Animal models in experimental hypertension: relevance to drug testing and discovery

Development of a Strain of Spontaneously Hypertensive Rats

1963 • 2,492 citations

STUDIES ON EXPERIMENTAL HYPERTENSION

1934 • 2,092 citations

Renin-angiotensin system: biochemistry and mechanisms of action.

1977 • 1,373 citations

Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis

1977 • 1,317 citations

Mechanisms regulating renin release

1976 • 886 citations

Emotions—Their Parameters and Measurement

1976 • 845 citations

Salt and hypertension

1972 • 667 citations

Textbook of medical physiology

1966 • 661 citations

Systemic arterial baroreceptor reflexes

1976 • 650 citations

Role of the Baroreceptor Reflex in Daily Control of Arterial Blood Pressure and Other Variables in Dogs

1973 • 586 citations

Neurogenic Hypertension in the Rat

1964 • 527 citations

Similarities of genetic (spontaneous) hypertension. Man and rat.

1981 • 511 citations

Active muscle vasodilatation produced by stimulation of the brain stem: its significance in the defence reaction

1960 • 482 citations

Integrative neural cardiovascular control.

1971 • 437 citations

EVIDENCE FOR TWO DISTINCT TYPES OF POSTSYNAPTIC α‐ADRENOCEPTOR IN VASCULAR SMOOTH MUSCLE in vivo

1979 • 433 citations

Reflexogenic Areas of the Cardiovascular System

1958 • 430 citations

Sympathetic nerve activity: role in regulation of blood pressure in the spontaenously hypertensive rat.

1976 • 429 citations

Role of Genetic Factors in Susceptibility to Experimental Hypertension due to Chronic Excess Salt Ingestion

1962 • 425 citations

Cardiovascular Structural Adaptation; its Role in the Initiation and Maintenance of Primary Hypertension

1978 • 410 citations

THE PRODUCTION OF PERSISTENT ARTERIAL HYPERTENSION BY CELLOPHANE PERINEPHRITIS

1939 • 406 citations

Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats.

1971 • 391 citations

Neuroanatomy of Central Cardiovascular Control. Nucleus Tractus Solitarii: Afferent and Efferent Neuronal Connections in Relation to the Baroreceptor Reflex Arc

1977 • 388 citations

Treatment of hypertension with nifedipine, a calcium antagonistic agent.

1979 • 357 citations

Permanent cannulation of aorta and vena cava in rats and ground squirrels

1960 • 342 citations

Circulatory Physiology: Cardiac Output and its Regulation.

1973 • 339 citations

Hypertension of Renal Origin: Evidence for Two Different Mechanisms

1971 • 338 citations

Pharmacology of Antihypertensive Drugs.

1980 • 330 citations

Acute Fulminating Neurogenic Hypertension Produced by Brainstem Lesions in the Rat

1973 • 321 citations

High sodium-low potassium environment and hypertension

1976 • 307 citations

Brief Reviews : A Systems Analysis Approach to Understanding Long-Range Arterial Blood Pressure Control and Hypertension

1974 • 298 citations

Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats

1973 • 288 citations

Hypertension: Physiopathology and Treatment

1984 • 282 citations

Control of Renin Secretion

1964 • 265 citations

Termination and secondary projections of carotid sinus nerve in the cat brain stem

1969 • 262 citations

The importance of vasopressin in the development and maintenance of DOC-salt hypertension in the rat.

1979 • 252 citations

RENAL CHANGES IN MALIGNANT HYPERTENSION

1939 • 249 citations

Nifedipine, a new antihypertensive with rapid action

1977 • 246 citations

Distribution of carotid sinus and depressor nerves in cat brain stem

1968 • 244 citations

Baroreceptors and hypertension

1968 • 241 citations

RECYCLING DISPOSABLES

1974 • 240 citations

The localization of the first synapse in the carotid sinus baroreceptor reflex pathway and its alteration of the afferent input

1969 • 234 citations

Malignant hypertension produced by treatment with desoxycorticosterone acetate and sodium chloride

1943 • 219 citations

Central adrenergic neurones and the initiation and development of experimental hypertension

1972 • 205 citations

Central and peripheral adrenergic mechanisms in the development of deoxycorticosterone-saline hypertension in rats.

1975 • 201 citations

Inherited Hypertension in Rats

1958 • 200 citations

Role of the intrarenal renin-angiotensin system in the control of renal function.

1981 • 195 citations

Routine Direct Measurement of Arterial Pressure in Unanesthetized Rats

1960 • 194 citations

ARTERIAL PRESSURE AND HYPERTENSION

1981 • 194 citations

Cardiovascular Effects of Acute and Chronic Stimulations of the Hypothalamic Defence Area in the Rat

1966 • 188 citations

Importance of renal sympathetic tone in the development of DOCA-salt hypertension in the rat.

1980 • 180 citations

Hyperresponsivitiy of spontaneously hypertensive rat to indirect measurement of blood pressure

1978 • 180 citations

Experimental epidemiology of chronic sodium chloride toxicity and the protective effect of potassium chloride

1958 • 179 citations

Renal and nephron hemodynamics in spontaneously hypertensive rats

1979 • 177 citations

A plethysmographic method for measuring systolic blood pressure in the intact rat

1938 • 175 citations

Vasopressor role of ADH in the pathogenesis of malignant DOC hypertension

1977 • 173 citations

Antihypertensive activity in rats for SQ 14,225, an orally active inhibitor of angiotensin I-converting enzyme.

1978 • 172 citations

Regulation of Blood Pressure by Sympathetic Nerve Fibers and Adrenal Medulla in Normotensive and Hypertensive Rats

1972 • 171 citations

Recent developments in noradrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents.

1980 • 169 citations

Das subkortikale Zentrum der affektiven Abwehrreaktion.

1943 • 168 citations

Role of Central and Peripheral Adrenergic Mechanisms in Neurogenic Hypertension Produced by Brainstem Lesions in Rat

1974 • 163 citations

CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT

1953 • 152 citations

Artery Wall Electrolytes in Renal and Dca hypertension1

1954 • 149 citations

The relationship of cardiac output and arterial pressure control.

1981 • 148 citations

Chronic labile hypertension produced by lesions of the nucleus tractus solitarii in the cat.

1977 • 145 citations

A Simplified Procedure for Inducing Chronic Renal Hypertension in the Mammal.

1944 • 145 citations

Renin, Aldosterone, Body Fluid Volumes, and the Baroreceptor Reflex in the Development and Reversal of Goldblatt Hypertension in Conscious Dogs

1974 • 142 citations

Sympathetic nerve activity and blood pressure in normotensive backcross rats genetically related to the spontaneously hypertensive rat.

1979 • 142 citations

Ways of viewing the central nervous control of the circulation — old and new

1975 • 141 citations

A solid silver clip for induction of predictable levels of renal hypertension in the rat.

1971 • 138 citations

Changes in renin, water balance, and sodium balance during development of high blood pressure in genetically hypertensive rats.

1975 • 138 citations

The renal circulation in hypertensive disease

1976 • 137 citations

Pharmacologic properties of minoxidil: a new hypotensive agent.

1973 • 133 citations

Circulatory Physiology II: Dynamics and Control of the Body Fluids.

1976 • 124 citations

Participation of Central Noradrenergic Neurons in Arterial Baroreceptor Reflexes in the Rabbit: A STUDY WITH INTRACISTERNALLY ADMINISTERED 6-HYDROXYDOPAMINE

1972 • 124 citations

The integration of autonomic system reactions: a discussion of autonomic reflexes, their control and their association with somatic reactions.

1972 • 124 citations

Cell permeability, sodium transport, and the hypertensive process in the rat.

1976 • 123 citations

Antihypertensive activity of N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro (MK-421), an orally active converting enzyme inhibitor.

1981 • 119 citations

Reciprocation of Renin Dependency with Sodium Volume Dependency in Renal Hypertension

1975 • 118 citations

Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension.

1980 • 115 citations

Reflex and Central Mechanisms involved in the Control of the Heart and Circulation

1974 • 115 citations

Captopril (SQ 14,225) (d-3-mercapto-2-methylpropanoyl-l-proline): A novel orally active inhibitor of angiotensin-converting enzyme and antihypertensive agent

1978 • 114 citations

Pharmacology of diazoxide, an antihypertensive, nondiuretic benzothiadiazine.

1962 • 113 citations

Neurophysiology and neuropharmacology of cardiovascular regulation and stress

1981 • 112 citations

Cardiovascular regulation by central adrenergic mechanisms and its alteration by hypotensive drugs.

1975 • 105 citations

EFFECTS OF CHRONIC EXCESS SALT INGESTION

1963 • 104 citations

Inhibition of angiotensin conversion and prevention of renal hypertension

1975 • 103 citations

Antihypertensive Agents.

1968 • 98 citations

Subpressor angiotensin infusion, renal sodium handling, and salt-induced hypertension in the dog.

1978 • 97 citations

The development of a new strain of spontaneously hypertensive rats.

1974 • 97 citations

Development of left ventricular hypertrophy in young spontaneously hypertensive rats after peripheral sympathectomy.

1977 • 95 citations

The pathogenesis of chronic renovascular hypertension.

1977 • 94 citations

Analysis of the hypotensive action of prazosin.

1975 • 91 citations

Bilateral renal function responses to converting enzyme inhibitor (SQ 20,881) in two-kidney, one clip Goldblatt hypertensive rats.

1981 • 89 citations

A method for production of experimental hypertension in rats

1968 • 88 citations

Characteristics of single carotid sinus baroreceptor fibers and whole nerve activity in the normotensive and the renal hypertensive dog.

1977 • 88 citations

Augmented sympathetic nerve activity and pressor responsiveness in DOCA hypertensive rats.

1980 • 85 citations

The integration of autonomic system reactions

2005 • 82 citations

Pharmacological actions of the antihypertensive agent N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride (BS 100-141).

1975 • 80 citations

Pathogenesis of the Cardiovascular and Renal Changes Which Usually Accompany Malignant Hypertension

1946 • 80 citations

Different antihypertensive effects of nifedipine in conscious experimental hypertensive and normotensive rats

1980 • 79 citations

Hemodynamic Characteristics of Chronic Experimental Neurogenic Hypertension in Unanesthetized Dogs

1969 • 77 citations

Quantification of baroreceptor influence on arterial pressure changes seen in primary angiotension-induced hypertension in dogs.

1976 • 76 citations

Pathogenesis of Arterial Hypertension after the Constriction of the Renal Artery Leaving the opposite Kidney Intact Both in the Anaesthetized and in the Conscious Dog

1972 • 75 citations

Central Inhibitory Noradrenergic Cardiovascular Control

1975 • 73 citations

Development of SHR hypertension and cardiac hypertrophy during prolonged beta blockade

1977 • 71 citations

The central modulatory effect of clonidine on the cardiodepressor reflex after suppression of synthesis and storage of noradrenaline

1975 • 71 citations

Diuretic and Diet Treatment of Hypertension

1974 • 70 citations

Autoregulation of renal blood flow in spontaneously hypertensive rats.

1979 • 70 citations

A comparison of the effects of prazosin and hydrallazine on blood pressure, heart rate and plasma renin activity in conscious renal hypertensive dogs

1975 • 68 citations

ARTERIAL HYPERTENSION IN THE CHICKEN

1948 • 68 citations

Effects of Captopril in Animal Models of Hypertension

1980 • 68 citations

Natural history and pathogenesis of renal ablation hypertension.

1960 • 66 citations

The role of angiotensin in thirst

1975 • 66 citations

Vasopressor role of ADH in the pathogenesis of malignant DOC hypertension

1977 • 66 citations

The relation of arterial pressure and plasma angiotensin II concentration. A change produced by prolonged infusion of angiotensin II in the conscious dog.

1979 • 66 citations

Renal innervation and renin activity in salt metabolism and hypertension

1969 • 65 citations

Lack of correlation between direct and indirect measurements of arterial pressure in unanaesthetized rats

1971 • 63 citations

Chronic antihypertensive effects of captopril (SQ 14,225), an orally active angiotensin I-converting enzyme inhibitor, in conscious 2-kidney renal hypertensive rats

1978 • 62 citations

Role of the Renin-Angiotensin System In the Pathogenesis of Severe Hypertension in Rats

1971 • 61 citations

Antihypertensive Agents.

1978 • 59 citations

Antihypertensive and hemodynamic actions of SCH 19927, the R,R-isomer and labetalol.

1981 • 58 citations

Potassium and blood vessels

1975 • 58 citations

Blood pressure and plasma angiotensin II concentration after renal artery constriction and angiotensin infusion in the dog. (5-Isoleucine)angiotensin II and its breakdown fragments in dog blood.

1976 • 57 citations

Vascular Hyper-Reactivity with Sodium Loading and with Desoxycorticosterone Induced Hypertension in the Rat

1970 • 57 citations

An assessment of the role of the sympathetic nervous system in experimental hypertension using normal and immunosympathectomized rats

1970 • 55 citations

FACTORS AFFECTING INDIRECT DETERMINATION OF SYSTOLIC BLOOD PRESSURE OF RATS.

1963 • 54 citations

Production of Nephrosclerosis by Overdosage with Desoxycorticosterone Acetate.

1942 • 53 citations

SALT AND HYPERTENSION*

1978 • 53 citations

Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig.

1977 • 52 citations

Effects of angiotensen antagonist in rats with acute, subacute, and chronic two-kidney renal hypertension.

1978 • 52 citations

Plasma renin and sodium balance during development of moderate and severe renal hypertension in rats.

1975 • 51 citations

Indirect measurement of instantaneous arterial blood pressure in the rat

1979 • 50 citations

Differential Development of Renal, Doca-salt, and Spontaneous Hypertension in the Rat After Neonatal Sympathectomy

1978 • 48 citations

Effects of continuous converting enzyme blockade on renovascular hypertension in the rat

1979 • 48 citations

The rat with spontaneous genetic hypertension is not a suitable model of human essential hypertension.

1981 • 47 citations

A comparison of some cardiovascular properties of propranolol, MJ 1999 and quinidine in relation to their effects in hypertensive animals

1968 • 47 citations

Angiotensin on Vascular Smooth Muscle

1974 • 46 citations

Local Control of Vascular Resistance

1974 • 46 citations

Relationship between Noradrenaline-Induced Depolarization and Contraction in Vascular Smooth Muscle

1978 • 45 citations

Neuronal Mechanisms Influencing Transmission in the Baroreceptor Reflex Arc

1977 • 45 citations

Hypertension: Mechanisms and management

1982 • 44 citations

Hypertensive vascular disease produced by salt.

1958 • 44 citations

Interrelationship of renin content in kidneys and blood pressure in renal hypertensive rats.

1962 • 42 citations

Epidemiology of hypertension

1965 • 42 citations

Plasma renin activity during pentobarbital anesthesia and graded hemorrhage in dogs

1975 • 41 citations

Hypertension following denervation of aortic baroreceptors in unanesthetized dogs.

1979 • 39 citations

ACCURACY OF INDIRECT DETERMINATIONS OF BLOOD PRESSURE IN THE RAT; RELATION TO TEMPERATURE OF PLETHYSMOGRAPH AND WIDTH OF CUFF

1946 • 37 citations

The Role of the Baroreceptor Reflex in the Cardiovascular Effects of Propranolol in the Conscious Spontaneously Hypertensive Rat

1979 • 37 citations

THE BIOLOGY OF METACORTICOID HYPERTENSION

1958 • 36 citations

Salt Appetite, Salt Intake, and Hypertension: A Deviation of Perspective

1978 • 36 citations

Brief Reviews : Arterial Hypertension in Retrospect

1974 • 36 citations

New trends in arterial hypertension

1982 • 35 citations

Role of Sodium Chloride in Production of Nephrosclerosis by Steroids

1943 • 35 citations

The role of the kidney in essential hypertension

1975 • 34 citations

Destruction of the nucleus tractus solitarii in the dog: comparison with sinoaortic denervation

1979 • 34 citations

The role of salt in experimental and human hypertension

1972 • 34 citations

Role of the retention of water and sodium in two types of experimental renovascular hypertension in the rat

1973 • 34 citations

Experimental Unilateral Renal Artery Constriction in the Dog

1972 • 33 citations

Participation of central noradrenergic neurons in experimental hypertension

1977 • 32 citations

The role of arterial baroreceptors in the regulation of arterial pressure in conscious dogs.

1976 • 32 citations

Antagonism of peripheral and central effects of angiotensin II by (1-sarcosine, 8-isoleucine)angiotensin II.

1973 • 31 citations

The direct and indirect measurement of blood pressure

1970 • 31 citations

Accelerated Induction of Two-Kidney Hypertension in Rats and Renin-Angiotensin Sensitivity

1974 • 31 citations

Mechanism of postarrhythmic renal vasoconstriction in the anesthetized dog.

1979 • 30 citations

Central and peripheral α-adrenergic effects of some imidazolidines

1977 • 30 citations

Chronic propranolol treatment inhibits sympathetic nerve activity and keeps blood pressure from rising in spontaneously hypertensive rats.

1980 • 30 citations

Reversibility of Baroreceptor Adaptation in Chronic Hypertension

1973 • 30 citations

An externally adjustable renal artery clamp.

1971 • 30 citations

Effect of Various Lesions in the Nucleus Tractus Solitarii of the Rat on Blood Pressure, Heart Rate and Cardiovascular Reflex Responses

1978 • 30 citations

AN ANTIHYPERTENSIVE ACTION OF PROPRANOLOL IN DOCA/SALT-TREATED RATS

1974 • 30 citations

Central inhibitory effect of α-methyldopa on blood pressure, heart rate and body temperature of renal hypertensive rats

1975 • 29 citations

Cellophane Perinephritis Hypertension and Its Reversal in Rabbits

1973 • 29 citations

Morphological aspects of the renin-angiotensin system.

1971 • 28 citations

Cardiovascular pharmacology

1978 • 28 citations

Effects of renal artery constriction and subsequent contralateral nephrectomy on the blood pressure, plasma renin activity, and plasma renin substrate concentration in rabbits.

1970 • 28 citations

Renal Hemodynamics and Plasma Renin Activity after Renal Artery Constriction in Conscious Dogs

1972 • 27 citations

Effects of antihypertensive drugs in the spontaneously hypertensive rat

1970 • 27 citations

Prazosin and Phentolamine: Comparative Cardiovascular and Autonomic Profiles

1978 • 27 citations

Rigid clip for standardized hypertension in the rabbit.

1971 • 26 citations

Sympathetic and renin-angiotensin system influence on blood pressure and renal blood flow of two-kidney, one clip Goldblatt hypertensive dog.

1980 • 26 citations

Beta-adrenergic receptor blocking drugs in spontaneous hypertension

1976 • 26 citations

2,6-Dichlorobenzylidene amino guanidine acetate (Wy-8678). A new hypotensive agent

1969 • 26 citations

Mechanisms involved in two-kidney renal hypertension induced by constriction of one renal artery.

1977 • 26 citations

The influence of acute sodium depletion on experimental hypertension in the rat.

1971 • 26 citations

THE MEASUREMENT OF THE BLOOD PRESSURE IN RATS WITH SPECIAL REFERENCE TO THE EFFECT OF CHANGES IN TEMPERATURE

1945 • 25 citations

The effect of high sodium intake and angiotensin antagonist in rabbits with severe and moderate hypertension induced by constriction of one renal artery.

1977 • 25 citations

ACCELERATED APPEARANCE OF DCA HYPERTENSION IN RATS TREATED WITH PITRESSIN¹

1960 • 25 citations

Mechanism of Antihypertensive Activity of Orally Administered Prazosin in Spontaneously Hypertensive Rats

1979 • 24 citations

Cerebral Mechanisms and Neurogenic Hypertension in Man, with Special Reference to Baroreceptor Control

1977 • 24 citations

Plasma renin and angiotensin levels in experimental hypertension in the rat.

1975 • 23 citations

Self-sustained hypertension in the albino rat; a hypothesis to explain it.

1949 • 23 citations

Prazosin in the Treatment of Hypertension

1974 • 22 citations

Evaluation of antihypertensive agents in the stress-induced hypertensive rat

1975 • 22 citations

Indirect blood pressure measurement in the dog.

1975 • 21 citations

Renin release and pressor response to renal arterial hypotension: effect of dietary sodium

1977 • 21 citations

Indirect blood pressure measurements in the rabbit: correlations with direct aortic and ear pressures.

1975 • 21 citations

Plasma Renin Activity and Sodium, Potassium and Water Excretion during Reversal of Hypertension in the One-Clip, Two-Kidney Hypertensive Rat

1979 • 21 citations

Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats.

1980 • 20 citations

Prazosin in treatment of hypertension

1975 • 20 citations

Effect of Antihypertensive Drugs on the Renin-Angiotensin System

1976 • 20 citations

Circulatory and Humoral Changes in the Reversal of Renovascular Hypertension in Sheep by Unclipping the Renal Artery

1970 • 20 citations

Long-Term Efficacy of Captopril (SQ 14,225) In 2-Kidney Renal Hypertensive Rats

1979 • 20 citations

Failure of chronic aldosterone infusion to increase arterial pressure in dogs with angiotensin-induced hypertension.

1978 • 20 citations

Diminished sympathetic silent period in spontaneously hypertensive rats

1979 • 20 citations

Mechanisms of hypertension during the acute and intermediate phases of the one-clip, two-kidney model in the dog.

1977 • 20 citations

Centrally Induced Hypotension by α-Methyldopa and α-Methylnoradrenaline in Normotensive and Renal Hypertensive Rats

1977 • 19 citations

Altered norepinephrine synthesis of splanchnic vessels in neurogenic hypertension

1974 • 19 citations

DESOXYCORTICOSTERONE IN RABBITS: SIMULATION OF RABBIT “TOXEMIA OF PREGNANCY”*

1953 • 18 citations

Hypotensive actions of drugs on unanesthetized normotensive and "metacorticoid" hypertensive rats determined by a direct recording technique.

1965 • 18 citations

Hypertension and the Kidney

1974 • 18 citations

Autonomic Control of the Peripheral Vascular System

1970 • 18 citations

Discontinuation syndrome after continuous infusion of clonidine in the spontaneously hypertensive rat

1981 • 18 citations

Effect of blockade of angiotensin-I converting enzyme on the blood pressure of renal hypertensive rabbits

1974 • 17 citations

Mechanism of enhanced blood pressure rise after reclipping following removal of a renal artery clip in rats.

1980 • 17 citations

Role of released catecholamines in the vascular response to injected angiotensin II in the dog.

1981 • 17 citations

Effect of Propranolol on Blood Pressure in Normal and Hypertensive Rats

1974 • 17 citations

Experimental hypertension of renal origin in the rabbit

1939 • 17 citations

Effects of reserpine on blood pressure and vascular electrolytes in hypertension

1967 • 15 citations

Cardiovascular properties of antihypertensive drugs in a model of severe renal hypertension

1979 • 15 citations

Influence of the adrenergic system in renovascular hypertension

1971 • 15 citations

Role of the Adrenal Glands in the Development of Severe Hypertension

1973 • 15 citations

Neurogenic Activity–Angiotensin II Interaction during the Development and Maintenance of Renal Hypertension in the Rat

1979 • 15 citations

Effect of Administration of Sar1-Ala8-Angiotensin II during the Development and Maintenance of Renal Hypertension in the Rat

1978 • 14 citations

The effect of D- and DL-propranolol on blood pressure and cerebral norepinephrine in rats with DOCA-hypertension.

1972 • 14 citations

Involvement of angiotensin-mediated renal vasoconstriction in renal hypertension

1973 • 13 citations

A New Simple Method for Indirect Determination of Blood Pressure in the Rat.

1957 • 13 citations

The Baroreceptor Reflexes in Experimental Hypertension

1980 • 13 citations

Time-Course of the Reduction of Baroreceptor Sensitivity in Experimental Hypertensive Rabbits

1976 • 13 citations

COMPARISON OF DIRECT AND INDIRECT BLOOD PRESSURE MEASUREMENTS IN RATS

1944 • 12 citations

Mechanisms of hypertension during the chronic phase of the one-clip, two-kidney model in the dog.

1977 • 12 citations

Renin secretion in the earliest stage of goldblatt-type hypertension in rats

1972 • 12 citations

Urinary Kallikrein and Plasma Renin during the Reversal of Renovascular Hypertension in Rats

1976 • 12 citations

Antihypertensive activity of captopril (SQ 14,225), an orally active inhibitor of angiotensin converting enzyme in conscious two-kidney perinephritic hypertensive dogs.

1981 • 11 citations

The Ninth J. A. F. Stevenson Memorial Lecture The many roles of the kidney in arterial pressure control and hypertension

1981 • 11 citations

Sodium Retention Versus Renin–Angiotensin System In Experimental Renal Hypertension

1973 • 11 citations

Relative Effectiveness of Chlorothiazide, Reserpine and Hydrallazine in Spontaneously Hypertensive Rats

1976 • 10 citations

Partition of carotid sinus baroreceptor response in dogs with chronic renal hypertension.

1981 • 10 citations

Antihypertensive effect of nifedipine on conscious renal-hypertensive dogs.

1979 • 10 citations

Thyroid Function and Blood Pressure in Two New Strains of Spontaneously Hypertensive and Normotensive Rats

1978 • 10 citations

Hypotensive action of clonidine after adrenalectomy in the rat

1977 • 10 citations

Comparative Effects of Currently Available Antihypertensive Agents on Sponaneously and Renal Hypertensive Rats

1970 • 9 citations

An opposing role for the adrenals in the hypotensive effects of propranolol in the spontaneously hypertensive rat

1979 • 9 citations

Vascular responses of the perfused intestine to vasoactive agents during the development of two-kidney, one-clip Goldblatt hypertension in dogs.

1981 • 9 citations

Role of the Renin-Angiotensin System in Dogs with Perinephritis Hypertension

1976 • 8 citations

Hypertension and Brain Catecholamine Distribution in the Hebrew University Sabra, H and N Rats

1978 • 8 citations

Angiotensin II antagonists in dehydrated rabbits without baroreceptor reflexes

1977 • 7 citations

Differential antihypertensive effects of clonidine in different models of experimental hypertension in rats

1979 • 6 citations

Experimental analysis of some cardiovascular effects of St 600, clonidine (St 155) and guanabenz (BR 750).

1977 • 5 citations

Evidence for the involvement of α-adrenoceptor blockade in the antihypertensive action of diazoxide in the renal hypertensive rat

1975 • 4 citations

Increase in plasma renin activity, water intake and blood pressure following application and reapplication of a renal artery clip

1980 • 4 citations

Time course of the enhanced blood pressure response to reinduction of renal artery stenosis in unclipped renal hypertensive rats

1979 • 4 citations

Drug induced variations of the renin-angiotensin-aldosterone system in rats. II. Antihypertensives

1977 • 3 citations

Deleted Work

1955 • 0 citations