The Biosynthesis of Unsaturated Fatty Acids

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

ON THE CALCULATION OF "TURNOVER TIME" AND "TURNOVER RATE" FROM EXPERIMENTS INVOLVING THE USE OF LABELING AGENTS

1943 • 538 citations

The Formation of Δ9-Unsaturated Fatty Acids

1960 • 503 citations

Metabolism and Physiological Significance of Lipids

1963 • 482 citations

Plant Lipid Biochemistry

1973 • 468 citations

THE EFFECT OF TEMPERATURE ON THE OIL CONTENT AND FATTY ACID COMPOSITION OF THE OILS FROM SEVERAL OIL SEED CROPS

1965 • 411 citations

Effect of Saturated and Unsaturated Fatty Acids on the Desaturation in Vitro of Palmitic, Stearic, Oleic, Linoleic, and Linolenic Acids

1966 • 406 citations

The Specificity of Triglyceride Synthesis from Diglycerides in Chicken Adipose Tissue

1961 • 402 citations

A Function of Cytochrome b5 in Fatty Acid Desaturation by Rat Liver Microsomes

1971 • 389 citations

Effect of Linolenic Acid Upon the Metabolism of Linoleic Acid

1963 • 309 citations

The enzymic chain elongation of fatty acids by rat-liver microsomes

1965 • 294 citations

Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes

1966 • 285 citations

The Chemical Constitution of Natural Fats

1941 • 252 citations

The desaturation step in the animal biosynthesis of polyunsaturated fatty acids

1971 • 228 citations

On the Origin of Unsaturated Fatty Acids in Clostridia

1961 • 225 citations

Partial purification of a lipoprotein with 5'-nucleotidase activity from membranes of rat liver cells.

1968 • 223 citations

The intracellular localization of an enzymatic defect of lipid metabolism in diabetic rats

1964 • 216 citations

The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver

1972 • 209 citations

A Review of Cyclopropenoid Compounds: Biological Effects of Some Derivatives

1965 • 204 citations

Long Chain Fatty Acid Activation in Subcellular Preparations from Rat Liver

1968 • 200 citations

Biosynthesis of Unsaturated Fatty Acids in Microorganisms

1964 • 196 citations

The Stereospecific Conversion of Stearic Acid to Oleic Acid

1965 • 189 citations

Biochemistry and methodology of lipids

1971 • 187 citations

Enzymic synthesis of monounsaturated fatty acids

1969 • 186 citations

Fat Metabolism in Higher Plants

1967 • 178 citations

Reconstitution of Hepatic Microsomal Stearoyl-Coenzyme A Desaturase System from Solubilized Components*

1972 • 173 citations

Fatty acid mutant of E. coli lacking a beta-hydroxydecanoyl thioester dehydrase.

1967 • 170 citations

Enzymatic Desaturation of Stearyl Acyl Carrier Protein

1968 • 165 citations

The preferred metabolic pathway from linoleic acid to arachidonic acid in vitro

1968 • 161 citations

A Requirement for Lipids by the Microsomal Stearyl Coenzyme A Desaturase

1969 • 158 citations

The effect of low temperatures on fatty acid biosynthesis in plants

1969 • 154 citations

The biosynthesis of long-chain fatty acids by lettuce chloroplast preparations

1963 • 151 citations

The conversion of stearic to oleic acid by liver and yeast preparations

1962 • 148 citations

Regulation of unsaturated fatty acids biosynthesis 1. Effect of unsaturated fatty acid of 18 carbons on the microsomal desaturation of linoleic acid into γ-linolenic acid

1969 • 147 citations

The Mechanism of Formation of Polyunsaturated Fatty Acids by Photosynthetic Tissue

1969 • 147 citations

Synthesis of fatty acyl CoA and other thiol esters using N-hydroxysuccinimide esters of fatty acids

1969 • 146 citations

The Synthesis of Phosphoglycerides and Some Biochemical Applications

1964 • 146 citations

Differential responses to fasting and subsequent feeding by microsomal systems of rat liver: 6- and 9-desaturation of fatty acids

1969 • 141 citations

Stearyl CoA as a precursor of oleic acid and glycerolipids in mammary microsomes from lactating bovine: Possible regulatory step in milk triglyceride synthesis

1972 • 136 citations

Fatty-Acid Composition of Candida utilis as Affected by Growth Temperature and Dissolved-Oxygen Tension

1969 • 134 citations

Inhibition of Fatty Acyl Desaturase by Cyclopropene Fatty Acids

1967 • 126 citations

Depression of microsomal desaturation of linoleictoy-linolenicacid in the alloxan-diabetic rat

1966 • 123 citations

Stimulation by Phenols of the Reoxidation Microsomal Bound Cytochrome b5 and Its Implication to Fatty Acid Desaturation

1971 • 122 citations

Die enzymatische Dehydrierung der Stearinsäure zu Ölsäure

1959 • 120 citations

Turnover of the glycerolipids of pumpkin leaves. The importance of phosphatidylcholine

1970 • 116 citations

A FATTY ACID SYNTHETASE FROM E. COLI

1962 • 116 citations

β-Hydroxydecanoyl Thioester Dehydrase

1967 • 116 citations

The role of oxygen in the biosynthesis of unsaturted fatty acids

1958 • 116 citations

Chain Elongation of Linoleic Acid and Its Inhibition by Other Fatty Acids in Vitro

1967 • 115 citations

Factors Involved in Fatty Acyl CoA Desaturation by Fungal Microsomes. The Relative Roles of Acyl CoA and Phospholipids as Substrates

1971 • 115 citations

Requirement for Reduced Diphosphopyridine Nucleotide-Cytochrome b5 Reductase in Stearyl Coenzyme A Desaturation

1970 • 114 citations

Linoleic , α-linolenic acid biosynthesis in plant leaves and a green alga

1965 • 112 citations

Lipid Metabolism in the Bacteria

1966 • 112 citations

The occurrence of unusual fatty acids in faecal lipids from human beings with normal and abnormal fat absorption

1961 • 111 citations

The fatty acids of Euglena gracilis

1964 • 110 citations

β-Hydroxydecanoyl Thioester Dehydrase

1967 • 109 citations

Effect of low temperature on fatty acid biosynthesis in seeds

1969 • 104 citations

Enzymatic Desaturation of Stearyl Acyl Carrier Protein

1966 • 103 citations

β-Hydroxydecanoyl Thioester Dehydrase

1969 • 103 citations

Cofactor Requirements for the Formation of Δ9-Unsaturated Fatty Acids in Mycobacterium phlei

1964 • 101 citations

β-Hydroxydecanoyl Thioester Dehydrase

1968 • 101 citations

Mode of Inhibition of β-Hydroxydecanoyl Thioester Dehydrase by 3-Decynoyl-N-acetylcysteamine

1970 • 99 citations

A Comparison of Lipid Patterns in Photosynthesizing and Nonphotosynthesizing Cells of Euglena Gracilis^*

1963 • 98 citations

DEUTERIUM AS AN INDICATOR IN THE STUDY OF INTERMEDIARY METABOLISM

1936 • 97 citations

Fat Metabolism in Higher Plants

1971 • 97 citations

Requirement for three protein components in microsomal stearyl coenzyme A desaturation

1971 • 96 citations

Metabolism of Fatty Acids

1969 • 95 citations

The biosynthesis of long-chain saturated and unsaturated fatty acids in isolated plant leaves

1963 • 94 citations

On the biosynthesis of dienoic fatty acid by animal tissues

1963 • 92 citations

Mechanisms and stereochemistry in fatty acid metabolism

1970 • 90 citations

Interrelationships between fatty acid biosynthesis and acyl-lipid synthesis in Chlorella vulgaris

1967 • 90 citations

A Novel Mechanism for the Biosynthesis of Unsaturated Fatty Acids

1961 • 89 citations

THE CONVERSION OF PALMITIC ACID INTO STEARIC AND PALMITOLEIC ACIDS IN RATS

1940 • 86 citations

Fat metabolism in higher plants

1971 • 85 citations

The fatty acid metabolism of Chlorella vulgaris

1965 • 83 citations

The Metabolism of Hydroxystearic Acids in Yeast

1962 • 82 citations

Desaturation of Oleyl Phospholipid to Linoleyl Phospholipid in Torulopsis utilis

1973 • 80 citations

The Antibacterial Activity of 3-Decynoyl-N-acetylcysteamine

1968 • 80 citations

Specificity of the fatty acid desaturases

1971 • 78 citations

The Biosynthesis of Δ9- and Δ5-Monosaturated Fatty Acids by Bacteria

1964 • 77 citations

On the enzymatic synthesis of unsaturated fatty acids in Escherichia coli.

1967 • 75 citations

Biosynthesis of polyenoic fatty acids

1961 • 75 citations

The stereochemistry of desaturations of long-chain fatty acids in Chlorella vulgaris

1968 • 73 citations

Inhibition by cyclopropene fatty acids of the desaturation of stearic acid in hen liver

1967 • 73 citations

Effect of diet on linoleic acid desaturation and on some enzymes of carbohydrate metabolism

1970 • 71 citations

Effect of insulin on the oxidative desaturation ofa‐linolenic, oleic and palmitic acids

1967 • 70 citations

The Biosynthesis of Unsaturated Fatty Acids by Bacilli

1970 • 69 citations

The desaturase activity of goat and sow mammary tissue

1970 • 67 citations

Effect of temperature on the enzymatic synthesis of unsaturated fatty acids in Torulopsis utillis

1963 • 66 citations

Fatty acid biosynthesis and the role of the acyl carrier protein.

1967 • 65 citations

Positional distribution of fatty acids in monogalactosyl diglyceride fractions from leaves and algae Structural and metabolic studies

1970 • 64 citations

Synthesis of Oleic Acid by Euglena gracilis

1965 • 64 citations

Desaturation of saturated fatty acids by rat liver microsomes

1970 • 64 citations

Enzymatic Studies on the Mechanism of the Retroconversion of C₂₂-Polyenoic Fatty Acids to their C₂₀-Homologues

1970 • 64 citations

Conversion in vitro of linoleic acid into γ-linolenic acid by rat-liver enzymes

1962 • 63 citations

Isolation of an Acyl Carrier Protein Component from the Multienzyme Complex of Yeast Fatty Acid Synthetase

1969 • 63 citations

Fat metabolism in higher plants

1972 • 62 citations

Fatty acid desaturase systems of hen liver and their inhibition by cyclopropene fatty acids

1969 • 60 citations

Fat Metabolism in Higher Plants

1972 • 59 citations

Influence of temperature on the composition of fatty acids and on lipogenesis in frog tissues

1969 • 56 citations

Inhibitory effect of docosa-4,7,10,13,16,19-hexaenoicacid upon the oxidative desaturation of linoleic into γ-linolenic acid and of α-linolenic into octadeca-6,9,12,15-tetraenoic acid

1967 • 56 citations

Determination of acyl-thiolesters by gas-liquid chromatography of their sodium borohydride reduction products

1968 • 55 citations

Fatty Acid Synthetase and β-Hydroxydecanoyl Coenzyme A Dehydrase from Escherichia coli

1964 • 55 citations

Studies on the Lipogenesis in Animal Tissues under Pathological Conditions

1961 • 54 citations

Effect of Free Unsaturated Fatty Acids on Fatty Acid Desaturation by Liver Preparations*

1967 • 54 citations

The effect of intravenous infusions of sterculic acid on milk fat synthesis

1972 • 53 citations

The separation, structure and metabolism of monogalactosyl diglyceride species inChlorella vulgaris

1969 • 52 citations

Metabolism of Essential Fatty Acids

1960 • 51 citations

Mechanism of Action of β-Hydroxydecanoyl Thioester Dehydrase

1968 • 50 citations

Inhibition of the Desaturation of Stearic to Oleic Acid by Cyclopropene Fatty Acids

1967 • 49 citations

Assay and Isolation of a Cyanide-binding Protein of Rat Liver Microsomes

1970 • 49 citations

Fatty Acid Biosynthesis and the Role of the Acyl Carrier Protein1 1This investigation was supported in part by grants from the United States Public Health Service, AM-10550, HE-10406, the National Science Foundation, GB-5056X, GB-5142X, and the American Cancer Society PRA-33.

1967 • 49 citations

Chain Elongation of α- and γ-Linolenic Acids and the Effect of Other Fatty Acids on Their Conversion in Vitro

1968 • 48 citations

Lipid Biochemistry: An introduction

1972 • 47 citations

Fatty acid metabolism in the chloroplast lipids of green and blue‐green algae

1968 • 47 citations

Synthesis of long-chain fatty acids in mitochondria

1969 • 46 citations

The biosynthesis of polyunsaturated fatty acids in plants

1971 • 46 citations

A soluble fatty acid synthesizing system from lettuce chloroplasts

1965 • 45 citations

The Inhibition of Unsaturated Fatty Acid Biosynthesis in Plants by Sterculic Acid

1968 • 44 citations

The sequence of formation of fatty acids in developing soybean seeds

1954 • 44 citations

Comparative aspects of unsaturated fatty acid synthesis

1964 • 44 citations

Competitive effect of alpha- and gamma-lionlenyl-CoA in linoleyl-CoA desaturation to gamma-linolenyl-CoA.

1969 • 44 citations

The mechanism of ricinoleic acid biosynthesis in Ricinuscommunis seeds

1967 • 43 citations

Ring position in cyclopropene fatty acids and stearic acid desaturation in hen liver

1972 • 43 citations

Sterculic derivatives and pink egg formation

1962 • 42 citations

The Influence of Chronic Vitamin C Deficiency on Fatty Acid Composition of Blood Serum, Liver Triglycerides and Cholesterol Esters in Guinea Pigs

1969 • 42 citations

Competitive effect of α- and γ-linolenyl-CoA and arachidonyl-CoA in linoleyl-CoA desaturation to γ-linolenyl-CoA

1969 • 41 citations

Inhibition of the Stearyl Coenzyme A Desaturase System by Sterculate

1970 • 40 citations

The specificity of fatty acid desaturases and hydroxylases

1972 • 40 citations

Oleic acid synthesis by a particulate preparation from developing castor oil seeds

1969 • 40 citations

Synthesis of linoleic acid by particulate system from safflower seeds

1964 • 40 citations

The effect of insulin on monounsaturated fatty acid synthesis in diabetic rats. The stability of the informational RNA and of the enzyme system concerned with fatty acid desaturation

1966 • 40 citations

A β-hydroxydecanoyl-ACP dehydrase specific for saturated fatty acid biosynthesis in E.,coli

1967 • 39 citations

Effect of arachidonic acid on the microsomal desaturation of linoleic into γ-linolenic acid and their simultaneous incorporation into the phospholipids

1968 • 39 citations

Biosynthesis of Unsaturated Fatty Acids in Acanthamoeba Sp

1964 • 38 citations

The involvement of lecithin and monogalactosyl diglyceride in linoleate synthesis by green and blue-green algae

1971 • 38 citations

The dynamic behavior during dietary induction of the terminal enzyme (cyanide-sensitive factor) of the stearyl CoA desaturation system of rat liver microsomes

1972 • 38 citations

Intracellular distribution of palmitoyl-CoA synthetase in rat liver

1970 • 35 citations

Sites of binding of acetate, malonate and acetoacetate to the pigeon liver fatty acid synthetase

1968 • 35 citations

A Hydroxy Fatty Acid Dehydrogenase in Euglena gracilis

1966 • 34 citations

Elongation of Acyl Carrier Protein Derivatives by Bacterial and Plant Extracts

1967 • 34 citations

Fat Metabolism in Plants

1967 • 34 citations

The Biosynthesis of Unsaturated Fatty Acids by Bacilli

1972 • 33 citations

Metabolism of some monohydroxystearic acids in the intact rat

1964 • 33 citations

Effect of polyunsaturated fatty acids on the desaturation in vitro of linoleic to γ-linolenic acid

1965 • 32 citations

Some properties of microsomal fatty acid activating enzyme of rat liver

1972 • 32 citations

Preliminary Partial Purification of Hen Liver Microsomal Stearoyl‐CoA Desaturase

1970 • 31 citations

Hydroxystearic Acids and the Biosynthesis of Unsaturated Fatty Acids

1960 • 30 citations

Reciprocal interactions in the desaturation of linoleic acid into γ‐linolenic and eicosa‐8,11,14‐trienoic into arachidonic

1969 • 30 citations

The effects of thyroxine on the pattern of fatty acid synthesis in rat liver

1966 • 30 citations

The influence of chain length on the dehydrogenation of saturated fatty acids

1968 • 30 citations

A new assay for fatty acid desaturation

1969 • 30 citations

A study of some of the factors involved in regulating the conversion of octadeca-8,11-dienoate to eicosa-4,7,10,13-tetraenoate in the rat

1971 • 30 citations

The Metabolism of Polyenoic Fatty Acids

1965 • 28 citations

Presence d'acides polyinsatures dans une bacterie: isolement, a partir des lipides de Mycobacterium phlei, d'acide hexatriacontapentaene-4,8,12,16,20oique et d'acides analogues

1969 • 28 citations

Inhibition of Stearoyl Coenzyme A Desaturase by Sterculate in Mouse Liver Microsomes

1972 • 27 citations

Cofactor requirements for fatty acid desaturation in Mycobacterium phlei

1962 • 27 citations

On the Mechanism of the Enzymatic Synthesis of Unsaturated Fatty Acids in Escherichia coli

1963 • 26 citations

The substrate specificity of desaturases: The conversion of cis-12-octadecenoic acid into linoleic acid in different animal and plant species

1972 • 26 citations

Comparative effects of docosa‐4,7,10,13,16‐pentaenoic acid and docosa‐4,7,10,13,16,19‐hexaenoic acid on the desaturation of linoleic acid and α‐linolenic acid

1970 • 25 citations

Desaturation of palmitate and stearate by cell‐free fractions from soybean cotyledons

1969 • 25 citations

Evidence for Separate Pathways for the Biosynthesis of Saturated and Unsaturated Fatty Acids by an Avocado Enzyme System

1962 • 25 citations

Alternate route for the biosynthesis of oleic acid in the rat

1969 • 24 citations

Light-stimulated enzymic synthesis of oleic and palmitic acids by lettuce-chloroplast preparations

1962 • 24 citations

Studies on the Mechanism of Fatty Acid Synthesis

1968 • 23 citations

Isotope effects in the desaturation of stearic to oleic acid

1971 • 23 citations

Conversion of C17 polyenoic acids into more highly unsaturated acids by the rat

1964 • 22 citations

THE BIOSYNTHESIS OF LONG-CHAIN FATTY ACIDS IN THE DEVELOPING CASTOR BEAN

1965 • 22 citations

Bacterial biosynthesis of polyunsaturated fatty acids

1969 • 22 citations

Fatty Acids in the Pellicles and Plastids of Light-grown and Dark-grown Cells of Euglena gracilis^*

1965 • 21 citations

Intermediate- and long-chain β-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase

1968 • 21 citations

The quantitative dependence of glucose‐6‐phosphohydrolase upon phospholipids: Effects of phospholipase C at 50° and 370°

1970 • 18 citations

Der Stoffwechsel der ungesättigten Fettsäuren, VII. Untersuchungen über die Bildung dercis-olefinischen Bindungen in Polyenfettsäuren

1966 • 16 citations

Untersuchungen zur Biosynthese ungesattigter Fettsauren in Hefe

1971 • 16 citations

An in vitro study of the effects of dietary alteration and fasting on the desaturation of palmitic, stearic eicosa-8,11-dienoic and eicosa-8,11,14-trienoic acids

1971 • 16 citations

“Solubilization” of the stearoyl‐CoA desaturase of rat liver microsomes

1968 • 15 citations

Evidence for induction of a palmitate- and stearate-independent system of monoenoic fatty acid synthesis in chicks

1967 • 15 citations

Lack of correlation between cyanide-binding spectrum and fatty acid desaturase activity in liver microsomes

1971 • 13 citations

INCORPORATION OF ACETATE-1-C¹⁴ INTO THE LONG-CHAIN FATTY ACIDS OF SOME OIL SEED CROPS

1965 • 12 citations

Fat metabolism in higher plants. β-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp

1972 • 11 citations

The metabolism of 9(10)-hydroxystearic acid by the cellular slime mold, Dictyostelim discoideum

1964 • 10 citations

Biosynthesis of Δ9 monounsaturated fatty acids in slices of the ice-plant, Carpobrotus chilense

1965 • 7 citations

The Effect of Chain Length of Substrate on the Formation of Mono-unsaturated Fatty Acids in Rat Liver Preparation

1969 • 6 citations

Chain length specificity of the saturated fatty acyl desaturase in rat liver preparations

1970 • 6 citations

Higher Fatty Acids Dehydrogenase in Plant Seeds

1957 • 5 citations

Tritium release assay for oleic acid desaturation

1972 • 4 citations

Higher Fatty Acids Dehydrogenase in Plant Seeds

1957 • 2 citations