The Design of Tumor-Inhibitory Alkylating Drugs

Structural considerations in the interaction of DNA and acridines

1961 • 2,199 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 728 citations

The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides

1946 • 717 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 653 citations

Intracellular pH.

1969 • 394 citations

Design of Active-Site-Directed Irreversible Enzyme Inhibitors.

1967 • 387 citations

Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.

1963 • 369 citations

Studies related to the mechanisms of action of cytotoxic alkylating agents: a review.

1962 • 304 citations

Genetic and Allied Effects of Alkylating Agents

1966 • 216 citations

MYLERAN IN CHRONIC MYELOID LEUKÆMIA CHEMICAL CONSTITUTION AND BIOLOGICAL ACTION

1953 • 214 citations

Biological Alkylating Agents

1962 • 209 citations

Chemistry of nucleosides and nucleotides

1995 • 206 citations

Advances in Chemotherapy of Cancer in Man

1956 • 193 citations

Cyto-active amino-acid and peptide derivatives. Part I. Substituted phenylalanines

1954 • 163 citations

The Chemistry of Cytotoxic Alkylating Agents

1953 • 153 citations

Chemotherapeutic Action of a Cyclic Nitrogen Mustard Phosphamide Ester (B 518-ASTA) in Experimental Tumours of the Rat

1958 • 151 citations

CARCINOGENIC EPOXIDES, LACTONES, AND HALO‐ETHERS AND THEIR MODE OF ACTION*

1969 • 139 citations

Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

1966 • 139 citations

Preparation of N-Phosphorylated Derivatives of Bis-β-chloroethylamine^1a

1954 • 137 citations

2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256

1969 • 133 citations

464. The reactions of certain epoxides in aqueous solutions

1950 • 132 citations

Neuartige Krebs-Chemotherapeutika aus der Gruppe der zyklischen N-Lost-Phosphamidester

1958 • 118 citations

Long-term survival of patients with Burkitt's lymphoma: an assessment of treatment and other factors which may relate to survival.

1967 • 117 citations

THE MECHANISM OF ACTION OF ALKYLATING AGENTS.

1963 • 114 citations

A Study of Comparative Chemical and Biological Activities of Alkylating Agents¹

1965 • 113 citations

Biological approaches to cancer chemotherapy

1962 • 101 citations

Effects upon tumours of Various Haloalkylarylamines

1948 • 100 citations

STUDIES ON THE ANTI-TUMOUR ACTIVITY OF p-DI-(2-CHLOROETHYL) AMINOPHENYLALANINE (SARCOLYSINE)

1955 • 87 citations

Protection against the toxicity of alkylating agents by thiols: The mechanism of protection and its relevance to cancer chemotherapy

1966 • 86 citations

ALKYLATING AGENTS

1964 • 79 citations

The mode of action of alkylating agents—III

1961 • 65 citations

Reduction of Cytotoxic Azo Compounds by Hydrazine and by the Xanthine Oxidase–Xanthine System

1955 • 64 citations

Potential Anticancer Agents --L. Non-Classical Antimetabolites--II. Some Factors in the Design of Exo-Alkylating Enzyme Inhibitors, partcularly of Lactic Dehydrogenase

1960 • 63 citations

Toxicity, hæmatological effects and anti-tumour activity of epoxides derived from disubstituted hexitols. Mode of action of mannitol myleran and dibromomannitol

1968 • 56 citations

Cure of Mice Bearing Advanced Plasma Cell Tumours With Aniline Mustard

1965 • 55 citations

Some Serum Protein Nitrogen Mustard Complexes with High Chemotherapeutic Selectivity

1967 • 50 citations

Microsomal activation of cyclophosphamide in vivo

1970 • 49 citations

Increased sensitivity of the Walker tumour towards aromatic nitrogen mustards carrying basic side chains following glucose pretreatment

1961 • 47 citations

The effect of glucose pretreatment on the carcinostatic and toxic activities of some alkylating agents

1964 • 44 citations

Complete Inhibition of Mouse Leukaemia L1210 by 5(or 4)-[3,3-Mbis (2-Chloroethyl)-l-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196)

1966 • 42 citations

Triethylenethiophosphoramide (Thio-TEPA) in the treatment of neoplastic disease

1957 • 41 citations

Aryl-2-halogenoalkylamines

1968 • 38 citations

Reaction mechanism of some aromatic nitrogen mustards.

1967 • 37 citations

In-vitro-Thermosensibilisierung von Ehrlich-Mäuse-Ascites-Krebszellen durch Vitamin K₃ und K₅

1967 • 36 citations

The sensitivity of a yoshida sarcoma to methylene dimethane sulphonate

1969 • 35 citations

Quantitative Studies of the Effects of Nitrogen Mustard Analogs and Other Alkylating Agents on Ascites Tumors in Mice

1960 • 35 citations

Cyto-active amino-acids and peptides. Part II. Resolution of para-substituted phenylalanines and synthesis of p-di-(2-chloroethyl)amino-<scp>DL</scp>-phenyl[β-¹⁴C]alanine

1955 • 34 citations

Radiation and Radiomimetic Chemicals

1964 • 31 citations

TREATMENT OF MOLONEY LYMPHOMA WITH LETHAL DOSES OF DIMETHYL-MYLERAN COMBINED WITH INJECTIONS OF HÆMOPOIETIC CELLS

1969 • 28 citations

The formation of epoxides from cytotoxic polyol methanesulphonates under physiological conditions

1963 • 28 citations

‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents

1959 • 27 citations

Structure-Activity Relationship of Some Diamine Bis-epoxides in Mouse Leukaemia

1959 • 25 citations

Tumour-inhibiting Action of 1 : 6-Dimethanesulphonyl-D-mannitol

1958 • 25 citations

Synthesis, Chemistry, and Preliminary Pharmacology of Arsenical Nitrogen Mustards and Structurally Related Nonalkylating Arsenicals¹

1966 • 23 citations

460. Cytotoxic compounds. Part II. Some amides of the “nitrogen mustard” type

1961 • 22 citations

Potential Carcinolytic Agents.¹ IV. Diazoamino Mustards

1966 • 20 citations

Tumour Growth-inhibitory Alkyl Sulphonates

1956 • 20 citations

Aryl-2-halogenoalkylamines. Part XIII. Chloroethylamino-derivatives of some phenoxyalkanoic acids and of some substituted α-amino-acids

1955 • 19 citations

The reaction mechanisms, selectivity and specificity of action of 2-halogenoethylamines—An analysis

1964 • 19 citations

Patterns of response of animal tumors to anticancer agents. A systematic analysis of the literature in experimental cancer chemotherapy--1945-1958.

1963 • 17 citations

Potential anticancer agents. IV. Nitrogen mustards of methylbenzoic acids

1968 • 17 citations

The effect of glucose pretreatment on the anti-tumour action of Mannitol Myleran

1964 • 16 citations

Stereoisomere 1,4-Di-O-methansulfonyl-butan-1,2,3,4-tetrole

1961 • 16 citations

Heterocyclic Derivatives of 2-Chloroethyl Sulfide with Antitumor Activity¹

1966 • 16 citations

A Highly Reactive Sulfur Mustard Gas Derivative for Localized Infusion Studies

1965 • 14 citations

201. Some compounds related to the aromatic “nitrogen mustards.”

1950 • 14 citations

Enzyme Alterable Alkylating Agents. VI. Synthesis, Chemical Properties, Toxicities, and Clinical Trial of Haloacetates and Haloacetamides Containing Enzyme-Susceptible Bonds&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1963 • 13 citations

Potential Anticancer Agents.¹ LXXII. Alkylating Agents Derived from Indole. II.² Synthesis of a Nitrogen Mustard Derived from DL-Tryptophan

1962 • 13 citations

Nitrogen Mustards and Related Alkylating Agents

1963 • 13 citations

Potential Anticancer Agents.¹ LVII. Synthesis of Alkylating Agents Derived from 6-Amino-6-deoxy-D-glucose and 5-Amino-5-deoxy-D-ribose

1961 • 12 citations

CHEMOTHERAPY OF CANCER BY ETHYLENIMINO QUINONES: ITS FOUNDATIONS AND PROBLEMS

1958 • 11 citations

Haemotological and tumour-inhibitory effects of peptide derivatives of melphalan

1962 • 11 citations

ANTINEOPLASTIC AGENTS: X. N-BIS(2-FLUOROETHYL)AMINES

1964 • 11 citations

279. Interaction between carbonyl groups and biologically essential substituents. Part I. The effect of ketones on optically active amino-derivatives

1959 • 11 citations

Some Alkylating Derivatives of Nicotinic Acid. Synthesis and Antineoplastic Activities

1967 • 11 citations

Potential anticancer agents. V. Aromatic nitrogen mustards related to 3-[N,N-bis(2-chloroethyl)amino]-4-methylbenzoic acid

1969 • 11 citations

Dimethanesulphonic acid esters of sugar alcohols

1960 • 10 citations

Chemotherapeutic activity and pathological effects of an alkylating agent of short half‐life designed for intra‐arterial infusion (CB 1850)

1967 • 10 citations

Enzyme Alterable Alkylating Agents. V. Design of Sulfur Mustards With Varying Degrees of Hydrolytic Stability in a Search for Short Biological Half-Life Agents&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1963 • 8 citations

The clinical trial of an alkylating agent with a short half-life designed for intra-arterial chemotherapy

1971 • 8 citations

Potential Carcinolytic Agents.¹ III. Fluoronitrogen Mustard Analogs of Cyclophosphamide²

1966 • 8 citations

Cyto-active amino-acids and peptides. Part XIV. Poly- and copoly-(amino-acyl) derivatives of melphalan

1968 • 7 citations

Diazoacetic Esters of Hydroxyamino Acids¹

1959 • 6 citations

The toxicity and anti-tumour action of some alkylating sulphonamides

1963 • 6 citations

Attempts to use albumin as a carrier of l-phenylalanine mustard

1967 • 6 citations

N⁴-(2-Bromoethyl)-N⁴-ethylsulfanilamide, a Monofunctional Nitrogen Mustard with Antitumor Action¹

1965 • 5 citations

Synthesis of 6- and 7-Bis(2-chloroethyl)amino-DL-tryptophan^1a

1965 • 5 citations

N-Bis(β-Chloroethyl)amino Acids and Related Compounds as Tumor-Growth Retarding Agents

1955 • 5 citations

Potential carcinolytic agents. VI. New deactivated biological alkylating agents

1968 • 5 citations

Aryl-2-halogenoalkylamines. Part XV. Some cationic and basically substituted aryl compounds

1955 • 5 citations

The clinical use of an epoxide alkylating agent, epoxypropidine, in neoplastic disease

1960 • 5 citations

Studies on Carcinostatic Substances. XXX. Syntheses of Derivatives of Nitrogen Mustard related to Amino Acid.

1960 • 5 citations

Potential Anticancer Agents.¹ LXXIX. Aromatic Nitrogen Mustards Derived from Cysteine²

1963 • 4 citations

Evaluation of tryptophan mustard (NSC-62403) in patients with plasmacytic myeloma.

1967 • 4 citations

Aryl-2-halogenoalkylamines—XXII. Derivatives of phenoxyacetic acid: Synthesis and antineoplastic activities

1968 • 4 citations

Synthesis of Potential Antineoplastic Agents. XVII. N,N-Bis(2-fluoroethyl)anilines

1967 • 4 citations

Epodyl (AY 62013) in advanced cancer involving the brain and other organs

1967 • 3 citations

ANTITUMOUR ACTIVITY OF A SERIES OF ACETYLDIPEPTIDE ESTERS CONTAINING MELPHALAN

1966 • 3 citations

Tumour-inhibiting Action of 1,6-Di-(2-Bromoethylamino)-1,6-Dideoxy-D-Mannitol Dihydrobromide [DBM (R13)]

1959 • 3 citations

Cyto-active amino-acids and peptides. Part XII. Derivatives of serine and tyrosine and related hydroxy compounds

1967 • 3 citations

Phosphorus Mustards. II. The Synthesis and Biological Evaluation of Bis(2-chloroethyl)methylphosphine Hydrochloride¹

1966 • 3 citations

Synthesis of the Racemic and Optically Active Forms of α-Amino-γ-p-di(β-chloroethyl)aminophenylbutyric Acid¹

1958 • 2 citations

Phosphorus Mustards. I. A New Class of Potential Antineoplastic Agents¹

1964 • 2 citations

Synthesis of Potentially Cytoactive Amino Acid Amide Mustards^1a

1966 • 1 citations