 92 citations

HEREDITARY OROTIC ACIDURIA

1970 • 91 citations

Stimulation of DNA synthesis by isoproterenol and its inhibition by actinomycin D

1967 • 90 citations

Purification and Kinetic Properties of Brain Orotidine 5′-Phosphate Decarboxylase

1968 • 87 citations

3-Ribosylpurines

1964 • 87 citations

Inhibition of thymidine kinase activity in liver and hepatomas by TTP and d-CTP

1964 • 86 citations

Metabolic and Genetic Studies of a Family with Ornithine Transcarbamylase Deficiency

1974 • 86 citations

Early Changes in Pyrimidine Biosynthesis after Partial Hepatectomy

1965 • 84 citations

Orotic Aciduria and Arginine Deficiency

1973 • 84 citations

Repression and Derepression of Purine Biosynthesis in Mammalian Hepatoma Cells in Culture

1972 • 83 citations

Effects of orotic acid on purine and lipoprotein metabolism in man

1970 • 82 citations

Copurification of carbamoyl phosphate synthetase and aspartate transcarbamoylase from mouse spleen

1971 • 80 citations

Incorporation of pyrimidine deoxyribonucleosides into liver lipids and other components

1971 • 78 citations

BIOCHEMICAL AND NUTRITIONAL STUDIES ON THE INDUCTION OF FATTY LIVERS BY DIETARY OROTIC ACID

1960 • 76 citations

Dihydrouracil dehydrogenase activity in normal, differentiating and regnerating liver and in hepatomas.

1971 • 74 citations

A SYNTHESIS OF ISOTOPIC CYTOSINE AND A STUDY OF ITS METABOLISM IN THE RAT

1949 • 73 citations

Physiological Thymidine Reutilization in Rat Bone Marrow.

1966 • 72 citations

Purification and Properties of Orotic Acid-decarboxylating Enzymes from Calf Thymus

1964 • 71 citations

Purification and Properties of Orotidylate Decarboxylases from Yeast and Rat Liver

1961 • 70 citations

Behavior of opposing pathways of thymidine utilization in differentiating, regenerating, and neoplastic liver.

1971 • 70 citations

Studies on the Metabolism of 5-Iodo-2'-deoxycytidine in Vitro

1963 • 69 citations

THE URICOSURIA AND OROTIC ACIDURIA INDUCED BY 6-AZAURIDINE*

1961 • 68 citations

Regulation of activity of carbamoyl phosphate synthetase from mouse spleen

1971 • 68 citations

Initial steps in pyrimidine synthesis in ehrlich ascites carcinoma

1971 • 67 citations

Nucleotides and Nucleic Acids

1970 • 66 citations

Enzymes of thymidine triphosphate synthesis in selected Morris hepatomas.

1969 • 66 citations

Hereditary Orotic Aciduria and Megaloblastic Anaemia: A Second Case, with Response to Uridine

1965 • 64 citations

Initial Steps in Pyrimidine Synthesis in Ehrlich Ascites Carcinoma in Vitro

1965 • 64 citations

Glutamine-dependent Carbamyl Phosphate Synthetase

1970 • 60 citations

Protein Synthesis in the Early Prereplicative Phase of Isoproterenol-stimulated Synthesis of Deoxyribonucleic Acid

1969 • 59 citations

The control of glycogen synthesis in the liver

1970 • 59 citations

Orotic aciduria

1969 • 56 citations

Carbamyl phosphate-aspartate transcarbamylase activity in tumors.

1959 • 56 citations

ENZYMATIC DECARBAMYLATION OF CARBAMYL β-ALANINE AND CARBAMYL β-AMINOISOBUTYRIC ACID

1958 • 56 citations

Regulation of Uridylic Acid Biosynthesis in Eukaryotic Cells

1972 • 56 citations

Biochemical Aspects of Reticulocyte Maturation

1962 • 56 citations

Control of Pyrimidine Biosynthesis in Human Lymphocytes

1971 • 55 citations

Multiple forms of uridine kinase in normal and neoplastic rat liver

1971 • 55 citations

On the availability of intramitochondrial carbamoylphosphate for the extramitochondrial biosynthesis of pyrimidines

1969 • 54 citations

Activation by 5-phosphoribosyl 1-pyrophosphate of glutamine-dependent carbamyl phosphate synthetase from mouse spleen

1972 • 54 citations

Feedback Control in Ehrlich Ascites Cells

1961 • 54 citations

Some pyrimidines of biological and medicinal interest. 3.

1971 • 53 citations

Increased DNA polymerase activity in a series of rat hepatomas.

1969 • 52 citations

OROTIC ACID IN MILK

1953 • 52 citations

Inhibition of Orotidylic Acid Decarboxylase by Uridine 5′-Phosphate

1961 • 52 citations

Cell Damage by Trapping of Biosynthetic Intermediates. The Role of Uracil Nucleotides in Experimental Hepatitis

1971 • 52 citations

STUDIES ON THE ORIGIN OF PYRIMIDINES FOR BIOSYNTHESIS OF NEURAL RNA IN THE RAT

1971 • 52 citations

The purification and properties of hydropyrimidine dehydrogenase

1957 • 51 citations

Stimulation of RNA synthesis in the salivary gland by isoproterenol

1966 • 50 citations

Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis.

1971 • 50 citations

Control of Pyrimidine Biosynthesis in Mammalian Tissues

1972 • 49 citations

Induction of DNA synthesis by a purified chemical compound.

1970 • 49 citations

Nucleic acid metabolism in proliferating and differentiating colonic cells of man and in neoplastic lesions of the colon.

1971 • 47 citations

Comparative biochemistry of hepatomas. VI. Thymidine incorporation into DNA as a measure of hepatoma growth rate.

1966 • 46 citations

Studies of the incorporation of [5−3H]uridine during activation and transformation of lymphocytes induced by phytohaemagglutinin. Dependence of the incorporation rate on uridine concentration at certain critical concentrations

1968 • 45 citations

Pyrimidine Synthesis Pathway Enzymes and Orotic Acid in Bovine Mammary Tissue

1971 • 45 citations

The comparative enzymology and cell origin of rat hepatomas. IV. Pyrimidine metabolism in minimal-deviation tumors.

1963 • 44 citations

Effect of Uridine on de Novo Pyrimidine Biosynthesis in Rat Hepatoma Cells in Culture

1974 • 43 citations

Application of the isotope-dilution principle to the analysis of factors affecting the incorporation of [3H]uridine and [3H]cytidine into cultured lymphocytes. Evaluation of pools in serum and culture media

1971 • 43 citations

Mouse Kidney Cytidine Deaminase

1968 • 42 citations

The short gut syndrome

1971 • 41 citations

Studies on resistance against 5-fluorouracil IV. Evidence for an altered uridine kinase in resistant cells

1963 • 40 citations

Formation of Orotidine 5′-Phosphate by Enzymes from Rat Liver

1960 • 39 citations

Metabolic aspects of ‘orotic acid fatty liver’. Nucleotide control mechanisms of lipid metabolism

1964 • 39 citations

RNA TURNOVER IN NORMAL RAT BONE MARROW*

1964 • 36 citations

Activity and distribution of the enzymes of uridylate synthesis from orotate in animal tissues

1972 • 34 citations

Orotic Acid in Food Milk Powders

1969 • 33 citations

Enzymes in pyrimidine biosynthesis

1971 • 32 citations

An attempt to find pyrimidine inhibitors of a mammalian aspartate carbamoyltransferase

1964 • 31 citations

Congenital disorders of the urea cycle and ammonia detoxication.

1971 • 30 citations

Enzyme and Template Stability As Regulatory Mechanisms in Differentiating Intestinal Epithelial Cells

1970 • 29 citations

Stimulation of Hepatic Purine Biosynthesis by Orotic Acid

1965 • 29 citations

Control of pyrimidine biosynthesis in mammalian tissues. II. Glutamine-utilizing carbamoyl phosphate synthetase of various experimental tumors: distribution, purification and characterization

1970 • 28 citations

Species specificity in orotic acid induced fatty liver.

1968 • 28 citations

Relationship of Pyrimidine Biosynthetic Enzymes to Cellular Proliferation in Rat Intestine During Development

1970 • 27 citations

The Nature of pH Discriminant Differences in the Behavior of Various Phosphoanhydrides, Mixed Phosphate Anhydrides, and Phosphate Esters as Substrates and Inhibitors with Microsomal Glucose 6-Phosphatase

1971 • 25 citations

Pyrimidine Biosynthesis during Development of Rat Cerebellum

1972 • 24 citations

Biosynthesis of Pyrimidines by Various Organs of the Chick During Embryogenesis

1970 • 24 citations

3 Some Pyrimidines of Biological and Medicinal Interest—Part III

1971 • 23 citations

Cytoplasmic ribonucleic acid synthesis in the prereplicative phase of isoproterenol-induced cell proliferation

1970 • 23 citations

Operation of orotic acid pathway as the major source of pyrimidines in the hematopoietic mouse spleen

1966 • 22 citations

Comparative Activties of Aspartate Transcarbamylase in Various Tissues of the Rat.

1967 • 22 citations

Enzyme patterns in a group of transplantable mouse hepatomas of different growth rates.

1971 • 22 citations

Rates of formation of blood-borne uridine and cytidine in dogs

1971 • 21 citations

Fetomaternal production and transfer of progesterone and uridine in sheep

1972 • 19 citations

Liver acid-soluble nucleotides in orotic acid-fed rats

1962 • 18 citations

Glycolipid Synthesis in the Early Prereplicative Phase of Isoproterenol-stimulated Salivary Glands of Mice

1971 • 17 citations

Transplacental passage of nucleotides, nucleosides, and bases

1968 • 17 citations

Biosynthesis of Pyrimidine Nucleotides in Mouse Salivary Glands Stimulated with Isoproterenol

1973 • 16 citations

Activities of enzymes of pyrimidine nucleotide synthesis in slowly growing kidney tumors.

1969 • 16 citations

Hypocholesterolaemia and Orotic Aciduria During Treatment with 6-Azauridine

1965 • 15 citations

Prevention of Orotic Acid-Induced Fatty Liver with Allopurinol

1971 • 14 citations

Deoxycytidylate deaminase and related enzymes of thymidine triphosphate metabolism in hepatomas and precancerous rat liver

1969 • 13 citations

Placental transfer of orotic acid, uridine, and UMP

1968 • 13 citations

Small gut mucosal activites of pyrimidine precursor enzymes in celiac disease.

1969 • 13 citations

The protoplasmic patterns of tissues and tumors.

1972 • 12 citations

Studies on Orotic Acid Fatty Liver in Rats: Factors influencing the induction of fatty liver

1969 • 12 citations

Pool size and specific activity of UTP in isoproterenol-stimulated salivary glands

1969 • 12 citations

Metabolism of Ingested Ammonium-15N by Premature Infants

1970 • 11 citations

Small gut mucosal activities of pyrimidine precursor enzymes in celiac disease

1969 • 11 citations

A study of the possible role of feedback inhibition of aspartate transcarbamylase in regulation of pyrimidine synthesis in human leukocytes.

1967 • 10 citations

Foetal and Maternal RNA labelled with 3H-Cytidine

1972 • 9 citations

Metabolism of Isotopically Labeled Uracil and Uridine in Man

1963 • 8 citations

Slutamine-dependent carbamyl phosphate synthetase in placenta and fetal structures of the rat

1971 • 7 citations

The Chemical Components of Milk which Prevent the Fatty Liver Induced by Orotic Acid

1964 • 6 citations

Purine and pyrimidine biosynthesis. Allopurinol and inborn errors.

1971 • 2 citations

Studies on resistance against 5-fluorouracil IV. Evidence for an altered uridine kinase in resistant cells

1963 • 1 citations

Control of pyrimidine biosynthesis in mammalian tissues : glutamine-utilizing carbamoyl phosphate synthetase of various experimental tumors : distribution, purification and characterization

1973 • 1 citations

Enzyme complexes of the pyrimidine pathway in ehrlich ascites tumor cells. Abstr.

1972 • 1 citations