Sex Hormones and Neoplasia: Genotoxic Effects in Short Term Assays

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

1975 • 3,362 citations

Short-term tests for carcinogens and mutagens

1979 • 693 citations

Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system

1979 • 567 citations

Chromosome tests with 134 compounds on Chinese hamster cells in vitro — A screening for chemical carcinogens

1977 • 445 citations

Chemically‐induced unscheduled DNA synthesis in primary rat hepatocyte cultures: A comparison with bacterial mutagenicity using 218 compounds

1981 • 363 citations

Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential

1983 • 338 citations

Chromosome Aberrations and Sister Chromatid Exchanges in Chinese Hamster Cells Exposed to Various Chemicals 2

1977 • 330 citations

Evaluation of short-term tests for carcinogens

1986 • 280 citations

Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and noncarcinogens

1982 • 264 citations

Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells.

1978 • 245 citations

Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis.

1983 • 209 citations

Diethylstilbestrol Induces Neoplastic Transformation Without Measurable Gene Mutation at Two Loci

1981 • 185 citations

Tumour promoters induce mitotic aneuploidy in yeast

1981 • 144 citations

Appendix II. The bacterial mutation test

1978 • 136 citations

Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens.

1982 • 127 citations

Morphologic and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs.

1982 • 109 citations

Mutagenicity of methyl 2-benzimidazolecarbamate, diethylstilbestrol and estradiol: Structural chromosomal aberrations, sister-chromatid exchanges, C-mitoses, polyploidies and micronuclei

1985 • 108 citations

Metabolites of diethylstilboestrol induce sister chromatid exchange in human cultured fibroblasts

1979 • 103 citations

Non-mutagenicity of some sex hormones in the ames salmonella/microsome mutagenicity test

1979 • 101 citations

Mutagenicity assays of estrogenic hormones in mammalian cells

1981 • 91 citations

Increased induction of sister chromatid exchange by diethylstilbestrol in lymphocytes from pregnant and premenopausal women.

1982 • 85 citations

Diethylstilbestrol and 11 derivatives

1979 • 76 citations

Oxidative metabolism of diethylstilbestrol by prostaglandin synthetase.

1982 • 71 citations

Elimination of metabolic co-operation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents

1982 • 71 citations

Colchicine-like effect of diethylstilbestrol (DES) on mammalian cells in vitro

1978 • 66 citations

Chemically induced aneuploidy in mammalian cells in culture

1986 • 66 citations

Diethylstilbestrol induces metaphase arrest and inhibits microtubule assembly

1985 • 64 citations

Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell cultures.

1983 • 63 citations

Diethylstilboestrol: the binding and effects of diethylstilboestrol upon the polymerisation and depolymerisation of purified microtubule protein in vitro

1985 • 59 citations

Deceased numbers of spindle and cytoplasmic microtubules in hamster embryo cells treated with a carcinogen, diethylstilbestrol.

1986 • 57 citations

Mutagenic activity of chemicals previously tested for carcinogenicity in the National Cancer Institute bioassay program.

1980 • 53 citations

Differential staining of chromosomes and spindle and its use as an assay for determining the effect of diethylstilboestrol on cultured mammalian cells

1982 • 52 citations

Dependence on exogenous metabolic activation for induction of unscheduled DNA synthesis in Syrian hamster embryo cells by diethylstilbestrol and related compounds.

1984 • 52 citations

Appendix III. Mammalian cell transformation in vitro

1978 • 51 citations

Structural specificity of estrogens in the induction of mitotic chromatid non-disjunction in HeLa cells

1967 • 51 citations

Metabolism of stilbene estrogens and steroidal estrogens in relation to carcinogenicity

1984 • 44 citations

Aneuploidy in mouse embryos induced by diethylstilbestrol diphosphate

1974 • 43 citations

INDUCTION OF ANEUPLOIDY IN MOUSE BONE MARROW CELLS WITH DIETHYLSTILBESTROL-DIPHOSPHATE

1974 • 42 citations

Sister chromatid exchanges and cell division delays induced by diethylstilbestrol, estradiol, and estriol in human lymphocytes.

1983 • 40 citations

Diethylstilbestrol‐diphosphate induces chromosomal aberrations but not sister chromatid exchanges in murine bone marrow cells in vivo

1981 • 39 citations

Genetic activity of diethylstilbestrol in Saccharomyces cerevisiae

1982 • 35 citations

Possible role of oxygen radicals in cell transformation by diethylstilbestrol and related compounds

1986 • 34 citations

Cytogenetic effects of diethylstilbestrol-diphosphate (DES-dp) on mouse bone marrow monitored by the micronucleus test

1979 • 33 citations

Role of chemically induced mutagenic events in neoplastic transformation of Syrian hamster embryo cells.

1985 • 32 citations

Abnormal cell division in cultured human fibroblasts after exposure to diethylstilboestrol

1982 • 30 citations

Induction of sister chromatid exchange by diethylstilbestrol in metabolically competent hepatoma cell lines but not in fibroblasts.

1984 • 27 citations

Nature of the macromolecular binding of diethylstilbestrol to DNA and protein following oxidation by peroxidase/hydrogen peroxide

1985 • 26 citations

Lack of hepatogenotoxicity of oral contraceptive steroids

1982 • 26 citations

Inability of diethylstilbestrol to induce 6-thioguanine-resistant mutants and to inhibit metabolic cooperation of V79 Chinese hamster cells

1983 • 26 citations

Mutagenic activity of some clastogenic chemicals at the hypoxanthine guanine phosphoribosyl transferase locus of Chinese hamster ovary cells

1984 • 25 citations

Effect of selected estrogens and progestins on human chromosomes in vitro.

1969 • 25 citations

Effect of diethylstilbestrol on the transformable mouse embryo fibroblast C3H/10T1/2C18 cells. Tumor promotion, cell growth, DNA synthesis, and ornithine decarboxylase

1982 • 25 citations

Nuclear DNA and Histologic Studies of Genital Lesions in Diethylstilbestrol-exposed Progeny: II. Intraepithelial Glandular Abnormalities

1979 • 25 citations

Variation of superoxide dismutase levels in fetal calf serum

1983 • 23 citations

Sex Hormones and Neoplasia: Liver Tumors in Rodents

1987 • 22 citations

Induction of sister-chromatid exchanges by indirect mutagens/carcinogens in cultured rat hepatoma and esophageal tumor cells and in Chinese hamster Don cells co-cultivated with rat cells

1982 • 21 citations

Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo

1985 • 20 citations

Interaction of estrone and estradiol with DNA and protein of liver and kidney in rat and hamster in vivo and in vitro

1984 • 18 citations

Morphological transformation of Syrian hamster embryo fibroblasts by the anabolic agent trenbolone

1985 • 17 citations

Application of the Salmonella typhimurium microsome test to the study of 25 drugs belonging to 5 chemical series

1980 • 17 citations

Induction of malignant transformation by various chemicals in Balb/3T3 clone A31-1-1 cells and biological characterization of some transformants

1985 • 13 citations

Evaluation of a mutation test using S49 mouse lymphoma cells and monitoring simultaneously the induction of dexamethasone resistance, 6-thioguanine resistance and ouabain resistance

1983 • 13 citations

Induction of DNA single- and double-strand breaks by diethylstilbestrol in murine L5178Y lymphoblasts in vitro

1985 • 12 citations

Aneuploid effect of oestradiol on cultured human synovial cells.

1970 • 12 citations

Estrogen Effects on Sister Chromatid Exchanges in Mouse Uterine Cervical and Kidney Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1985 • 11 citations

Progesterone-induced alterations of oogenesis in the Chinese hamster.

1972 • 10 citations

Effect of diethylstilbestrol on the frequencies of sister chromatid exchange in vitro and in vivo.

1985 • 9 citations

Cytogenetic studies and diethyl stilboestrol

1977 • 8 citations

Increase of Sister Chromatid Exchange Formation Induced by Diethylstilbestrol

1984 • 7 citations

Mutagenicity of some contraceptive drugs in Drosophila melanogaster

1981 • 6 citations

Positive response of diethylstilbestrol in the sex-linked recessive lethal assay in Drosophila after larval feeding

1983 • 6 citations

DNA‐damaging potential of diethylstilbestrol evaluated in the germ cell unscheduled dna synthesis assay

1984 • 6 citations

DNA clastogenic activity of diethylstilbestrol

1985 • 4 citations

The induction of aneuploidy in cultured mammalian cells by diethylstilboestrol

1982 • 1 citations