Glucocorticoids and Mineralocorticoids: Actions on Brain and Behavior

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Frontiers in Neuroendocrinology, 1969.

1970 • 1,185 citations

The neurosciences. Third study program

1974 • 1,078 citations

Disrupted 24-hour Patterns of Cortisol Secretion in Psychotic Depression

1973 • 761 citations

Neuroendocrine Regulation in Depression

1976 • 628 citations

Anatomical neuroendocrinology

1982 • 592 citations

THE PHARMACOLOGICAL BASIS OF THERAPEUTICS

1976 • 542 citations

The Brain as a Target for Steroid Hormone Action

1979 • 520 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

A re-evaluation of the concept of ‘non-specificity’ in stress theory

1971 • 472 citations

Differences in Corticosterone and Dexamethasone Binding to Rat Brain and Pituitary¹

1975 • 456 citations

Transport of Steroid Hormones through the Rat Blood-Brain Barrier

1979 • 422 citations

Glucocorticoid hormone action

1976 • 318 citations

Psychobiology of memory: Towards a model of memory formation

1977 • 295 citations

The retention of an incompletely learned avoidance response.

1957 • 274 citations

Handbook of Physiology: Section 7: Endocrinology

1975 • 234 citations

The Roles of Plasma Binding and Receptor Specificity in the Mineralocorticoid Action of Aldosterone1

1973 • 232 citations

PITUITARY–ADRENAL SYSTEM HORMONES AND BEHAVIOR

1978 • 215 citations

Corticosterone Regulation of Tryptophan Hydroxylase in Midbrain of the Rat

1969 • 203 citations

Memory facilitating and anti-amnesic effects of corticosteroids

1978 • 196 citations

DYNAMIC ASYMMETRIES IN THE CORTICOSTEROID FEEDBACK PATH AND DISTRIBUTION METABOLISM‐BINDING ELEMENTS OF THE ADRENOCORTICAL SYSTEM*

1969 • 192 citations

Participation of the Dorsal Hippocampus in the Glucocorticoid Feedback Effect on Adrenocortical Activity

1980 • 190 citations

Evidence for a specific mineralocorticoid receptor in rat pituitary and brain

1980 • 187 citations

Influence of hormones on the nervous system

1973 • 183 citations

Activation of thymocyte glucocorticoid receptors to the steroid binding form. The roles of reduction agents, ATP, and heat-stable factors.

1979 • 171 citations

Autoradiographic localization of hormone‐concentrating cells in the brain of the female rhesus monkey

1976 • 169 citations

Adrenalcortical influence on rat brain tryptophan hydroxylase activity

1974 • 169 citations

PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITIS

1945 • 153 citations

GENETIC SUBTYPES OF UNIPOLAR PRIMARY DEPRESSIVE ILLNESS DISTINGUISHED BY HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITY

1979 • 152 citations

Neurochemistry of Learning and Memory: An Evaluation of Recent Data

1980 • 146 citations

Retention of corticosterone by cell nuclei from brain regions of adrenalectomized rats

1970 • 143 citations

Pituitary-adrenal hormones and extinction of rewarded behaviour in the rat

1974 • 142 citations

Psychiatric complications of medical drugs

1973 • 142 citations

Interactions in vivo and in vitro of corticoids and progesterone with cell nuclei and soluble macromolecules from rat brain regions and pituitary

1976 • 138 citations

GLUCOCORTICOIDS AS A REGULATORY FACTOR FOR BRAIN TRYPTOPHAN HYDROXYLASE

1976 • 133 citations

Acute Effect of a Glucocorticoid on Normal Human Sleep

1972 • 133 citations

DYNAMICS AND MECHANICS OF CORTICOSTEROID FEEDBACK AT THE HYPOTHALAMUS AND ANTERIOR PITUITARY GLAND

1977 • 133 citations

Mero-receptors: proteolytic fragments of receptors containing the steroid-binding site.

1978 • 131 citations

Some Effects of Adrenalectomy in the Fatty Rat*

1978 • 123 citations

The Site of the Suppressive Action of Dexamethasone on Pituitary-Adrenal Activity

1974 • 121 citations

VASOGENIC BRAIN OEDEMA: New aspects in its formation, resolution and therapy

1976 • 120 citations

Growth hormone and cortisol responsiveness in Cushing's syndrome

1972 • 118 citations

Modulation of corticotrophin-releasing factor release from hypothalamic synaptosomes

1974 • 118 citations

Corticosterone binding to hippocampus: nuclear and cytosol bindingin vitro

1973 • 117 citations

Pituitary-adrenal alterations and fear responding

1970 • 117 citations

Corticosterone binding to hippocampus: Immediate and delayed influences of the absence of adrenal secretion

1974 • 116 citations

The Effect of Endocrinological Manipulations on Tyrosine Hydroxylase and Dopamine-β-Hydroxylase Activities in Individual Hypothalamic Nuclei of the Adult Male Rat¹¹

1974 • 112 citations

A model of hormones and agonistic behavior

1975 • 110 citations

EFFECTS OF DEXAMETHASONE ON PHENYLETHANOLAMINE N‐METHYLTRANSFERASE AND ADRENALINE IN THE BRAINS AND SUPERIOR CERVICAL GANGLIA OF ADULT AND NEONATAL RATS

1975 • 110 citations

Control of Adrenocorticotropic Hormone Secretion

1966 • 108 citations

Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system

1975 • 106 citations

Soluble Corticosterone-Binding Macromolecules Extracted from Rat Brain

1972 • 105 citations

Regulation of 5-hydroxytryptamine metabolism in mouse brain by adrenal glucocorticoids

1975 • 103 citations

Corticoid Receptors in Rat Brain: Evidence for an Aldosterone Receptor

1976 • 101 citations

Steroid-sensitive neurones in rat brain: Anatomical localization and responses to neurohumours and ACTH

1969 • 101 citations

Interrelationships Between the Endocrine System and Neuropsychiatry

1963 • 99 citations

Adrenocortical hormones and avoidance behaviour of rats

1968 • 98 citations

Aldosterone biosynthesis

1972 • 96 citations

The Effects of Corticosteroids on Myelination of the Developing Rat Brain

1973 • 95 citations

Compensatory adrenal growth: a neurally mediated reflex

1976 • 94 citations

Glucocorticoid binding to receptor-like proteins in rat brain and pituitary: Ontogenetic and experimentally induced changes

1976 • 94 citations

Dose-dependent action of corticosteroids on brain serotonin content and passive avoidance behavior

1977 • 93 citations

Evidence for interactions between central noradrenergic neurons and adrenal hormones in learning and memory

1977 • 91 citations

Effect of mineralocorticoids on spontaneous sodium chloride appetite of adrenalectomized rats

1966 • 91 citations

Adrenocortical activity and avoidance learning as a function of time after fear conditioning

1966 • 87 citations

Synchronized Ultradian Cortisol Rhythms in Monkeys: Persistence During Corticotropin Infusion

1977 • 84 citations

Hormonal control of submissiveness in mice: Irrelevance of the androgens and relevance of the pituitary-adrenal hormones

1979 • 83 citations

Adrenalectomy, dexamethasone or stress alters opioid peptides levels in rat anterior pituitary but not intermediate lobe or brain

1979 • 82 citations

Modulation of behavioral inhibition in appetitive extinction following manipulation of adrenal steroids in rats: Implications for involvement of the hippocampus.

1979 • 82 citations

Relationship between Circadian Rhythm of Food Intake and that of Plasma Corticosterone and Effect of Food Restriction on Circadian Adrenocortical Rhythm in the Rat

1977 • 80 citations

Radioautographic study of the rat brain and pituitary after injection of 3H dexamethasone

1975 • 80 citations

The effects of ACTH, adrenalectomy and dexamethasone on the acquisition of an avoidance response in rats

1970 • 77 citations

Chronic and Acute Dexamethasone Suppression of Stress Activation of the Adrenal Cortex in Young and Aged Rats

1972 • 75 citations

The adrenals and the regulatory nature of running wheel activity

1971 • 75 citations

The Effects of Neonatal Hydrocortisone on Rat Cerebellar Development

1978 • 74 citations

Putative Glucocorticoid Receptors in Hippocampus and Other Regions of the Rat Brain

1975 • 73 citations

Mammalian behavior and the adrenal cortex—A review

1972 • 72 citations

Adrenal steroids indirectly modulate morphine and beta-endorphin effects.

1979 • 72 citations

On the role of brain noradrenaline and the pituitary-adrenal axis in avoidance learning. I. Studies with corticosterone

1977 • 70 citations

Modulation of high affinity GABA uptake into hippocampal synaptosomes by glucocorticoids

1978 • 69 citations

Adrenocortical activity and avoidance learning as a function of time after avoidance training☆

1967 • 68 citations

Anatomical Distribution of Corticosterone-Concentrating Neurons in Rat Brain1

2015 • 68 citations

Localization and role of transcortin-like molecules in the anterior pituitary

1977 • 66 citations

Effects of adrenalectomy and experience on postcastration sex behavior in the male rat☆

1968 • 66 citations

Adrenal-pituitary influence in reactivation of avoidance-learning memory in the rat after intermediate intervals.

1972 • 66 citations

Properties of corticosterone-binding macromolecules from rat brain cytosol

1973 • 65 citations

The effects of progestins, mineralocorticoids, glucocorticoids, and steroid solubility on the induction of sexual receptivity in rats

1977 • 65 citations

On the control of brain serotonin turnover rate by end product inhibition

1972 • 65 citations

Pituitary-Adrenal Influences on Avoidance and Approach Behavior of the Rat

1973 • 65 citations

Effect of corticosterone on the synthesis of [3H]catecholamines in the brains of CD-1 mice

1977 • 63 citations

Effect of Hormonal State on Cell Number and Functional Maturation of the Brain

1972 • 62 citations

Acute Self-Suppression of Corticosteroidogenesis in Isolated Adrenocortical Cells*

1979 • 62 citations

Multiple retention deficits following one-trial appetitive training

1975 • 61 citations

Effects of adrenalectomy on the turnover of norepinephrine in the rat brain

1968 • 60 citations

EVIDENCE FOR THE ROLE OF ADRENOCORTICAL HORMONES IN THE REGULATION OF NORADRENALINE AND DOPAMINE METABOLISM IN CERTAIN BRAIN AREAS

1978 • 58 citations

Effect of corticosteroids in the hippocampus on passive avoidance behavior in the rat

1977 • 58 citations

Amnesic effect of cycloheximide in the mouse mediated by adrenocortical hormones.

1975 • 57 citations

Adrenocorticoids control 5-hydroxytryptamine metabolism in rat brain

1978 • 57 citations

The ontogeny of corticosterone and dexamethasone receptors in rat brain

1977 • 56 citations

Effects of adrenocorticotropic hormone on avoidance behaviour of intact and adrenal-ectomized rats

1968 • 56 citations

Autoradiographic studies of 3H-dexamethasone uptake by immunocytochemically characterized cells of the rat pituitary

1977 • 56 citations

Dissociation of open-field behavior and pituitary-adrenal function

1973 • 55 citations

Differences between cytosol receptor complexes with corticosterone and dexamethasone in hippocampal tissue from rat brain

1976 • 55 citations

ANATOMICAL AND BEHAVIOR CHANGES PRODUCED IN THE RAT BY COMPLETE AND PARTIAL EXTIRPATION OF THE PITUITARY GLAND

1930 • 54 citations

Central Nervous Structures and the Effect of ACTH and Corticosteroids on Avoidance Behaviour: A study with Intracerebral Implantation of Corticosteroids in the Rat

1970 • 52 citations

Pituitary-adrenal activity under different appetitive extinction procedures

1976 • 51 citations

Autoradiographic demonstration of aldosterone-concentrating neuron populations in rat brain

1978 • 51 citations

ACTH induced sodium appetite in the rat

1978 • 50 citations

A comparison of the glucocorticoid receptor in cytosol from rat liver and hippocampus

1979 • 49 citations

Glucocorticoid Receptors

1979 • 49 citations

5-hydroxytryptamine and the mediation of pituitary-adrenocortical hormones in the extinction of active avoidance behaviour

1976 • 48 citations

Autoradiographic Studies with 3H-Dexamethasone in the Rat Brain and Pituitary1

2015 • 48 citations

Adrenal Regulation of Regional Brain Angiotensinogen Content*

1980 • 47 citations

Learning, brain noradrenaline and the pituitary--adrenal axis.

1974 • 47 citations

MAINTENANCE OF MALE SEXUAL BEHAVIOUR BY COMBINED TREATMENT WITH OESTROGEN AND DIHYDROTESTOSTERONE IN CD-1 MICE

1975 • 47 citations

Nuclear localization of aldosterone in rat brain cells assessed by autoradiography

1979 • 45 citations

Glucocorticoids and Mammalian Motor Nerve Excitability

1975 • 45 citations

Reduced glucocorticoid binding site concentration in cortical neuronal perikarya from senescent rats

1976 • 45 citations

Effects of Steroids on Extinction of an Avoidance Response in Rats.: A Structure–Activity Relationship Study

1970 • 45 citations

The Role of ACTH and Adrenal Glucocorticoids in the Salt Appetite of Wild Rabbits [Oryctolagus cuniculus (L)]

1975 • 45 citations

Corticosteroid binding in rat brain and pituitary cytosols: resolution of multiple binding components by polyacrylamide gel based isoelectric focusing

1977 • 44 citations

Steroid hormone target cells in the extrahypothalamic brain stem and cervical spinal cord: Neuroendocrine significance

1979 • 44 citations

Reversal of amnesia by an orally active ACTH 4–9 analog (Org 2766)

1976 • 43 citations

MOUSE BRAIN TYROSINE HYDROXYLASE AND GLUTAMIC ACID DECARBOXYLASE FOLLOWING TREATMENT WITH ADRENOCORTICOTROPHIC HORMONE, VASOPRESSIN OR CORTICOSTERONE

1978 • 43 citations

Effects of ACTH on the Sleep of Normal Subjects and Patients with Addison’s Disease

1974 • 42 citations

The autoradiographic localization of [3H]dexamethasone in the brain and pituitary of the rat

1975 • 40 citations

Corticosteroids in Brain Tissue

1975 • 39 citations

Effect of dexamethasone on monoamine oxidase inhibition by iproniazid in rat brain

1977 • 39 citations

CIRCADIAN RHYTHM OF CORTICOSTERONE LEVELS IN RAT BRAIN

1976 • 38 citations

Adrenalectomy: Protection from kindled convulsion induced amnesia in rats

1976 • 37 citations

Hydrocortisone-Mediated Increase of Norepinephrine Uptake by Brain Slices

1971 • 37 citations

EARLY RESPONSE OF RAT BRAIN TRYPTOPHAN HYDROXYLASE ACTIVITY TO CYCLOHEXIMIDE, PUROMYCIN AND CORTICOSTERONE

1976 • 37 citations

Uptake of tritiated steroids in the brain of the duck (Anas platyrhynchos). An autoradiographic study

1972 • 35 citations

Effects of several pregnane and pregnene steroids on estrous behavior in ovariectomized, estrogen-primed guinea pigs

1972 • 35 citations

Demonstration of the Kamin effect after one-trial avoidance learning

1966 • 35 citations

Deficiency of Deoxycorticosterone-Binding Protein in the Hypothalamus of Rats Resistant to Deoxycorticosterone-Induced Hypertension¹

1974 • 34 citations

RNA and DNA synthesis in developing rat brain: hormonal influences

1978 • 34 citations

The effect of corticosteroids on dendritic development in the rat brain.

1974 • 34 citations

TSH and TRH: Their Physiological Regulation and the Clinical Applications of TRH

1977 • 34 citations

The Intracellular Distribution of Natural and Synthetic Glucocorticoids in the AtT-20 Cell*

1979 • 33 citations

Modulation of the hydrocortisone induction of glycerol phosphate dehydrogenase by N6,O2'-dibutyryl cyclic AMP, norepinephrine, and isobutylmethylxanthine in rat brain cell cultures.

1978 • 33 citations

Ontogeny of Glucocorticoid Binding in Rodent Brain

1978 • 33 citations

Effects of cortisol on unit activity in the hypothalamus of the rat

1970 • 32 citations

Glucocorticoid regulation of the serotonergic system of the brain.

1976 • 32 citations

Corticoid binding component in rat brain

1972 • 32 citations

Correlation between hypothalamic serotonin content and adrenal function during acute stress. Effect of adrenal corticosteroids on hypothalamic serotonin content.

1973 • 31 citations

Cue value of dexamethasone for fear-motivated behavior

1971 • 31 citations

ADRENOCORTICAL INFLUENCES ON FREE‐OPERANT AVOIDANCE BEHAVIOR¹

1967 • 31 citations

Inhibitors of protein synthesis and memory: dissociation of amnesic effects and effects on adrenal steroidogenesis

1976 • 30 citations

Handbook of Neurochemistry

1973 • 30 citations

Hormonal Inputs to Releasing Factor Cells, Feedback Sites

1973 • 29 citations

Effects of hydrocortisone and immobilization on tryptophan metabolism in brain and liver of rats of different ages

1975 • 29 citations

Glucocorticoid modulation of specific protein metabolism in hippocampal slices maintained in vitro

1979 • 29 citations

Dexamethasone stimulation of running activity in the male rat

1970 • 28 citations

The effects of cell membrane alteration on glucocorticoid uptake by the AtT-20/D-1 target cell

1977 • 28 citations

Effects of intracerebral implantation of corticosteroids on extinction of an avoidance response in rats

1969 • 27 citations

Effects of Hydrocortisone on Biogenic Amine Levels in the Hypothalamus

1975 • 26 citations

Glucocorticoids and hippocampal enzyme activity

1979 • 26 citations

Regional high-affinity [3H]choline accumulation in cat forebrain: selective increase in the caudate-putamen after corticosteroid pretreatment.

1979 • 26 citations

Adrenal mediation of estrogen-induced ejaculatory behavior in the male rat

1975 • 26 citations

Hypophysectomy and rat brain metabolism: effects of synthetic ACTH analogs.

1972 • 25 citations

Adrenalectomy and the Suppression of Memory by Puromycin

1970 • 25 citations

Dexamethasone inhibits multi-unit activity in the rat hippocampus

1974 • 25 citations

Effect of cortisol on the excitability of limbic structures of the brain in freely moving rats

1975 • 24 citations

Differential effects of dexamethasone and body weight loss on two measures of activity

1971 • 24 citations

The uptake of hydrocortisone in mouse brain and ependymoblastoma

1972 • 24 citations

The role of the pituitary-adrenal system in the footshock-induced increase of [3H]lysine incorporation into mouse brain and liver proteins

1977 • 24 citations

The Hippocampus and Hormonal Cyclicity

1975 • 23 citations

Effects of hydrocortisone and electric footshock on mouse brain tyrosine hydroxylase activity and tyrosine levels

1977 • 23 citations

BRAIN ADRENOCORTICOTROPHIN AFTER ADRENALECTOMY AND SHAM-OPERATION OF RATS

1981 • 23 citations

The Binding of Corticosterone to Brain Proteins: Diurnal Variation1

1973 • 23 citations

Effect of corticosteroids on passive avoidance behavior of rats.

1970 • 22 citations

Effect of cortisol on single cell activity in hypothalamic islands

1970 • 22 citations

Biochemical Effects of Adrenocortical Steroids on the Central Nervous System

1972 • 21 citations

Metabolic effects of hydrocortisone in mouse brain

1977 • 21 citations

Catecholamine concentration of various brain nuclei of the rat as affected by ACTH and corticosterone

1978 • 20 citations

Adrenal and amygdala function in the incubation of aversively conditioned responses

1970 • 20 citations

Neonatal corticosteroid permanently alters brain activity of epinephrine-synthesizing enzyme in stressed rats

1979 • 19 citations

Endocrine control of psychomotor activity in the rat: Effects of chronic dexamethasone upon general activity

1978 • 19 citations

Behavioral effects of lesions of the locus ceruleus noradrenaline system combined with adrenalectomy

1979 • 19 citations

Effect of prestimulation on avoidance responding in rats, and hormonal dependence of the effect.

1976 • 19 citations

Adrenalectomy: Protection from kindled convulsion induced dissociation in rats☆

1978 • 19 citations

Iontophoretically Applied Corticosteroids Do Not Affect the Firing of Hippocampal Neurons

1977 • 19 citations

Adrenalectomy-induced deficits in maternal retrieval in the rat

1977 • 19 citations

Effects of adrenalectomy on open-field behavior in rats

1972 • 19 citations

Adrenal modulation of brain size in adult rats

1979 • 17 citations

Effects of Cortisone and of Adrenalectomy on Activity and Emotional Behavior of Mice

1956 • 17 citations

Adrenalectomy attenuates electroconvulsive shock-induced retrograde amnesia in rats

1978 • 17 citations

The amnestic effect of protein synthesis inhibitors is not due to the inhibition of adrenal corticosteroidogenesis

1977 • 17 citations

Hippocampal cytosol binding capacity of corticosterone: no depletion with nuclear loading

1980 • 15 citations

Protein synthesis and amnesia: Studies with emetine and pactamycin

1977 • 14 citations

Pituitary-adrenal influences on avoidance behavior of pigs

1978 • 14 citations

Brain glucocorticoid receptor: correlation of in vivo uptake of corticosterone with behavioral, endocrine, and neuropharmacological events.

1980 • 14 citations

Effect of variations in adrenocortical function on dopamine beta-hydroxylase and norepinephrine in the brain of the rat.

1976 • 14 citations

Pituitary-adrenocortical axis and shock-induced fighting in rats

1978 • 13 citations

Dose-dependent dual effect of corticosterone on cerebral 5-HT metabolism

1977 • 13 citations

Allosteric and Competitive Steroid-Receptor Interactions

1979 • 13 citations

Binding of natural and synthetic glucocorticoids in rat brain

1975 • 12 citations

Effect of cortisol on unit activity in freely moving rats

1971 • 12 citations

Pituitary-adrenal effects on sexual behavior in isolated and group-housed mice

1979 • 12 citations

Adrenal corticosteroids and the Kamin effect

1971 • 11 citations

Effects of dexamethasone on fear conditioning in pigs

1977 • 10 citations

Influence of Change in Feeding Regime and Food Deprivation on Circadian Rhythm of Adrenal Cortical Activity in Rats

1976 • 9 citations

Aldosterone?A new therapeutic principle for the treatment of brain oedema in man

1974 • 9 citations

Occurrence and function of corticosteroids in some selected mammalian species

1969 • 9 citations

Breakdown of Blood–Cerebrospinal Fluid Barrier for Calcium Ions in the Absence of Glucocorticoids

1967 • 8 citations

Influence of corticosterone on the development and display of androgen-dependent aggressive behavior in mice☆

1978 • 8 citations

Significance of neuropeptides in the control of corticosterone receptor activity in rat brain.

1980 • 8 citations

Relationship of nycthemeral cycles of running activity and plasma corticosterone concentration following basal hypothalamic isolation*1

1972 • 7 citations

Retention of aversively motivated behavior: Effects of time of training and associative versus nonassociative processes

1977 • 7 citations

Polyadenylic acid synthesis activity of purified DNA-dependent RNA polymerase from Caulobacter.

1978 • 7 citations

Retention of appetitive instrumental behavior: The Kamin effect

1979 • 7 citations

Blockage of pituitary-adrenal activity does not affect conditioned suppression☆

1978 • 7 citations

Behavioral and other systemic effects of cortisol-21-sulfate

1972 • 7 citations

Effects of Dexamethasone and Stressful Stimuli on Hypothalamic Electrical Activity in Rats with Diencephalic Islands

1972 • 7 citations

Attenuation of amnesia by hydrocortisone in the mouse

1978 • 7 citations

Inhibitory Mechanisms of Dexamethasone on Contractions Induced by Drugs and by Transmural Stimulations in Isolated Guinea Pig Ileum.

1978 • 6 citations

SELECTIVE PURIFICATION OF A SINGLE POPULATION OF GLUCOCORTICOID RECEPTORS FROM RAT BRAIN

1978 • 6 citations

Betamethasone-induced pituitary-adrenocortical suppression and brain 5-hydroxytryptamine in the rat

1979 • 5 citations

Pituitary-adrenal influences on the acquisition of excitatory and inhibitory conditioned responses in rats

1979 • 4 citations

Failure to interpret the behavioural effect of cortisol-21-sulphate by steroid-receptor interaction

1978 • 3 citations