Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Immunologic Purging of Marrow Assessed by PCR before Autologous Bone Marrow Transplantation for B-Cell Lymphoma

1991 • 712 citations

Marker Band in One Chromosome 14 from Burkitt Lymphomas

1972 • 628 citations

Detection of Minimal Residual Cells Carrying the t(14;18) by DNA Sequence Amplification

1987 • 426 citations

All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment

1991 • 347 citations

Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma

1993 • 340 citations

Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma

1994 • 302 citations

Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia.

1991 • 297 citations

New versatile cloning and sequencing vectors based on bacteriophage M13

1983 • 263 citations

Activation of thec-mycOncogene in a Precursor-B-Cell Blast Crisis of Follicular Lymphoma, Presenting as Composite Lymphoma

1988 • 258 citations

Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.

1988 • 245 citations

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1989 • 216 citations

The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining

1986 • 184 citations

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.

1992 • 167 citations

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1994 • 157 citations

The significance of circulating cells carrying t(14;18) in long remission from follicular lymphoma.

1991 • 153 citations

Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients.

1992 • 128 citations

Involvement of the bcl-2 Gene in Hodgkin's Disease

1990 • 126 citations

Detection of occult follicular lymphoma by specific DNA amplification

1988 • 116 citations

Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies.

1992 • 90 citations

Direct sequence analysis of the 14q+ and 18q- chromosome junctions in follicular lymphoma

1990 • 85 citations

Chromosomal Abnormalities in Patients With Hodgkin's Disease: Evidence for Frequent Involvement of the 14q Chromosomal Region but Infrequent bcl-2 Gene Rearrangement in Reed-Sternberg Cells

1992 • 73 citations

The reciprocal partners of both the t(14; 18) and the t(11; 14) translocations involved in B-cell neoplasms are rearranged by the same mechanism.

1988 • 65 citations

Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction.

1993 • 61 citations

T Cell Receptor Gene Trans-Rearrangements: Chimeric γ-δ Genes in Normal Lymphoid Tissues

1989 • 58 citations

Absence of t(14;18) major and minor breakpoints and of Bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease.

1991 • 52 citations

bcl-2 rearrangement in Hodgkin's disease. Results of polymerase chain reaction, flow cytometry, and sequencing on formalin-fixed, paraffin-embedded tissue.

1993 • 33 citations

Direct sequence analysis of the t(14;18) chromosomal translocation in Hodgkin's disease

1992 • 31 citations

The bcl-2 gene translocation is undetectable in Hodgkin's disease by Southern blot hybridization and polymerase chain reaction.

1992 • 29 citations

Detection of residual disease in translocation (14;18) positive non-Hodgkin's lymphoma, using the polymerase chain reaction: a comparison with conventional staging methods.

1992 • 28 citations

Detection of additional JH/BCL2 translocations in follicular lymphoma.

1991 • 28 citations

Expression of the bcl-2 oncogene product and chromosomal translocation t(14; 18) in Hodgkin's disease

1992 • 27 citations

Direct sequence analysis of 14q+ and 18q− chromosome junctions at the MBR and MCR revealing clustering within the MBR in follicular lymphoma

1991 • 18 citations