An in vitro model for the study of psychotropic drugs and as a criterion of antidepressant activity

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

INTENSIFICATION OF THE CENTRAL SEROTONINERGIC PROCESSES AS A POSSIBLE DETERMINANT OF THE THYMOLEPTIC EFFECT

1969 • 705 citations

Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramine

1969 • 645 citations

Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.

1970 • 518 citations

Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas.

1969 • 445 citations

Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates.

1969 • 420 citations

Handbook of experimental pharmacology

1973 • 345 citations

Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue

1969 • 321 citations

The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons

1971 • 220 citations

LACTATE DEHYDROGENASE AS A CYTOPLASMIC MARKER IN BRAIN

1963 • 202 citations

Localization of tritiated serotonin in rat brain by electron-microscopic autoradiography.

1967 • 179 citations

The uptake of labeled norepinephrine by isolated brain and other tissues of the cat

1962 • 178 citations

Effect of Lithium on the Uptake of Noradrenaline by Synaptosomes

1967 • 171 citations

Role of sodium, potassium, quabain and reserpine in uptake, storage and metabolism of biogenic amines in synaptosomes

1968 • 159 citations

5-hydroxytryptamine uptake by rat brain

1967 • 147 citations

Structural specificity for inhibition of [14C]-5-hydroxytryptamine uptake by cerebral slices

1970 • 139 citations

THE PRESENT STATUS OF PSYCHOTROPIC DRUGS

1966 • 137 citations

A “Proportion Graph” Method for Measuring Binding Systems

1970 • 135 citations

The inhibition of human platelet 5-hydroxytryptamine uptake by tricyclic antidepressive drugs. The relation between structure and potency

1969 • 116 citations

Quantitative studies of norepinephrine uptake by synaptosomes

1968 • 110 citations

INFLUENCE OF IMIPRAMINE AND RELATED PSYCHOACTIVE AGENTS ON THE EFFECT OF 5-HYDROXYTRYPTAMINE AND CATECHOLAMINES ON THE CAT NICTITATING MEMBRANE.

1963 • 104 citations

A kinetic analysis of drugs that inhibit the adrenergic neuronal membrane amine pump

1967 • 82 citations

Mechanism of transport and storage of biogenic amines. III. Effects of sodium and potassium on kinetics of 5-hydroxytryptamine and norepinephrine transport by rabbit synaptosomes

1970 • 77 citations

Studies in vitro of amine uptake mechanisms in heart

1966 • 75 citations

A study of the transport of 5-hydroxytryptophan and 5-hydroxytryptamine (serotonin) into brain.

1963 • 68 citations

Progesterone-estrogen effects on uptake and release of norepinephrine by synaptosomes

1970 • 53 citations

Correlation between the experimental data from animal studies and therapeutical effects of antidepressant drugs

1971 • 35 citations

Some observations on nerve-ending particles and synaptic vesicles

1964 • 35 citations

New Aspects of Storage and Release Mechanisms of Catecholamines.

1971 • 28 citations

Psychopharmacology

1970 • 27 citations

Psychiatrische Pharmakotherapie in Klinik und Praxis

1965 • 25 citations

Pharmacological and Biochemical Effects of Some Reserpine Derivatives

1961 • 21 citations

Inhibitory effect of two newer antidepressants, Lu 5-003 and Lu 3-010, on serotonin uptake in human blood platelets in vitro

1970 • 13 citations