Glucocorticoid Receptors

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Steroid–Cell Interactions

1974 • 592 citations

Membrane receptors for hormones and neurotransmitters.

1976 • 573 citations

Glucocorticoid receptors: Relations between steroid binding and biological effects

1972 • 554 citations

Scatchard plots: Common errors in correction and interpretation

1975 • 411 citations

Relation of steroid structure to enzyme induction in hepatoma tissue culture cells

1970 • 399 citations

Specific and Nonspecific Physicochemical Interactions of Glucocorticoids and Related Steroids with Rat Thymus Cells in Vitro

1968 • 381 citations

Glucocorticoid-binding Proteins of Rat Liver Cytosol

1972 • 328 citations

Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells

1971 • 328 citations

Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action

1975 • 284 citations

General Presence of Glucocorticoid Receptors in Mammalian Tissues¹

1974 • 272 citations

Role of DNA and Specific Cytoplasmic Receptors in Glucocorticoid Action

1972 • 248 citations

Receptors and mechanism of action of steroid hormones

1977 • 247 citations

Glucocorticoid Receptors in Lymphoma Cells in Culture: Relationship to Glucocorticoid Killing Activity

1971 • 239 citations

The Roles of Plasma Binding and Receptor Specificity in the Mineralocorticoid Action of Aldosterone1

1973 • 232 citations

Steroid-induced nuclear binding of glucocorticoid receptors in intact hepatoma cells

1973 • 221 citations

Glucocorticoid-binding Proteins of Rat Liver Cytosol

1972 • 206 citations

Glucocorticoid-Binding Proteins in Human Acute Lymphoblastic Leukemic Blast Cells

1973 • 192 citations

Evidence that dephosphorylation inactivates glucocorticoid receptors.

1977 • 170 citations

Glucocorticoid Receptors and Inhibition of Bone Cell Growth in Primary Culture¹²

1977 • 167 citations

Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unstimulated human lymphocytes

1977 • 166 citations

The Relationship between Glucocorticoid Binding and Tyrosine Aminotransferase Induction in Hepatoma Tissue Culture Cells

1970 • 166 citations

Steroid-binding properties and stabilization of cytoplasmic glucocorticoid receptors from rat thymus cells

1973 • 155 citations

Glucocorticoid and mineralocorticoid receptors for aldosterone

1972 • 149 citations

Metabolic Site and Time Course of Cortisol Action on Glucose Uptake, Lactic Acid Output, and Glucose 6-Phosphate Levels of Rat Thymus Cells in Vitro

1968 • 148 citations

Structure-activity relationships for glucocorticoids—I: Determination of receptor binding and biological activity

1977 • 147 citations

Liver Cytosol Corticosteroid Binder II, a Hormone Receptor

1973 • 142 citations

Peripheral Actions of Glucocorticoids

1975 • 139 citations

Cytoplasmic receptor for glucocorticoids in lung of the human fetus and neonate.

1974 • 136 citations

Mechanism of Resistance to Steroids: Glucocorticoid Receptor Defect in Lymphoma Cells

1972 • 135 citations

A Radioreceptor Assay for Evaluation of the Plasma Glucocorticoid Activity of Natural and Synthetic Steroids in Man1

1975 • 135 citations

Evidence for a New Class of Corticosterone Receptors in the Rat Kidney1

1973 • 132 citations

Specific Binding Sites for Natural Glucocorticoids in Plasma Membranes of Rat Liver¹

1975 • 127 citations

Interaction of anabolic steroids with glucocorticoid receptor sites in rat muscle cytosol

1975 • 124 citations

Specific Glucocorticoid Receptors in Thymus Cells

1970 • 109 citations

Alteration in glucocorticoid binding site number during the cell cycle in HeLa cells

1977 • 107 citations

Soluble Corticosterone-Binding Macromolecules Extracted from Rat Brain

1972 • 105 citations

Glucocorticoid and Mineralocorticoid Receptors in Gut Mucosa¹

1975 • 102 citations

Specificity and thermodynamic properties of the corticosteroid binding to a receptor of rat thymocytes in vitro

1968 • 100 citations

Glucocorticoid Receptors in Rat Thymocytes

1974 • 97 citations

The Role of Sulfhydryl Groups in the Binding of Glucocorticoids by Cytoplasmic Receptors of Lung and Other Mammalian Tissues¹

1977 • 97 citations

How specific are nuclear “receptors” for thyroid hormones?

1975 • 96 citations

Dexamethasone Phosphate-induced Synthesis of Tyrosine Aminotransferase in Hepatoma Tissue Culture Cells

1970 • 95 citations

The involvement of receptor sulphydryl groups in the binding of steroids to the cytoplasmic glucocorticoid receptor from rat thymus

1975 • 93 citations

Correlation between glucocorticoid binding to specific liver cytosol receptors and enzyme induction in vivo

1972 • 92 citations

Duncanʼs Diseases of Metabolism

1970 • 90 citations

Interaction of steroids with hepatoma cells: Molecular mechanisms of glucocorticoid hormone action

1975 • 89 citations

Binding of Glycyrrhetinic Acid to Kidney Mineralocorticoid and Glucocorticoid Receptors¹

1975 • 87 citations

Palatal cytosol cortisol-binding protein associated with cleft palate susceptibility and H–2 genotype

1977 • 84 citations

Formation and characterisitcs of hepatic dexamethasone-receptor complexes of different molecular weight

1977 • 84 citations

A study of the cytoplasmic receptors for glucocorticoids in intestine of pre- and postweanling rats.

1975 • 84 citations

Glucocorticoid Receptors in Lung

1973 • 79 citations

The kinetics of glucocorticoid binding to the soluble specific binding protein of mouse fibroblasts.

1975 • 77 citations

Investigations on the glucocorticoid-binding protein from rat thymocytes

1972 • 77 citations

Chromatographic separation on phosphocellulose of activated and nonactivated forms of steroid-receptor complex. Purification of the activated complex

1976 • 75 citations

Corticosteroid receptors in the neural retina and other tissues of the chick embryo

1975 • 74 citations

Glucocorticoid receptors in murine embryonic facial mesenchyme cells

1976 • 70 citations

Glucocorticoid Receptors: Evidence for a Second, Non-Glucocorticoid Binding Site

1976 • 68 citations

Glucocorticoid Receptors in Pituitary Tumor Cells

1973 • 68 citations

Reductions in Glucocorticoid Inhibition of Glucose Oxidation and Presumptive Glucocorticoid Receptor Content in Rat Adipocytes During Aging

1976 • 62 citations

Specific binding of glucocorticoids in vitro in the soluble fraction of mouse fibroblasts

1972 • 62 citations

Ontogeny of glucocorticoid receptors in rat liver.

1975 • 61 citations

The Glucocorticoid Receptor

1975 • 60 citations

Invitro binding of cortisol-1, 2-3H by a substance in the supernatant fraction of P1798 mouse lymphosarcoma

1966 • 59 citations

Stereospecific Glucocorticoid Binding to Subcellular Fractions of the Sensitive and Resistant Lymphosarcoma P1798

1971 • 58 citations

Two sex steroid receptors in SC-115 mammary tumor cells

1976 • 57 citations

Uptake of Cortisol by Isolated Rat Liver Cells. A Phenomenon Indicative of Carrier-Mediation and Simple Diffusion

1976 • 57 citations

Relationship between receptor and mammary tumour virus production after stimulation by glucocorticoid

1976 • 53 citations

Dramatic protective effect of ligand against thermal degradation on mineralo- and glucocorticoid receptors of rat kidney

1977 • 53 citations

Characterization of a distinct glucocorticoid-binding protein in the lactating mammary gland of the rat

1973 • 53 citations

Liver cytosol corticosteroid binder IB, a new binding protein.

1975 • 52 citations

Glucocorticoid-binding Macromolecules in Normal Tissues and Tumors

1972 • 51 citations

Characterization and partial purification of the specific glucocorticoid-binding component from mouse fibroblasts

1971 • 50 citations

Use of the direct linear plot to estimate binding constants for protein-ligand interactions

1976 • 48 citations

Cellular Site of Glucocorticoid-Receptor Complex Formation

1972 • 46 citations

Nuclear Binding of Steroid Receptors: Comparison in Intact Cells and Cell-Free Systems

1973 • 46 citations

Partial purification of a glucocorticoid receptor.

1975 • 46 citations

Stabilization and characterization of the dexamethasone-binding proteins in rat liver cytosol

1976 • 45 citations

Glucocorticoid Receptors in Mouse Mammary Tumors

1974 • 44 citations

Comparison of glucocorticoid-binding proteins in normal and neoplastic mammary tissues of the rat

1975 • 43 citations

[3H] cortisol binding by young and old human liver cytosol proteins in vitro

1973 • 43 citations

Variants of HTC Cells With Low Tyrosine Aminotransferinase Inducibility and Apparently Normal Glucocorticoid Receptors

1977 • 42 citations

Mineralocorticoid and glucocorticoid receptors in human kidney

1976 • 41 citations

Steroids and the practical aspects of performing binding studies

1976 • 40 citations

Physicochemical Properties of Glucocorticoid Receptors from Mouse Fibroblasts*

1977 • 40 citations

Autoradiographic Localization of Corticosterone Receptors (Type III) to the Collecting Tubule of the Rat Kidney

1975 • 40 citations

Evidence for a phospholipid requirement in the specific binding of glucocorticoids to receptors of fibroblasts and thymic lymphocytes.

1976 • 39 citations

Reduced glucocorticoid responsiveness and receptor concentration in splenic leukocytes of senescent rats

1975 • 37 citations

A soluble receptor for corticoids in the neural retina of the chick embryo

1972 • 37 citations

Relationships between steroid binding and elevation of alkaline phosphatase in HeLa cells

1969 • 36 citations

The role of transcortin in glucocorticoid mediated enzyme induction: Tyrosine aminotransferase induction in hepatoma tissue culture cells

1974 • 36 citations

Effect of chemical inactivating agents on glucocorticoid receptor proteins in mouse and hamster cells.

1975 • 36 citations

The Coexistence of Androgen and Glucocorticoid Receptors in the DDT₁Cloned Cell Line¹

1977 • 35 citations

Two sex steroid receptors in mouse fibroblasts in culture

1976 • 34 citations

Ligandin and Z protein in binding of thyroid hormones by the liver

1976 • 31 citations

The steroid induction of glutamine synthetase in chick embryo retinas in culture a possible role of corticosteroid-binding globulin

1969 • 31 citations

Identification of breast cancer transcortin and its inhibitory role in cell-mediated immunity

1976 • 30 citations

Glucocorticoids—uptake by simple diffusion by cultured reuber and novikoff rat hepatoma cells

1976 • 30 citations

Cytoplasmic Glucocorticoid Receptors in the Developing Small Intestine of the Rabbit Fetus

1976 • 29 citations

Differences between Cytoplasmic Glucocorticoid-binding Proteins shown by Heterogeneity of Nuclear Acceptor Sites

1973 • 29 citations

Partial purification of the activated glucocorticoid receptor of rat liver

1976 • 27 citations

Human liver nuclear transcortin its postulated role in glucocorticoid regulation of genetic activity

1974 • 26 citations

In vitro degradation and stabilization of the glucocorticoid binding component from mouse fibroblasts

1973 • 26 citations

Regulation of Gene Expression by Glucocorticoid Hormones: Studies of Receptors and Responses in Cultured Cells

1978 • 25 citations

[20] Measurement of specific binding of a ligand in intact cells: Dexamethasone binding by cultured hepatoma cells

1975 • 25 citations

The principal glucocorticoid binding macromolecule in hepatoma cells in culture is similar to corticosteroid Binder II of rat liver cytosol

1973 • 24 citations

Partial purification of the activated hepatic glucocorticoid-receptor complex

1976 • 23 citations

Interactions of Corticosterone, 5alpha-Dihydrocorticosterone and Dexamethasone with Proteins in Rat-Liver Cytosol

1977 • 23 citations

Steroid Receptors and Hormone Receptivity

1975 • 23 citations

Effect of salt on reversibility of glucocorticoid receptor binding

1976 • 22 citations

Cytoplasmic receptor levels and glucocorticoid response in human lymphoblastoid cell lines

1975 • 20 citations

Hormonal regulation of the affinity and concentration of hormone receptors in target cells

1976 • 20 citations

Evidence that natural vs synthetic steroid hormones bind to physicochemically distinct cellular receptors

1976 • 20 citations

Hepatic Glucocorticoid Binders in Mature and Senescent C57BL/6J Male Mice

1976 • 19 citations

Mammary glucocorticoid receptor of mice in pregnancy and in lactation

1976 • 17 citations

The Problem of Pain

1973 • 16 citations

Evidence for a Glucocorticoid Receptor in Human Leukocytes

1976 • 16 citations

Partial purification of the glucocorticoid receptor from rat liver: A rapid, two-step procedure using DNA-cellulose

1976 • 15 citations

The dexamethasone receptor in the Novikoff Hepatoma. Characterization and changes in concentration and nuclear uptake during glucocorticoid therapy

1975 • 13 citations

[19] A filter technique for measurement of steroid-receptor binding

1975 • 13 citations

Glucocorticoid binding in the chicken liver cytosol

1976 • 12 citations

Partial purification of rat liver glucocorticoid binding proteins by affinity chromatography

1976 • 12 citations

Interaction of cortisol with the neural retina of the chick embryo in culture

1975 • 11 citations

Mechanism of Glucocorticoid Hormone Action and of Regulation of Gene Expression in Cultured Mammalian Cells

1973 • 11 citations

Effect of temperature on glucocorticoid uptake and glucocorticoidreceptor translocation in rat thymocytes

1976 • 10 citations

Effect of endogenous corticosterone on the determination of dexamethasone receptor levels in rat liver cytosol

1976 • 8 citations

Is cortisol metabolized as it dissociates from glucocorticoid receptors in thymus cells?

1974 • 8 citations

Impairment of enzyme induction by glucocorticoids in Zajdela hepatoma cells

1976 • 7 citations

Steroid-binding properties of corticosteroid receptors in different target tissues of the rat

1975 • 7 citations

Principles of physical chemistry

1959 • 6 citations

Drug Design: Developing New Criteria

1977 • 6 citations

The effect of hormones on glucocorticoid binding capacity of rat liver cytosol

1975 • 5 citations

Hydrocortisone binding receptor in the rat pituitary GH3 cell line

1976 • 2 citations