Lactoferrin

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

A component of innate immunity prevents bacterial biofilm development

2002 • 1,002 citations

LACTOFERRIN, AN IRON-BINBING PROTEIN NI NEUTROPHILIC LEUKOCYTES

1969 • 697 citations

A Bactericidal Effect for Human Lactoferrin

1977 • 688 citations

Lactoferrin: a general review.

1995 • 652 citations

An iron-binding protein common to many external secretions

1966 • 589 citations

Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin

1988 • 526 citations

Role of Iron in Bacterial Infection

1978 • 493 citations

Biological role of lactoferrin.

1992 • 481 citations

Antiviral activities of lactoferrin

2001 • 460 citations

Iron homeostasis: insights from genetics and animal models

2000 • 410 citations

The physiology of lactoferrin

2002 • 402 citations

Structure of human lactoferrin at 3.2-A resolution.

1987 • 375 citations

The antimicrobial activity of lactoferrin: Current status and perspectives

2004 • 364 citations

Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA

1995 • 349 citations

Lactoferrin is a lipid A-binding protein

1994 • 341 citations

Lactoferrin: A Multifunctional Glycoprotein Involved in the Modulation of the Inflammatory Process

1999 • 341 citations

Molecular Cloning and Functional Expression of a Human Intestinal Lactoferrin Receptor

2001 • 327 citations

Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-κB

2002 • 321 citations

Lactoferrin and host defense

2002 • 286 citations

Regulation of cytokine release from mononuclear cells by the iron- binding protein lactoferrin

1992 • 284 citations

Lactoferrin Is a Potent Regulator of Bone Cell Activity and Increases Bone Formation in Vivo

2004 • 272 citations

ASSOCIATION OF LACTOFERRIN WITH SPECIFIC GRANULES IN RABBIT HETEROPHIL LEUKOCYTES

1970 • 266 citations

Lactoferrin-lipopolysaccharide interaction: involvement of the 28-34 loop region of human lactoferrin in the high-affinity binding to Escherichia coli 055B5 lipopolysaccharide

1995 • 242 citations

Lactoferrin in human milk: its role in iron absorption and protection against enteric infection in the newborn infant.

1980 • 239 citations

Dealing with iron: Common structural principles in proteins that transport iron and heme

2003 • 236 citations

Persistence of Human Milk Proteins in the Breast‐Fed Infant

1987 • 235 citations

Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo.

1993 • 233 citations

Delineation of the glycosaminoglycan-binding site in the human inflammatory response protein lactoferrin.

1994 • 225 citations

The orchestration of body iron intake: how and where do enterocytes receive their cues?

2003 • 217 citations

Bovine lactoferrin and lactoferricin derived from milk: production and applications

2002 • 213 citations

Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells

2003 • 213 citations

PspA Protects Streptococcus pneumoniae from Killing by Apolactoferrin, and Antibody to PspA Enhances Killing of Pneumococci by Apolactoferrin

2004 • 209 citations

Interleukin‐18 acts as an angiogenesis and tumor suppressor

1999 • 208 citations

Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice.

1994 • 199 citations

Bovine Lactoferrin and Lactoferricin, a Peptide Derived from Bovine Lactoferrin, Inhibit Tumor Metastasis in Mice

1997 • 190 citations

Invivoantimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence

2000 • 187 citations

A System for Production of Commercial Quantities of Human Lactoferrin: A Broad Spectrum Natural Antibiotic

1995 • 182 citations

Lactoferrin, lactoferrin receptors and iron metabolism.

1993 • 180 citations

Fecal lactoferrin as a marker for disease activity in inflammatory bowel disease: comparison with other neutrophil-derived proteins.

1996 • 178 citations

Lactoferricin Derived From Milk Protein Lactoferrin

2003 • 175 citations

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

1993 • 167 citations

Receptor binding of lactoferrin by human monocytes

1983 • 165 citations

The binding of human lactoferrin to mouse peritoneal cells.

1976 • 164 citations

Cancer prevention by bovine lactoferrin and underlying mechanisms — a review of experimental and clinical studies

2002 • 163 citations

Expression of human lactotransferrin receptors in phytohemagglutinin‐stimulated human peripheral blood lymphocytes

1989 • 162 citations

The Protective Effects of Lactoferrin Feeding against Endotoxin Lethal Shock in Germfree Piglets

1998 • 162 citations

The Low-Density Lipoprotein Receptor-Related Protein 1 Is a Mitogenic Receptor for Lactoferrin in Osteoblastic Cells

2004 • 161 citations

Transferrin and lactoferrin undergo proteolytic cleavage in the Pseudomonas aeruginosa-infected lungs of patients with cystic fibrosis

1993 • 154 citations

Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin

1992 • 152 citations

Interleukin-18: recent advances

2004 • 149 citations

Lactoferrin gene expression and regulation: an overview

2002 • 148 citations

The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide.

1984 • 147 citations

Human Lactoferrin Stimulates Thymidine Incorporation into DNA of Rat Crypt Cells

1987 • 147 citations

Lactoferrin and host defence: an overview of its immuno-modulating and anti-inflammatory properties

2004 • 144 citations

Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells

1999 • 142 citations

Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo.

1989 • 136 citations

Activation of Intestinal Mucosal Immunity in Tumor‐bearing Mice by Lactoferrin

2000 • 136 citations

Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae

1998 • 131 citations

Orally Administered Lactoferrin Exerts an Antimetastatic Effect and Enhances Production of IL-18 in the Intestinal Epithelium

2000 • 131 citations

Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy

2004 • 130 citations

The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis

1994 • 129 citations

Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice.

1999 • 129 citations

Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance

2002 • 127 citations

Influence of Lactoferrin on Iron Absorption from Human Milk in Infants

1994 • 126 citations

Pleiotropic function of Toll-like receptors

2004 • 122 citations

Antimicrobial and immunoregulatory functions of lactoferrin and its potential therapeutic application

2002 • 119 citations

Lactoferrin reduces in vitro osteoclast differentiation and resorbing activity

2002 • 111 citations

Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells

1998 • 111 citations

Lactoferrin, a Potent Tryptase Inhibitor, Abolishes Late-Phase Airway Responses in Allergic Sheep

1997 • 109 citations

Inhibition of Azoxymethane‐initiated Colon Tumor by Bovine Lactoferrin Administration in F344 Rats

1997 • 109 citations

Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine‐rich sites

2003 • 108 citations

Lactoferrin Impairs Type III Secretory System Function in EnteropathogenicEscherichia coli

2003 • 107 citations

Lactoferrin biosynthesis during granulocytopoiesis

1984 • 106 citations

Iron Status in Mice Carrying a Targeted Disruption of Lactoferrin

2002 • 106 citations

IL-1β-induced Langerhans’ cell migration and TNF-αproduction in human skin: regulation by lactoferrin

2003 • 106 citations

Lactoferrin binding sites and nuclear localization in K562(S) cells

1992 • 105 citations

Lactoferrin protects gut mucosal integrity during endotoxemia induced by lipopolysaccharide in mice.

2000 • 105 citations

Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance

2002 • 104 citations

Lactoferrin upregulates the expression of CD4 antigen through the stimulation of the mitogen-activated protein kinase in the human lymphoblastic T Jurkat cell line

2000 • 103 citations

Oral Administration of Lactoferrin Inhibits Inflammation and Nociception in Rat Adjuvant-Induced Arthritis

2004 • 102 citations

Bovine lactoferrin inhibits tumor‐induced angiogenesis

2004 • 102 citations

Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines

1997 • 101 citations

Human Lactoferrin Impairs Virulence ofShigella flexneri

2002 • 101 citations

Enhanced Th1 Response to Staphylococcus aureus Infection in Human Lactoferrin-Transgenic Mice

2002 • 99 citations

Characterization of mammalian receptors for lactoferrin

2002 • 99 citations

Lactoferrin Down-Regulates G1 Cyclin-Dependent Kinases during Growth Arrest of Head and Neck Cancer Cells

2004 • 98 citations

Lactoferrin Binds CpG-Containing Oligonucleotides and Inhibits Their Immunostimulatory Effects on Human B Cells

2001 • 97 citations

Lactoferrin-mediated protection of the host from murine cytomegalovirus infection by a T-cell-dependent augmentation of natural killer cell activity

1996 • 94 citations

Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats

2004 • 92 citations

Possible Chemopreventive Effects of Bovine Lactoferrin on Esophagus and Lung Carcinogenesis in the Rat

1999 • 88 citations

Effects of Lactoferrin and Its Peptides on Proliferation of Rat Intestinal Epithelial Cell Line, IEC-18, in the Presence of Epidermal Growth Factor

1995 • 88 citations

Immunochemical detection of human lactoferrin in feces as a new marker for inflammatory gastrointestinal disorders and colon cancer

1994 • 85 citations

Antiviral activity of lactoferrin towards naked viruses

2004 • 82 citations

Anti‐Inflammatory Activities of Human Lactoferrin in Acute Dextran Sulphate‐Induced Colitis in Mice

2003 • 82 citations

Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression

1995 • 82 citations

Lactoferrin specifically inhibits endocytosis of chylomicron remnants but not alpha-macroglobulin.

1992 • 80 citations

Regulation of epidermal Langerhans cell migration by lactoferrin

2000 • 79 citations

Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor α or 1-methyl-4-phenylpyridinium treatment

2001 • 79 citations

Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans

2001 • 72 citations

Bacteriostatic activity of bovine milk lactoferrin against mastitic bacteria

1986 • 71 citations

Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis

2003 • 66 citations

Human Lactoferrin Activates Transcription of IL-1β Gene in Mammalian Cells

2002 • 65 citations

Monocyte and NK cell cytotoxic activity in human adherent cell preparations: discriminating effects of interferon and lactoferrin.

1984 • 64 citations

Neutrophil lactoferrin upregulates the human p53 gene through induction of NF-κB activation cascade

2004 • 63 citations

The Therapeutic Effect of Bovine Lactoferrin in the Host Infected withHelicobacter pylori

1999 • 62 citations

Human Neutrophil Lactoferrin trans-Activates the Matrix Metalloproteinase 1 Gene through Stress-activated MAPK Signaling Modules

2001 • 62 citations

Bacterial Lactoferrin Receptors

1998 • 61 citations

Uptake and handling of iron from transferrin, lactoferrin and immune complexes by a macrophage cell line

1988 • 59 citations

Chemopreventive Effect of Bovine Lactoferrin on 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinogenesis in Male F344 Rats

2000 • 59 citations

Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemic cells, and breast cancer.

1991 • 58 citations

Restricted Spatiotemporal Expression of Lactoferrin during Murine Embryonic Development

1999 • 58 citations

Influence of lactoferrin on the entry process of Escherichia coli HB101(pRI203) in HeLa cells

1993 • 56 citations

Expression and prognostic value of lactoferrin mRNA isoforms in human breast cancer

2004 • 53 citations

Iron Saturation Alters the Effect of Lactoferrin on the Proliferation and Differentiation of Human Enterocytes (Caco-2 Cells)

1995 • 53 citations

Chemopreventive Effects of Bovine Lactoferrin on N‐Butyl‐N‐(4‐ hydroxybutyl)nitrosamine‐induced Rat Bladder Carcinogenesis

2000 • 52 citations

Iron Is Not Required in the Lactoferrin Stimulation of Thymidine Incorporation into the DNA of Rat Crypt Enterocytes

1990 • 50 citations

Effect of lactoferrin onHelicobacter felisinduced gastritis

2002 • 50 citations

Lactoferrin and secretory IgA in the bronchoalveolar lavage fluid from patients with a stable asthma

1991 • 49 citations

Respiratory epithelial cells demonstrate lactoferrin receptors that increase after metal exposure

1999 • 48 citations

Human lactoferrin proteolytic activity: analysis of the cleaved region in the IgA protease of Haemophilus influenzae

2000 • 47 citations

Isolation of a lactoferrin cDNA clone and its expression in human breast cancer

1992 • 46 citations

Release of lactoferrin and elastase in human allergic skin reactions.

1990 • 44 citations

Methylation and expression of the lactoferrin gene in human tissues and cancer cells

2004 • 41 citations

Lactoferrin derived from neutrophils inhibits the mixed lymphocyte reaction

1987 • 41 citations

Down‐regulation of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx)‐induced CYP1A2 Expression Is Associated with Bovine Lactoferrin Inhibition of MeIQx‐induced Liver and Colon Carcinogenesis in Rats

2002 • 40 citations

Lactoferrin Inhibits Growth of Malignant Tumors of the Head and Neck

2003 • 40 citations

Lactoferrin receptors in normal and leukaemic human blood cells

1984 • 39 citations

Recombinant human lactoferrin prevents NSAID-induced intestinal bleeding in rodents

2004 • 38 citations

Lactoferrin‐an iron binding protein in synovial fluid

1973 • 37 citations

Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat

2004 • 37 citations

Differential Excretion of Leucocyte Granule Components in Inflammatory Bowel Disease: Implications for Pathogenesis

1997 • 27 citations

Lactoferrin expression in human breast cancer.

1999 • 22 citations

Comparative Physiology of Lactation [Abridged]

1972 • 11 citations

Regulation by Lactoferrin of Epidermal Langerhans Cell Migration

1998 • 8 citations