Very low levels of 6-keto-prostaglandin F1 alpha in human plasma.

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica

1980 • 615 citations

Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

1977 • 412 citations

Prostacyclin is a circulating hormone

1978 • 380 citations

Generation of prostacyclin by lungs in vivo and its release into the arterial circulation

1978 • 374 citations

Clinical pharmacology of prostacyclin

1981 • 211 citations

Prostacyclin in pregnancy.

1980 • 187 citations

Regional differences in prostacyclin formation by the kidney

1978 • 142 citations

Distribution of prostaglandin biosynthetic pathways in several rat tissues. Formation of 6-ketoprostaglandin F1α

1977 • 127 citations

Metabolism of prostacyclin in rat

1978 • 111 citations

Hepatic metabolism of prostacyclin (PGI2) in the rabbit: Formation of a potent novel inhibitor of platelet aggregation

1980 • 107 citations

Metabolism of prostacyclin in blood vessels

1978 • 103 citations

A sensitive radioimmunoassay for 6-keto-prostaglandin F1α: preliminary observations on circulating concentrations

1978 • 98 citations

125I derivatives of prostaglandins

1976 • 94 citations

Is prostacyclin a physiologically important circulating anti-platelet agent?

1980 • 88 citations

Albumins stabilize prostaglandin I2

1980 • 88 citations

Synthesis and characterization of prostacyclin, 6-ketoprostaglandin F1.alpha., prostaglandin I1, and prostaglandin I3

1978 • 74 citations

Antibodies which antagonise the effects of prostacyclin

1978 • 70 citations

Measurement of 6-oxo-PGF1α in human plasma using gas chromatography-mass spectrometry

1979 • 64 citations

PRODUCTION OF 6-OXO-PGF1α BY HUMAN LUNG IN VIVO

1979 • 62 citations

Identification of the major urinary metabolites of 6-ketoprostaglandin F1α (6K-PGF1α) in the rat

1977 • 56 citations

Stability of prostaglandin I2 in human blood

1981 • 52 citations

In-vitro venous prostacyclin production, plasma 6-keto-prostaglandin F1 alpha concentrations, and diabetic retinopathy.

1981 • 52 citations

Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F1α in man

1980 • 51 citations

Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries

1980 • 47 citations

Metabolism of prostacyclin. III. Urinary metabolite profile of 6-keto PGF1α in rat

1979 • 39 citations

Determination oi 6‐keto‐prostaglandin F_lα in rabbit kidney and urine and its relation to sodium balance

1979 • 28 citations

The impermeability of the basic cell membrane to thromboxane-B2, prostacyclin and 6-keto-PGF1α

1981 • 26 citations

Combined capillary column gas chromatography—mass spectrometric method for the quantitative analysis of urinary prostaglandins

1979 • 26 citations

Prostanoid synthesis by vascular slices and cultured vascular cells of piglet aorta

1981 • 25 citations

The Effect of Clinical Prostacyclin Infusions in Advanced Arterial Disease on Platelet Function and Plasma 6‐keto PGF_1α Levels

1981 • 21 citations

Metabolism of prostacyclin in cynomolgus monkey

1981 • 21 citations

PGI2-specific antibodies administered suggest against a role for endogenous PGI2 as a circulating vasodepressor hormone in the normotensive and spontaneously hypertensive rat

1980 • 21 citations

The major product of PGG2 metabolism by aortic microsomes is 6, 15-dioxo-PGF1α

1979 • 6 citations