Lactoferrin: a general review.

THE PHENOMENON OF THE ACUTE PHASE RESPONSE*

1982 • 1,498 citations

Iron withholding: a defense against infection and neoplasia.

1984 • 893 citations

A Bactericidal Effect for Human Lactoferrin

1977 • 688 citations

Stoichiometric and site characteristics of the binding of iron to human transferrin.

1978 • 585 citations

Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N‐terminal region of bovine lactoferrin

1992 • 573 citations

Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins

1984 • 531 citations

Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment

1993 • 494 citations

Biological role of lactoferrin.

1992 • 481 citations

Lactoferrin in milk from different species

1971 • 433 citations

Lactoferrin and transferrin: A comparative study

1972 • 335 citations

Iron absorption in infants: High bioavailability ofbreast milk iron as indicated by the extrinsic tag method of iron absorption and by the concentration of serum ferritin

1977 • 323 citations

Isolation of an Iron-Containing Red Protein from Human Milk.

1960 • 297 citations

THE INVOLVEMENT OF LACTOFERRIN IN THE HYPOSIDEREMIA OF ACUTE INFLAMMATION

1974 • 294 citations

Regulation of cytokine release from mononuclear cells by the iron- binding protein lactoferrin

1992 • 284 citations

Inhibition of lipid peroxidation by the iron-binding protein lactoferrin

1981 • 258 citations

Iron and infection: molecular, physiological and clinical aspects.

1999 • 247 citations

The detection of four molecular forms of human transferrin during the iron binding process

1976 • 232 citations

Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin

1993 • 219 citations

Distribution of transferrin, ferritin, and lactoferrin in human tissues.

1978 • 201 citations

New perspectives on the structure and function of transferrins

1992 • 201 citations

Rapid membrane permeabilization and inhibition of vital functions of gram-negative bacteria by bactenecins

1990 • 199 citations

Molecular Weight, Single‐Chain Structure and Amino Acid Composition of Human Lactoferrin

1971 • 197 citations

Isolation and function of a receptor for human lactoferrin in human fetal intestinal brush-border membranes

1991 • 180 citations

Lactoferrin, lactoferrin receptors and iron metabolism.

1993 • 180 citations

COMPONENTS OF HUMAN SPLIT EJACULATES

1975 • 178 citations

Lactoferrin Deficiency Associated with Altered Granulocyte Function

1982 • 172 citations

Lysozyme, lactoferrin, and secretory immunoglobulin A content in breast milk: influence of duration of lactation, nutrition status, prolactin status, and parity of mother

1991 • 170 citations

The binding of human lactoferrin to mouse peritoneal cells.

1976 • 164 citations

The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrumUnusual resistance of human apolactoferrin to proteolytic digestion

1983 • 153 citations

Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin

1992 • 152 citations

Lactoferrin levels in normal human tears.

1983 • 150 citations

Neutrophil-macrophage cooperation in the host defence against mycobacterial infections

1989 • 150 citations

Human Lactoferrin Stimulates Thymidine Incorporation into DNA of Rat Crypt Cells

1987 • 147 citations

Serum Myeloperoxidase and Lactoferrin in Neutropenia

1977 • 143 citations

Lactoferrin Content of Peripheral Blood Cells

1978 • 139 citations

Influence of Lactoferrin on the Function of Human Polymorphonuclear Leukocytes and Monocytes

1991 • 139 citations

Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease.

1993 • 138 citations

Preliminary observations on lactoferrin secretion in human vaginal mucus: Variation during the menstrual cycle, evidence of hormonal regulation, and implications for infection with Neisseria gonorrhoeae

1987 • 137 citations

Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo.

1989 • 136 citations

The non-immune inflammatory response: Serial changes in plasma iron, iron-binding capacity, lactoferrin, ferritin and C-reactive protein

1986 • 131 citations

Origin of Intact Lactoferrin and Its DNA-Binding Fragments Found in the Urine of Human Milk-Fed Preterm Infants. Evaluation by Stable Isotopic Enrichment

1991 • 127 citations

Plasma Myeloperoxidase and Lactoferrin Measured by Radioimmunoassay: Relations to Neutrophil Kinetics

1975 • 113 citations

An enzyme-linked immunoassay (ELISA) for measurement of lactoferrin

1983 • 113 citations

Components of human split ejaculates

1976 • 110 citations

Lactoferrin binding sites and nuclear localization in K562(S) cells

1992 • 105 citations

Colostrum-Induced Enteric Mucosal Growth in Beagle Puppies

1984 • 105 citations

Markers of Mucus Secretion and DNA Levels in Induced Sputum from Asthmatic and from Healthy Subjects

1993 • 104 citations

Oxidative Metabolism of Cord Blood Neutrophils: Relationship to Content and Degranulation of Cytoplasmic Granules

1984 • 102 citations

Concentrations of lactoferrin and iron in human milk at different stages of lactation.

1990 • 98 citations

Abnormal stimulated adherence of neonatal granulocytes: impaired induction of surface Mac-1 by chemotactic factors or secretagogues

1987 • 96 citations

A solid-phase radioimmunoassay for the measurement of lactoferrin in human plasma: variations with age, sex, and disease.

1976 • 95 citations

Membrane-bound lactoferrin alters the surface properties of polymorphonuclear leukocytes.

1982 • 93 citations

Lactotransferrin binding to its platelet receptor inhibits platelet aggregation

1993 • 93 citations

Zinc binding in cow's milk and human milk

1983 • 89 citations

Comparison of the gastrointestinal growth-promoting effects of rat colostrum and mature milk in newborn rats in vivo

1983 • 89 citations

Molecular Forms of Lactoferrin in Stool and Urine from Infants Fed Human Milk

1990 • 88 citations

Lactoferrin and Iron Absorption in Newborn Infants

1987 • 87 citations

Lactoferrin in plasma measured by an ELISA technique: Evidence that plasma lactoferrin is an indicator of neutrophil turnover and bone marrow activity in acute leukaemia

1985 • 86 citations

Relationship between antibacterial activity and porin binding of lactoferrin in Escherichia coli and Salmonella typhimurium

1993 • 84 citations

Lactoferrin Turnover in Man

1979 • 83 citations

Anti‐Infective Factors in Preterm Human Colostrum

1990 • 83 citations

Interaction of bovine lactoferrin with other proteins of milk whey

1990 • 79 citations

Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn

1989 • 76 citations

Isolation of Crystalline Lactoferrin from Human Milk.

1969 • 75 citations

Characterization of the human transferrin and lactoferrin receptors in Haemophilus influenzae

1988 • 72 citations

Inflammatory markers in cystic fibrosis

1991 • 68 citations

Calcium-dependent polymerization of lactoferrin

1981 • 64 citations

Heparin-binding properties of lactoferrin and lysozyme

1992 • 63 citations

The N‐terminal domain I of human lactotransferrin binds specifically to phytohemagglutinin‐stimulated peripheral blood human lymphocyte receptors

1989 • 61 citations

Myeloperoxidase and Lactoferrin of Blood Neutrophils and Plasma in Chronic Granulocytic Leukaemia

1977 • 60 citations

Presence of an Iron-binding Protein (Lactoferrin) in the Genital Tract of the Human Female

1968 • 58 citations

Identification of a human lactoferrin-binding protein in Staphylococcus aureus

1992 • 58 citations

Lactoferrin, transferrin and acidic isoferritins: regulatory molecules with potential therapeutic value in leukemia.

1983 • 56 citations

Human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation

1987 • 52 citations

Primary structure of glycans isolated from human leucocyte lactotransferrin. Absence of fucose residues questions the proposed mechanism of hyposideraemia

1990 • 52 citations

The biological significance of lactoferrin in haematology

1984 • 50 citations

Iron Is Not Required in the Lactoferrin Stimulation of Thymidine Incorporation into the DNA of Rat Crypt Enterocytes

1990 • 50 citations

Lactoferrin and lysozyme levels in synovial fluid

1977 • 50 citations

Ontogenesis of the secretory immune system and innate defence factors in human parotid glands

1991 • 50 citations

Effect of lactoferrin on the growth of a human colon adenocarcinoma cell line-comparison with transferrin

1984 • 50 citations

Breast Milk Lactoferrin Levels in Relation to Maternal Nutritional Status

1985 • 48 citations

Lactoferrin-binding proteins in Shigella flexneri

1992 • 48 citations

Lactoferrin‐mediated transfer of iron to intracellular ferritin in human monocytes

1988 • 47 citations

The leucocytes during pregnancy

1951 • 46 citations

Activation of the classical pathway of complement by binding of bovine lactoferrin to unencapsulated Streptococcus agalactiae.

1993 • 46 citations

Lactoferrin interacts with deoxyribonucleic acid: a preferential reactivity with double-stranded DNA and dissociation of DNA-anti-DNA complexes.

1982 • 46 citations

Lactoferrin and albumin in human pancreatic juice

1980 • 45 citations

Lactoferrin in human amniotic fluid

1989 • 44 citations

Stimulatory effect of human lactoferrin on DNA synthesis in BALB/c 3T3 cells.

1989 • 43 citations

Identification of a Mannoprotein Fraction from Candida albicans that Enhances Human Polymorphonuclear Leukocyte (PMNL) Functions and Stimulates Lactoferrin in PMNL Inhibition of Candidal Growth

1992 • 41 citations

PLASMA LACTOFERRIN AND NEUTROPHIL ELASTASE IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS

1990 • 41 citations

Serum and Plasma Myeloperoxidase, Elastase and Lactoferrin Content in Acute Myeloid Leukaemia

1979 • 40 citations

Vanadium transport across placenta and milk of rats to the fetus and newborn

1989 • 40 citations

Binding of lactoferrin and transferrin to the human promonocytic cell line U937. Effect on iron uptake and release.

1993 • 37 citations

Plasma Lactoferrin Measured by an Enzyme‐Linked Immunosorbent Assay (ELISA)

1983 • 35 citations

Lactoferrin binding to neutrophilic polymorphonuclear leucocytes

1983 • 35 citations

Lactoferrin-inducible monocyte cytotoxicity for K562 cells and decay of natural killer lymphocyte cytotoxicity

1991 • 34 citations

Simultaneous calcium‐dependent delivery of neutrophil lactoferrin and reactive oxygen metabolites to erythrocyte targets: Evidence supporting granule‐dependent triggering of superoxide deposition

1993 • 33 citations

High-performance liquid chromatographic separation of human apolactoferrin and monoferric and diferric lactoferrins

1992 • 33 citations

An enzyme-linked immunosorbent assay for plasma-lactoferrin. Concentrations in 362 healthy, adult blood donors

1993 • 30 citations

Serum Lactoferrin in Leukaemia and Polycythaemia vera

1972 • 27 citations

Radio-immuno assay of lactoferrin in blood plasma of breast cancer patients, lactating and normal women; prevention of false high levels caused by leakage from neutrophile leucocytes in vitro.

1971 • 27 citations

Diminished Release of Lactoferrin from Polymorphonuclear Leukocytes of Human Neonates

1987 • 26 citations

Enzyme linked immunosorbent assay for lactoferrin. Plasma and tissue measurements

1985 • 26 citations

The peroxidase activity and cellular content of granule proteins in PMN during pregnancy

1983 • 26 citations

Amino acid sequence of cysteic peptides of lactoferrin and demonstration of similarities between lactoferrin and transferrin

1974 • 25 citations

Biosynthesis and processing of lactoferrin in bone marrow cells, a comparison with processing of myeloperoxidase

1988 • 25 citations

Autoantibodies to neutrophil cytoplasmic enzymes in Felty's syndrome.

1993 • 25 citations

Regions located in both the N-lobe and C-lobe of human lactoferrin participate in the binding interaction with bacterial lactoferrin receptors

1993 • 24 citations

67Ga-transferrin and 67Ga-lactoferrin binding to tumor cells: Specific versus nonspecific glycoprotein-cell interaction

1983 • 24 citations

Inhibition of histamine release in vitro by a blocking factor from human serum: comparison with the iron binding proteins transferrin and lactoferrin

1987 • 23 citations

A non competitive enzyme immunoassay of human lactoferrin in biological fluids

1983 • 22 citations

Plasma lactoferrin levels in pregnancy and cystic fibrosis

1982 • 22 citations

A Comparative Study of Cells and Anti-microbial Proteins in Colostrum of Mothers Delivering Pre- and Full-term Babies

1991 • 22 citations

In vitro studies of lactoferrin and murine granulopoiesis

1981 • 20 citations

Lactoferrin binding to human platelets

1993 • 20 citations

Iron‐saturated lactoferrin as a comitogenic substance for neonatal rat hepatocytes in primary culture

1993 • 20 citations

Immunochemical Difference between Iron-saturated and Unsaturated Human Transferrin

1968 • 19 citations

Immuno‐electron microscopic tracing of lactoferrin, a regulator of myelopoiesis, into a subpopulation of human peripheral blood monocytes

1982 • 19 citations

Glandular secretion of lactoferrin in a patient with neutrophil lactoferrin deficiency

1989 • 19 citations

Proteins in preterm and term milk from mothers delivering appropriate or small-for-gestational age infants

1986 • 18 citations

A monoclonal antibody-based immunoassay for human lactoferrin

1985 • 17 citations

Enzyme Immunoassay of Lactoferrin in Newborn Term Infants: Reference Values and Influence of Diet

1989 • 17 citations

Immunoradiometric assay of plasma lactoferrin

1983 • 15 citations

Lactoferrin Triggers In Vitro Proliferation of T Cells of Lewis Rats Submitted to Mycobacteria‐Induced Adjuvant Arthritis

1993 • 15 citations

Lactoferrin, Anti-Lactoferrin Antibodies and Inflammatory Disease

1993 • 14 citations

Neutrophil Lactoferrin Content in Viral Infections

1988 • 14 citations

Lactoferrin interferes with uptake of iron from transferrin and asialotransferrin by the rat liver

1993 • 14 citations

Regulation of granulopoiesis: the lactoferrin controversy.

1989 • 14 citations

Serum Lactoferrin and C-Reactive Protein in Mother and Newborn After Preterm Rupture of Membranes

1986 • 13 citations

ANCA with Specificity for Lactoferrin in Systemic Lupus Erythematosus (SLE)

1993 • 13 citations

Lactoferrin, a Protein of Human Pancreatic External Secretion

1975 • 13 citations

Inhibition Effects of KRDS, a Peptide Derived from Lactotransferrin, on Platelet Function and Arterial Thrombus Formation in Dogs

1992 • 12 citations

Unsaturated Iron‐Binding Capacity of Human Milk

1982 • 11 citations

Lactoferrin in human prostate tissue

1981 • 11 citations

Elevated Serum Levels of Lactoferrin and Eosinophil Cationic Protein in Schizophrenic Patients

1982 • 11 citations

Antineutrophil Antibodies in Inlammatory Bowel Disease Recognize Different Antigens

1993 • 11 citations

Granulocyte oxygen radicals as potential suppressors of hemopoiesis: potentiating roles of lactoferrin and elastase; inhibitory role of oxygen radical scavengers.

1987 • 10 citations

Rapid radiometric assay used to assess lactoferrin in granulocytes.

1985 • 10 citations

Plasma lactoferrin reflects neutrophil activation in psoriasis

1988 • 10 citations

Ultrastructural localization of lactoferrin in the granules other than typical secondary granules of human neutrophils.

1993 • 9 citations

DISTRIBUTION OF LACTOFERRIN IN HUMAN FETAL TISSUES

1981 • 9 citations

Anti-Lactoferrin Antibodies in Patients with Rheumatoid Arthritis with Vasculitis

1993 • 8 citations

Iron Binding to Human Lactoferrin Alters Reactivity of the Protein with Plant Lectins

1993 • 8 citations

Lactoferrin Binding to Peripheral Human Leukocytes

1984 • 5 citations

[Elastase-alpha 1-proteinase inhibitor complex (E alpha 1 PI) and lactoferrin plasma concentrations in viral and bacterial infections].

1991 • 3 citations

Congenital and Acquired Lactoferrin Deficiencies in Neutrophils

1982 • 3 citations

Within-subject variation of elastase/α1-protease inhibitor complexes and lactoferrin in plasma

1993 • 2 citations

[Recent knowledge of the structure and function of lactoferrin and ferritin].

1989 • 1 citations

LACTOFERRIN IN SYNOVIAL FLUID

1977 • 1 citations

[Immunochemical comparison of lactoferrin of human milk and lactoferrin of neutrophils].

1988 • 1 citations