Isolated Nerve Terminals as an In Vitro Preparation for the Study of Dynamic Aspects of Transmitter Metabolism and Release

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

CHOLINERGIC AND NON‐CHOLINERGIC NERVE ENDINGS IN RAT BRAIN–I

1962 • 784 citations

The isolation and characterization of acetylcholine-containing particles from brain

1959 • 570 citations

The application of subcellular fractionation techniques to the study of brain function

1965 • 466 citations

Methods of Neurochemistry

1973 • 454 citations

The small pyramidal neuron of the rat cerebral cortex

1969 • 427 citations

ELECTRICAL ACTIVITIES IN THIN SECTIONS FROM THE MAMMALIAN BRAIN MAINTAINED IN CHEMICALLY‐DEFINED MEDIA IN VITRO

1966 • 395 citations

Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography

1972 • 371 citations

EXTRACELLULAR SPACE AS A PATHWAY FOR EXCHANGE BETWEEN BLOOD AND NEURONS IN THE CENTRAL NERVOUS SYSTEM OF THE LEECH: IONIC COMPOSITION OF GLIAL CELLS AND NEURONS

1964 • 325 citations

Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.

1971 • 283 citations

Glutamate and γ-Aminobutyric Acid in Brain

1970 • 269 citations

AMINO ACIDS AS CENTRAL NERVOUS TRANSMITTERS: THE INFLUENCE OF IONS, AMINO ACID ANALOGUES, AND ONTOGENY ON TRANSPORT SYSTEMS for <scp>l</scp>‐GLUTAMIC AND <scp>l</scp>‐ASPARTIC ACIDS AND GLYCINE INTO CENTRAL NERVOUS SYNAPTOSOMES OF THE RAT¹

1973 • 261 citations

INTRACELLULAR AND EXTRACELLULAR RESPONSES OF THE SEVERAL REGIONS OF THE MAUTHNER CELL OF THE GOLDFISH

1962 • 251 citations

Autoradiographic localisation of [3H]GABA and [3H]glutamate over satellite glial cells

1974 • 230 citations

METABOLISM OF BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES: RESPONSE TO DEPOLARIZING INFLUENCES

1972 • 215 citations

The Synaptosome

1969 • 197 citations

Rate of release of amino acids from the cerebral cortex in the cat as affected by brainstem and thalamic stimulation

1969 • 194 citations

Tetanus toxin and spinal inhibition

1968 • 191 citations

THE MOLECULAR ORGANIZATION OF BIOLOGICAL MEMBRANES

1971 • 189 citations

Distribution of sodium-plus-potassium-stimulated adenosine-triphosphatase activity in isolated nerve-ending particles

1965 • 189 citations

Calcium-Dependent Norepinephrine Release from Presynaptic Nerve Endings In Vitro

1972 • 187 citations

The ‘compartmentation’ of choline acetyltransferase within the synaptosome

1967 • 182 citations

RESPIRATION IN VITRO OF SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 181 citations

Subcellular distribution of taurine and cysteinesulphinate decarboxylase in developing rat brain

1971 • 179 citations

UPTAKE AND RELEASE OF TAURINE FROM RAT BRAIN SLICES

1972 • 168 citations

γ-Aminobutyric Acid Uptake by Sympathetic Ganglia

1972 • 162 citations

Role of sodium, potassium, quabain and reserpine in uptake, storage and metabolism of biogenic amines in synaptosomes

1968 • 159 citations

LES COMPARTIMENTS D'ACETYLCHOLINE DE L'ORGANE ELECTRIQUE DE LA TORPILLE ET LEURS MODIFICATIONS PAR LA STIMULATION

1972 • 156 citations

SUBCELLULAR DISTRIBUTION OF ENDOGENOUS AND [³H] γ‐AMINOBUTYRIC ACID IN RAT CEREBRAL CORTEX

1969 • 154 citations

UPTAKE AND RELEASE OF [¹⁴C]ADENINE DERIVATIVES AT BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES IN A SUPERFUSION SYSTEM

1974 • 153 citations

The source of choline for acetylcholine synthesis in a sympathetic ganglion

1969 • 148 citations

SYNTHESIS AND RELEASE OF [¹⁴C]ACETYLCH0LINE IN SYNAPTOSOMES

1971 • 148 citations

AMINO ACIDS IN SYNAPTIC VESICLES FROM MAMMALIAN CEREBRAL CORTEX: A REAPPRAISAL

1973 • 142 citations

METABOLISM OF GLUCOSE AND GLUTAMATE BY SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 142 citations

DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES

1973 • 141 citations

Tetanus toxin and the synaptic release of GABA

1973 • 136 citations

Metabolic response of synaptosomes to electrical stimulation: Release of amino acids

1970 • 131 citations

Electrical activity observed in guinea‐pig olfactory cortex maintained in vitro

1968 • 122 citations

Membrane potentials in mammalian cerebral tissues in vitro: dependence on ionic environment

1961 • 122 citations

Modulation of corticotrophin-releasing factor release from hypothalamic synaptosomes

1974 • 118 citations

A Unique Synaptosomal Fraction, Which Accumulates Glutamic and Aspartic Acids, in Brain Tissue

1971 • 117 citations

Kinetics of serotonin accumulation into synaptosomes of rat brain-effects of amphetamine and chloroamphetamines

1973 • 117 citations

CHARACTERISTICS OF FAST FEEDBACK CONTROL OF CORTICOTROPHIN RELEASE BY CORTICOSTEROIDS

1972 • 115 citations

PATTERNS OF AMINO ACID RELEASE FROM NERVE-ENDINGS ISOLATED FROM SPINAL CORD AND MEDULLA

1973 • 114 citations

CEREBRAL AMINO ACID TRANSPORT IN VITRO—I SOME REQUIREMENTS AND PROPERTIES OF UPTAKE

1964 • 107 citations

Stimulus-Coupled Secretion of γ-Aminobutyric Acid from Rat Brain Synaptosomes

1973 • 103 citations

Exchangeability of radioactive acetylcholine with the bound acetylcholine of synaptosomes and synaptic vesicles

1968 • 101 citations

Synaptosomes: Different Populations storing Catecholamines and Gamma-aminobutyric Acid in Homogenates of Rat Brain

1968 • 94 citations

SYNTHESIS OF RADIOACTIVE ACETYLCHOLINE FROM [³H]CHOLINE AND ITS RELEASE FROM CEREBRAL CORTEX SLICES IN VITRO

1971 • 92 citations

Regional studies of catecholamines in the rat brain—III:

1966 • 92 citations

EFFECT OF VINBLASTINE AND COLCHICINE ON UPTAKE AND RELEASE OF PUTATIVE TRANSMITTERS BY SYNAPTOSOMES AND ON BRAIN ACTOMYOSIN‐LIKE PROTEIN

1973 • 90 citations

IONIC BASIS FOR THE DEPOLARIZATION OF CEREBRAL TISSUES BY EXCITATORY ACIDIC AMINO ACIDS

1966 • 89 citations

Application of cytochemical techniques to the study of suspected transmitter substances in the nervous system.

1972 • 88 citations

CATION MODULATION OF SYNAPTOSOMAL RESPIRATION

1972 • 87 citations

Subcellular fractionation of rat cerebellum: An electron microscopic and biochemical investigation. III. Isolation of large fragments of the cerebellar glomeruli

1975 • 84 citations

Univalent cations and the respiration of brain-cortex slices

1962 • 82 citations

Preferential release of newly synthesized ³H‐acetylcholine from rat cerebral cortex slices in vitro

1973 • 82 citations

Synaptic vesicles from the rat hypothalmus. Isolation and norepinephrine content

1965 • 78 citations

Electric Response of Glia Cells in Cat Brain

1958 • 76 citations

The stimulus‐induced release of acetylcholine from synaptosome beds and its calcium dependence

1972 • 73 citations

Photodetachment of Electrons from Major Negative Ions in the Lower D Region

1972 • 71 citations

Tetanus Toxin inhibits Amino Acid Release from Nerve Endings in vitro

1973 • 71 citations

AMINO ACIDS AS PUTATIVE TRANSMITTERS: FAILURE TO BIND TO SYNAPTIC VESICLES OF GUINEA PIG CEREBRAL CORTEX¹

1972 • 69 citations

Hyperlipoproteinemia in alcoholic subjects

1973 • 62 citations

The subcellular distribution of [N-Me−3H]-acetylcholine synthesized by brain in vivo

1969 • 61 citations

The heterogeneity of bound acetylcholine and synaptic vesicles

1972 • 61 citations

Formation of Catechol Compounds from Phenylalanine and Tyrosine with Isolated Nerve Endings

1972 • 60 citations

An in vitro model for the study of psychotropic drugs and as a criterion of antidepressant activity

1973 • 60 citations

STUDIES ON SODIUM TRANSPORT IN RAT BRAIN NERVE‐ENDING PARTICLES

1968 • 59 citations

Subcellular fractionation of rat cerebellum: an electron microscopic and biochemical investigation. I. preservation of large fragments of the cerebellar glomeruli

1974 • 58 citations

Synthesis and release of (14C) acetylcholine in synaptosomes

1970 • 58 citations

ISOLATION OF [³H]ACETYLCHOLINE POOLS BY SUBCELLULAR FRACTIONATION OF CEREBRAL CORTEX SLICES INCUBATED WITH [³H]CHOLINE

1971 • 58 citations

The yield of synaptosomes from the cerebral cortex of guinea pigs estimated by a polystyrene bead ?tagging? procedure

1966 • 56 citations

The storage and release of acetylcholine by cholinergic nerve terminals: recent results with non-mammalian preparations.

1972 • 55 citations

SYNTHESIS OF ACETYLCHOLINE IN DIFFERENT COMPARTMENTS OF BRAIN NERVE TERMINALS IN VIVO AS STUDIED BY THE INCORPORATION OF CHOLINE FROM PLASMA AND THE EFFECT OF PENTOBARBITAL ON THIS PROCESS

1973 • 54 citations

UPTAKE AND RELEASE OF NOREPINEPHRINE BY RAT BRAIN TISSUE FRACTIONS PREPARED BY ULTRAFILTRATION ¹

1971 • 51 citations

THE SUBCELLULAR LOCALIZATION OF DOPAMINE AND ACETYLCHOLINE IN THE DOG CAUDATE NUCLEUS

1963 • 50 citations

Specific Glycine-Accumulating Synaptosomes in the Spinal Cord of Rats

1972 • 46 citations

INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY¹

1974 • 46 citations

A LIGHT‐SCATTERING TECHNIQUE FOR THE STUDY OF THE PERMEABILITY OF RAT BRAIN SYNAPTOSOMES IN VITRO

1970 • 45 citations

ASSOCIATION OF TYROSINE HYDROXYLASE WITH SYNAPTIC VESICLES IN BOVINE CAUDATE NUCLEUS¹

1969 • 45 citations

An autoradiographic study of uptake of exogenous glycine by vertebrate spinal cord splicesin vitro

1972 • 45 citations

Perceptual Structure of the Necker Cube

1973 • 44 citations

SUBCELLULAR FRACTIONATION OF POSTMORTEM BRAIN¹

1973 • 42 citations

TETANUS TOXIN AND AMINO ACID LEVELS IN CAT SPINAL CORD

1969 • 39 citations

CHARACTERISTICS REQUIRED IN ELECTRICAL PULSES OF RECTANGULAR TIME‐VOLTAGE RELATIONSHIPS FOR METABOLIC CHANGE AND ION MOVEMENTS IN MAMMALIAN CEREBRAL TISSUES

1963 • 39 citations

The effect of homogenization conditions on sub-cellular distribution in brain

1965 • 39 citations

ISOLATION OF SYNAPTIC COMPLEXES IN A CAESIUM CHLORIDE DENSITY GRADIENT: ELECTRON MICROSCOPIC AND IMMUNOHISTOCHEMICAL STUDIES

1969 • 37 citations

The Nature of the Acetylcholine Pools in Brain Tissue

1969 • 37 citations

Properties of the Isolated Nerve Endings

1972 • 37 citations

Effects of reserpine and tyramine on release of norepinephrine from synaptosomes

1972 • 37 citations

Subcellular fractionation of rat cerebellum: an electron microscopic and biochemical investigation. II. Resolution of morphologically characterised fractions

1974 • 37 citations

Chemical and Metabolic Characteristics of Synaptic Complexes from Brain Isolated by Zonal Centrifugation in a Cesium Chloride Gradient

1971 • 36 citations

A STUDY OF THE METABOLISM AND RELEASE OF DOPAMINE AND AMINO ACIDS FROM NERVE ENDINGS ISOLATED FROM SHEEP CORPUS STRIATUM

1976 • 36 citations

Techniques in tissue metabolism. 4. Apparatus for maintaining and rapidly transferring tissue sections

1956 • 35 citations

The storage of norepinephrine and some of its derivatives in brain synaptosomes

1965 • 35 citations

Membrane potentials in isolated neurones in vitro from Deiters' nucleus of rabbit

1965 • 35 citations

Biological Sciences: Release of Amino-acids and Neurosecretory Substances after Stimulation of Nerve-endings (Synaptosomes) isolated from the Hypothalamus

1972 • 33 citations

High Affinity Transport of 2-Deoxyglucose in Isolated Synaptic Nerve Endings

1973 • 33 citations

An electron-microscope study of subcellular fractions of Octopus brain

1967 • 32 citations

Separation of catecholamine-storing synaptosomes in different regions of rat brain.

1969 • 32 citations

Observations on the morphology of mammalian synaptosomes following their incubation and electrical stimulation

1971 • 31 citations

Biochemical and morphological studies of the short and long term survival of isolated nerve-endings

1975 • 30 citations

Release of amino acids from the chronically‐superfused mammalian cerebral cortex

1974 • 30 citations

Isolation and characterization of membranes from rat cerebral cortex

1970 • 30 citations

A morphological and biochemical study of subcellular fractions of the guinea pig spinal cord

1971 • 30 citations

Electrical Responses in Brain Samples

1967 • 29 citations

Studies on the Subcellular Localization of Corticotrophin Releasing Factor (CRF) and Vasopressin in the Median Eminence of the Rat¹

1970 • 29 citations

Accumulation of 3H-glycine in interneurons of the cat spinal cord

1972 • 27 citations

THE INFLUENCE OF SODIUM, POTASSIUM AND LANTHANUM ON AMINO ACID RELEASE FROM SPINAL–MEDULLARY SYNAPTOSOMES

1975 • 26 citations

Neurotransmitter-Specific Synaptosomes in Rat Corpus Striatum: Morphological Variations ^*

1971 • 25 citations

The identification of fractions enriched in nonmyelinated axons from rat whole brain

1970 • 25 citations

RELEASE OF CORTICOTROPHIN RELEASING FACTOR AND OTHER HYPOPHYSIOTROPIC SUBSTANCES FROM ISOLATED NERVE-ENDINGS (SYNAPTOSOMES)

1975 • 24 citations

Effects of inhibitors of (Na plus, plus, K plus)-dependent adenosine triphosphatase on the uptake of norepinephrne by synaptosomes.

1971 • 24 citations

BIOCHEMICAL ORGANIZATION OF CHOLINERGIC NERVE TERMINALS IN THE CEREBRAL CORTEX

1969 • 23 citations

Studies of the respiration of synaptosomes

1971 • 22 citations

Subcellular distribution of endogenous and [3H]-GABA in rat cerebral cortex.

1969 • 21 citations

CONTROL OF AEROBIC GLYCOLYSIS IN GUINEA‐PIG CEREBRAL CORTEX SLICES

1972 • 21 citations

Resealing Properties of Biological Membranes

1973 • 17 citations

Calcium-dependent release of [14C]GABA from vinblastine and colchicine treated synaptosomes

1974 • 16 citations

Biochemical studies of isolated nerve endings and other particulates of bullfrog brain

1967 • 16 citations

Cellular Organelles and Membranes in Mental Retardation

1972 • 14 citations

FLUID SPACES OF SYNAPTOSOME BEDS

1974 • 11 citations

Isolation and ultrastructure of human synaptic complexes

1973 • 10 citations

Isolation of a fraction from rat cerebellum enriched in nerve terminals of one single type (mossy-fibre terminals)

1972 • 8 citations

Development of Glucose Oxidation in Isolated Nerve Endings

1973 • 7 citations

Proceedings: Calcium dependent release of hypophysiotropic substances from nerve-endings (synaptosomes) isolated from the hypothalamus.

1973 • 7 citations

Responses of synaptosomes to electrical stimulation

1970 • 7 citations

The Effect of Stimulation on 32P Incorporation in vitro into the Phospholipids of Subsynaptosomal Fractions

1974 • 6 citations

METABOLISM OF NERVE-ENDING PARTICLES

1969 • 4 citations

The Release of Endogenous 3,4-Dihydroxyphenethylamine from Synaptosomes Isolated from Corpus Striatum

1975 • 4 citations

Release of corticotrophin-releasing factor (CRF) following the electrical stimulation of nerve-endings isolated from the sheep hypothalamus.

1972 • 2 citations