Interaction of estrone and estradiol with DNA and protein of liver and kidney in rat and hamster in vivo and in vitro

Endogenous hormones as a major factor in human cancer.

1982 • 599 citations

Bioactivation as a Model for Drug Design Bioreductive Alkylation

1977 • 432 citations

In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis

1979 • 412 citations

Zum Problem der Nachweisgrenze

1965 • 295 citations

Carcinogen Testing: Current Problems and New Approaches

1981 • 252 citations

Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats.

1980 • 206 citations

Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine.

1982 • 105 citations

Formation of covalent adducts between cortisol and 16 alpha-hydroxyestrone and protein: possible role in the pathogenesis of cortisol toxicity and systemic lupus erythematosus.

1982 • 103 citations

Non-mutagenicity of some sex hormones in the ames salmonella/microsome mutagenicity test

1979 • 101 citations

Metabolism and mechanism of action of oestrogens XII. Structure and mechanism of formation of water-soluble and protein-bound metabolites of oestrone in rat-liver microsomes in vitro and in vivo

1969 • 94 citations

Mutagenicity assays of estrogenic hormones in mammalian cells

1981 • 91 citations

Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro

1973 • 79 citations

Irreversile binding of ethynyl-estradiol metabolites to protein and nucleic acids as catalyzed by rat liver microsomes and mushroom tyrosinas

1974 • 76 citations

Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity.

1978 • 54 citations

Sex hormone pharmacology

1977 • 52 citations

IARC — Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, Vol. 12: Some Carbamates, Thiocarbamates and Carbazides. 282 Seiten. International Agency for Research on Cancer, Lyon 1976. Preis: 34.— sfr; 14.—$

1977 • 51 citations

The relevance of covalent binding to mouse liver DNA to the carcinogenic action of hexachlorocyclohexane isomers

1983 • 49 citations

Chemical Nature of Reactive Intermediates as Determinant of Toxicologic Responses

1982 • 39 citations

Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo

1978 • 35 citations

Isolation and Properties of Structured Chromatin from Guerin Ascites Tumour and Rat Liver

1976 • 33 citations

Microsomal activation of estrogens and binding to nucleic acids and proteins

1977 • 31 citations

Lack of hepatogenotoxicity of oral contraceptive steroids

1982 • 26 citations

The biotransformation of 17α-ethynyl[³H]estradiol in the rat: Irreversible binding and biliary metabolites

1982 • 26 citations

Assay of some endogenous and synthetic sex steroids for tumor-initiating activity in rat liver using the Solt-Farber system

1983 • 26 citations

Irreversible protein binding of norethisterone (norethindrone) epoxide

1976 • 23 citations

Constitutive and carcinogen-derived DNA binding as a basis for the assessment of potency of chemical carcinogens.

1981 • 21 citations

Oxidative bonding of natural oestrogens to DNA by chemical and metabolic means

1977 • 20 citations

Covalent binding of diethylstilbestrol to DNA in rat and hamster liver and kidney

1982 • 18 citations

Metabolism and mechanism of action of estrogens

1967 • 14 citations

Increased DNA binding of the estrogen receptor in an estrogen-resistant mammary cancer.

1983 • 14 citations

Synthesis of 17α ‐ethynylestradiol‐6, 7‐³H and 17α‐ethynylestradiol‐6,7‐³H, 3‐cyclopentyl‐1‐¹⁴C ether

1970 • 12 citations

Lack of oestradiol-DNA binding in mouse embryo cell cultures or following rat-liver microsomal metabolism

1979 • 7 citations