Glutathione S-Transferases and Anticancer Drug Resistance

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

(ADP-ribose)n participates in DNA excision repair

1980 • 1,112 citations

The Isoenzymes of Glutathione Transferase

1985 • 960 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

The Glutathione S ‐Transferases: A Group of Multifunctional Detoxification Proteins

1978 • 686 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

1985 • 501 citations

Microsomal Glutathione S-Transferase

2005 • 247 citations

Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital.

1984 • 235 citations

Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.

1984 • 222 citations

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

1978 • 188 citations

Glutathione S-transferases and carcinogenesis

1987 • 170 citations

Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.

1985 • 165 citations

The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms

1984 • 160 citations

Characterization of melphalan-glutathione adducts whose formation is catalyzed by glutathione transferases

1986 • 159 citations

Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites.

1985 • 156 citations

Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.

1987 • 155 citations

Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

1985 • 127 citations

Induction of rat hepatic glutathione S-transferase B by phenobarbital and 3-methylcholanthrene

1977 • 94 citations

Purification of glutathione S-transferases from rat lung by affinity chromatography. Evidence for an enzyme form absent in rat liver

1979 • 87 citations

Rat glutathione S-transferases supergene family. Characterization of an anionic Yb subunit cDNA clone.

1986 • 80 citations

On the multiplicity of rat liver glutathione S-transferases.

1985 • 60 citations

Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas.

1985 • 45 citations

Isolation and characterization of a Chinese hamster ovary cell line resistant to bifunctional nitrogen mustards.

1986 • 39 citations

Glutathione and glutathione transferase levels in mouse granulocytes following cyclophosphamide administration.

1986 • 39 citations

Glutathione S-transferases in human prostate

1987 • 37 citations

A Differential Staining Technique for Simultaneous Visualization of Mitotic Spindle and Chromosomes in Mammalian Cells

1981 • 33 citations

Repair replication and unscheduled DNA synthesis in mammalian cell lines showing differential sensitivity to alkylating agents

1973 • 32 citations

Comparative effects of alkylating agents and other anti-tumour agents on the intracellular level of adenosine 3′,5′-monophosphate in Walker carcinoma

1975 • 30 citations

Effects of BMY 25282, a mitomycin C analogue, in mitomycin C-resistant human colon cancer cells.

1985 • 30 citations

Induction of translationally active rat liver glutathione S-transferase B messenger RNA by phenobarbital

1981 • 29 citations

Occurrence of cytosolic protein and phosphoprotein changes in human colon tumor cells with the development of resistance to mitomycin C.

1985 • 29 citations

Alterations in adenosine 3′,5′-monophosphate-binding protein in Walker carcinoma cells sensitive or resistant to alkylating agents

1976 • 27 citations

Glutathione S-transferase in human organs.

1983 • 26 citations

Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards.

1982 • 23 citations

Acquired drug resistance is accompanied by modification in the karyotype and nuclear matrix of a rat carcinoma cell line

1983 • 19 citations

A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas

1986 • 16 citations

Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity.

1986 • 14 citations

Differences in the nuclear matrix phosphoproteins of a wild-type and nitrogen mustard-resistant rat breast carcinoma cell line.

1986 • 10 citations

Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines

1985 • 8 citations