The Major Histocompatibility Complex: Analysis at the Protein and DNA Levels

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Evolution of Repeated DNA Sequences by Unequal Crossover

1976 • 1,208 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

Monoclonal Antibodies for Analysis of the HLA System

1979 • 745 citations

Isolation and Properties of a Low Molecular Weight β2-Globulin Occurring in Human Biological Fluids

1968 • 733 citations

Synchronised transmembrane insertion and glycosylation of a nascent membrane protein

1977 • 529 citations

Evolutionary Significance of the HL-A System

1972 • 523 citations

Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

1981 • 511 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

HLA and disease

1977 • 430 citations

The Major Histocompatibility Complex of the Mouse

1979 • 423 citations

Differential function of major histocompatibility complex antigens in T-lymphocyte activation

1976 • 419 citations

Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

1981 • 374 citations

Processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis virus G protein and the IgG heavy chain.

1978 • 362 citations

The Role of the Major Histocompatibility Complex in Immunobiology

1981 • 361 citations

A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.

1976 • 353 citations

GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKÆMOGENESIS

1964 • 350 citations

Two-gene control of the expression of a murine Ia antigen.

1978 • 328 citations

Characterization of a monoclonal anti‐β₂‐microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens

1979 • 308 citations

The organization of genetic units in chromosomes

1967 • 299 citations

Three cDNA clones encoding mouse transplantation antigens: Homology to immunoglobulin genes

1981 • 287 citations

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1979 • 283 citations

Complete amino acid sequence of β₂-microglobulin

1973 • 283 citations

Assembly and maturation of HLA-A and HLA-B antigens in vivo

1979 • 278 citations

Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and β2-microglobulin

1979 • 274 citations

The β2-microglobulin gene is on chromosome 15 and not in the HL-A region

1975 • 274 citations

Immunological dissection of human Ia molecules.

1978 • 263 citations

Highly Purified Papain-Solubilized HL-A Antigens Contain β ₂ -Microglobulin

1974 • 257 citations

THE GENETIC CONTROL OF IMMUNOGLOBULIN SYNTHESIS

1972 • 249 citations

Antigenic Properties of Experimental Leukemias. I. Serological Studies <italic>In Vitro</italic> With Spontaneous and Radiation-Induced Leuke-mias<xref ref-type="fn" rid="FN2">2</xref>

1963 • 225 citations

The Genetic Control of HLA‐A and B Antigens in Somatic Cell Hybrids: Requirement for β₂ Microglobulin

1978 • 222 citations

Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens.

1979 • 222 citations

Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitates

1979 • 217 citations

Multiple Common Properties of Human β ₂ -Microglobulin and the Common Portion Fragment Derived from HL-A Antigen Molecules

1973 • 214 citations

Structure and function of the constant regions of immunoglobulins

1976 • 206 citations

Immunological Identity of the Small Subunit of HL-A Antigens and β ₂ -Microglobulin and Its Turnover on the Cell Membrane

1974 • 205 citations

Initiation of Protein Synthesis at an Unusual Position in an Immunoglobulin Gene?

1972 • 204 citations

Glycoproteins of Blood Cells and Plasma

1972 • 199 citations

The Major Histocompatibility Complex — Genetics and Biology

1976 • 196 citations

Primary structure of a murine transplantation antigen

1981 • 194 citations

The Major Histocompatibility System in Man and Animals

1977 • 185 citations

BIOCHEMISTRY OF THE GENE PRODUCTS FROM MURINE MHC MUTANTS

1980 • 182 citations

Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies.

1979 • 173 citations

Demonstration of structural polymorphism among HLA-DR light chains by two-dimensional gel electrophoresis.

1980 • 170 citations

Carbohydrate moiety of HLA antigens. Antigenic properties and amino acid sequences around the site of glycosylation.

1977 • 169 citations

Structure of HLA antigens: amino-acid and carbohydrate compositions and NH2-terminal sequences of four antigen preparations.

1976 • 168 citations

TheTla region of the mouse: Identification of a new serologically defined locus,Qa-2

1976 • 168 citations

An approach to the mapping of antigens on the cell surface.

1968 • 167 citations

Effect of Thymine Concentration on the Replication Velocity of DNA in a Thymineless Mutant of Escherichia coli

1970 • 162 citations

A new serologically defined locus,Qa-1, in theTla-region of the mouse

1976 • 156 citations

Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.

1977 • 151 citations

Molecular similarities between the Qa-2 alloantigen and other gene products of the 17th chromosome of the mouse.

1977 • 146 citations

Molecular cloning of a human histocompatibility antigen cDNA fragment.

1980 • 145 citations

The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

1979 • 134 citations

Heavy chain of HLA-A and HLA-B antigens is conformationally labile: a possible role for beta 2-microglobulin.

1979 • 134 citations

A small polypeptide different from β2-microglobin associated with a human cell surface antigen

1979 • 131 citations

Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies

1979 • 130 citations

Detergent-solubilised H-2 alloantigen is associated with a small molecular weight polypeptide

1974 • 129 citations

Purification and structural characterisation of human HLA-linked B-cell antigens

1977 • 129 citations

Detergent-soluble HLA antigens contain a hydrophilic region at the COOH-terminus and a penultimate hydrophobic region.

1976 • 127 citations

Murine Ia and human DR antigens: homology of amino-terminal sequences.

1978 • 125 citations

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

1979 • 119 citations

Rat Thy-1 Antigens from Thymus and Brain: Their Tissue Distribution, Purification, and Chemical Composition

1977 • 116 citations

Biosynthesis and cell surface localization of nonglycosylated human histocompatibility antigens.

1981 • 113 citations

The self determinants recognized by human virus-immune T cells can be distinguished from the serologically defined HLA antigens.

1980 • 112 citations

Lymphocyte Reactivity to Serologically Undetected Components of the Major Histocompatibility Complex

1973 • 111 citations

Glycosylation of a membrane protein is restricted to the growing polypeptide chain but is not necessary for insertion as a transmembrane protein

1978 • 110 citations

Association between an HLA haplotype and low responsiveness to tetanus toxoid in man

1978 • 107 citations

Identification of the Mouse Karyotype by Quinacrine Fluorescence, and Tentative Assignment of Seven Linkage Groups

1971 • 95 citations

HLA-A, -B AND -C ANTIGENS, THEIR SEROLOGY AND CROSS-REACTION

1978 • 95 citations

Population genetics of the MLC response: typing for MLC determinants using homozygous and heterozygous reference cells.

1973 • 94 citations

Thymus-like activities of sulphur derivatives on T-cell differentiation.

1977 • 93 citations

Isolation and N-terminal amino acid sequence of membrane-bound human HLA-A and HLA-B antigens

1976 • 92 citations

Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism.

1981 • 91 citations

Sequence of the COOH-terminal hydrophilic region of histocompatibility antigens HLA-A2 and HLA-B7

1978 • 89 citations

Molecular weights of the Thy-1 glycoproteins from rat thymus and brain in the presence and absence of deoxycholate

1978 • 88 citations

Analysis of HLA-DR antigens by using monoclonal antibodies: recognition of conformational differences in biosynthetic intermediates.

1981 • 87 citations

A cycloid model for the chromosome

1967 • 84 citations

Partial Purification of Detergent-Soluble HL-A Antigen and Its Cleavage by Papain

1974 • 82 citations

Human T cell surface antigens bearing a structural relationship to HLA antigens.

1981 • 81 citations

Dissociation and exchange of the beta 2-microglobulin subunit of HLA-A and HLA-B antigens.

1979 • 81 citations

Virus-immune cytotoxic T cells recognize structural differences between serologically indistinguishable HLA-A2 molecules

1980 • 80 citations

The Major Histocompatibility Complex — Genetics and Biology

1976 • 79 citations

Structural studies of murine I-E and human DR antigens

1979 • 79 citations

Complete amino acid sequence of rabbit .beta.2-microglobulin

1979 • 78 citations

Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.

1979 • 77 citations

Immunologic properties of mouse thymus cells: Membrane antigen patterns

1973 • 76 citations

The human ‘T’ genetic region of the HLA linkage group is a polymorphism detected on lectin-activated lymphocytes

1980 • 76 citations

Structure and evolution of transplantation antigens: partial amino-acid sequences of H-2K and H-2D alloantigens.

1976 • 75 citations

cDNA clone coding for part of a mouse H-2d major histocompatibility antigen.

1981 • 75 citations

The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11).

1976 • 74 citations

Structural similarities between Thy-1 antigen from rat brain and immunoglobulin

1979 • 72 citations

Further serological analysis of the Qa antigens: Analysis of an anti-H-2.28 serum

1978 • 70 citations

Genetic polymorphism of murineβ 2-microglobulin detected biochemically

1980 • 69 citations

Associations Between Major Histocompatibility Antigens and Susceptibility to Disease

1979 • 68 citations

X-Ray Diffraction Studies of Immunoglobulins

1975 • 64 citations

Ia antigenic specificities are oligosaccharide in nature: hapten-inhibition studies.

1977 • 64 citations

Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion.

1977 • 63 citations

ISOANTIGENS OF THE H-2 AND Tla LOCI OF THE MOUSE

1968 • 62 citations

Chemical, physical-chemical, and immunological properties of papain-solubilized human transplantation antigens

1979 • 61 citations

Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.

1975 • 61 citations

Isolation and characterization of H-2 and TL alloantigens from the surface of mouse lymphocytes

1972 • 60 citations

Physical-chemical properties of β2-microglobulin

1974 • 60 citations

Enzymatic conversion of proteins to glycoproteins by lipid‐linked saccharides: A study of potential exogenous acceptor proteins

1978 • 60 citations

Split of HLA‐D into Two Regions α and β by a Recombination between HLA‐D and GLO. I. Study in a Family and Primed Lymphocyte Typing for Determinants Coded by the β Region

1980 • 60 citations

Human DR (Ia-Like) Antigens: Biological and Molecular Profile

1978 • 59 citations

The structure and function of immunoglobulin domains: studies with beta-2-microglobulin on the role of the intrachain disulfide bond.

1975 • 58 citations

Selective labelling of the hydrophobic segments of intrinsic membrane proteins with a lipophilic photogenerated carbene

1979 • 58 citations

Solubilization of Human Leucocyte Membrane Isoantigens

1968 • 57 citations

In vitro secondary mixed leukocyte reaction (MLR)

1977 • 56 citations

Reconstitution of Ir genes, Ia antigens, and mixed lymphocyte reaction determinants by gene complementation.

1981 • 54 citations

Primary structural studies of an H-2L molecule confirm that it is a unique gene product with homology to H-2K and H-2D antigens.

1980 • 54 citations

Peptide map analyses of murine Ia antigens of the I–E subregion using HPLC

1979 • 50 citations

Primary structure of murine major histocompatibility complex alloantigens: amino acid sequence of the amino-terminal one hundred and seventy-three residues of the H-2Kb glycoprotein

1980 • 49 citations

Structural studies on the murine ia alloantigens—III.

1979 • 47 citations

Isolation, characterization and amino acid sequence studies of the cyanogen bromide fragments of the H‐2 D^d glycoprotein

1980 • 46 citations

Enzymic Removal and Re-expression of a Histocompatibility Antigen, HL-A 2, at the Surface of Human Peripheral Lymphocytes

1972 • 45 citations

Induction of HLA mutations by chemical mutagens in human lymphoid cells

1977 • 44 citations

Partial N-terminal amino acid sequence of rat transplantation antigens

1978 • 44 citations

Current Trends in Histocompatibility

1981 • 42 citations

Identity of the HL-A common portion fragment and human β2-microglobulin

1973 • 42 citations

Serological and biochemical identification of hybrid Ia antigens.

1980 • 41 citations

An Evaluation of the Significance of Amino Acid Sequence Homologies in Human Histocompatibility Antigens (HLA‐A and HLA‐B) with Immunoglobulins and Other Proteins, Using Relatively Short Sequences

1980 • 41 citations

Characterization, evolution, and molecular basis of a polymorphic antigenic determinant shared by HLA-A and B products

1980 • 40 citations

Structure of the heavy chain of the H-2Kk histocompatibility antigen.

1980 • 39 citations

Molecular characterization of HLA-A, B homologues in owl monkeys and other nonhuman primates

1980 • 39 citations

Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

1977 • 39 citations

DR Typing in Australian Aborigines. An Indication for a Second Locus in the HLA—D Region Defined by Serology

1980 • 38 citations

Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 1. Isolation and amino acid composition of fragments and of tryptic and chymotryptic peptides

1979 • 37 citations

Subunit structure of thymus leukemia antigens

1975 • 36 citations

Two allelic forms of mouse beta 2-microglobulin.

1981 • 36 citations

Surface mapping of mouse thymocytes.

1979 • 36 citations

The primary structure of guinea pig β2-microglobulin

1980 • 36 citations

HLA membrane antigens: sequencing by intrinsic radioactivity.

1976 • 35 citations

Evidence against a dimeric structure for membrane-bound HLA antigens

1975 • 34 citations

Amino acid sequence of an immunoglobulin-like HLA antigen heavy chain domain.

1979 • 34 citations

Chemical characteristics of Ia antigens

1978 • 33 citations

Isolation and partial characterization of papain-solubilized murine H-2 antigens

1977 • 32 citations

Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells.

1979 • 30 citations

Cytolytic T lymphocyte precursors reactive against mutant Kb alloantigens are as frequent as those reactive against a whole foreign haplotype.

1980 • 29 citations

Thymus Cells of Radiation-Chimeras: TL Phenotype, Sensitivity to Guinea-Pig Serum, and Origin from Donor Cells

1965 • 29 citations

Human cell membrane components bound to beta2-microglobulin in T cell-type cell lines.

1978 • 29 citations

MOUSE ISOANTIGENS: SEPARATION OF SOLUBLE TL (THYMUS-LEUKEMIA) ANTIGEN FROM SOLUBLE H-2 HISTOCOMPATIBILITY ANTIGEN BY COLUMN CHROMATOGRAPHY

1967 • 28 citations

Detection of CML determinants associated with H–2 controlled Eβ and Eαchains

1981 • 28 citations

Further molecular complexities of H–2 K- and D-region antigens

1981 • 27 citations

Similarity of the Carbohydrate Structures of H-2 and Ia Glycoproteins

1977 • 26 citations

HLA and disease associations with special reference to mechanisms.

1981 • 26 citations

Papain-solubilized HL-A Antigens

1974 • 26 citations

The guinea pig I region. I. A structural and genetic analysis

1977 • 26 citations

HLA, ANKYLOSING SPONDYLITIS AND RHEUMATOID ARTHRITIS

1978 • 25 citations

A comment on the genetic data relating to expression of TL antigens.

1971 • 22 citations

Partial aminoterminal amino acid sequences of chicken major histocompatibility antigens

1978 • 22 citations

Human Cell Membrane Components Bound to β2-Microglobulin in T Cell-Type Cell Lines

1978 • 22 citations

Fragmentation of the human transplantation antigen heavy chain by limited proteolysis, acid cleavage, and cyanogen bromide treatment

1979 • 22 citations

Structural Studies of the Protein Portion of the H-2-Linked Ia Glycoprotein Antigens of the Mouse: Tryptic Peptide Comparison of Products from the I-A and I-C Subregions of B10.HTT

1978 • 21 citations

PAPAIN SOLUBILIZATION OF MOUSE H-2 ISOANTIGENS

1968 • 21 citations

Structural characterization of antigens encoded by rabbitRLA-11 histocompatibility genes

1979 • 20 citations

Crystallographic studies of bovine beta2-microglobulin.

1977 • 20 citations

The Guinea Pig MHC: Functional Significance and Structural Characterization

1977 • 17 citations

A COMMENT ON THE GENETIC DATA RELATING TO EXPRESSION OF TL ANTIGENS

1971 • 16 citations

Partial amino acid sequence of HLA-A9 antigen purified with a specific xenoantiserum.

1978 • 16 citations

The mouse-primed lymphocyte typing test. III. Dissociation of T lymphocyte-stimulating determinants and antibody-defined specificities of the I region-associated Ia antigens.

1980 • 13 citations

PARTIAL AMINO ACID SEQUENCE OF HLA-A9 ANTIGEN PURIFIED WITH A SPECIFIC XENOANTISERUM

1978 • 12 citations

Partial amino acid sequences of the heavy chains of human HLA histocompatibility antigens

1976 • 11 citations

Amino terminal sequence studies on the Ia antigens of the guinea pig

1979 • 8 citations

Chemical cross-linking of Ia alloantigen alpha and beta chains with dimethyl 3,3'-dithiobispropionimidate.

1979 • 7 citations

Chemical Cross-Linking of Ia Alloantigen α and β Chains with Dimethyl 3,3′-Dithiobispropionimidate

1979 • 6 citations

IMMUNOLOGICAL STUDIES OF HUMAN Ia-LIKE ANTIGENS11This work was supported by research grants from the U.S. Public Health Service (N.I.H. AI-10736 and AI-09576). A.F. is a fellow of the Medical Research Council, Canada. M.G.'s involvement was sponsored in part by the Dutch Organization for the Advancement of Pure Research. B.S.'s work was supported in part by the Norwegian Cancer Society

1978 • 4 citations

INABILITY TO DETECT Ia ANTIGENS IN MOUSE SERA

1978 • 3 citations