Estrogen cholestasis. Membranes, metabolites, or receptors?

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

1979 • 571 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver.

1984 • 393 citations

Hepatic catabolism of rat and human lipoproteins in rats treated with 17 alpha-ethinyl estradiol.

1979 • 322 citations

Uptake of bile acids by perfused rat liver

1976 • 244 citations

Prevalence of Intrahepatic Cholestasis of Pregnancy in Chile

1978 • 241 citations

Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier.

1984 • 225 citations

Estrogen Receptor in the Mammalian Liver

1976 • 213 citations

Taurocholate Transport by Rat Liver Sinusoidal Membrane Vesicles: Evidence of Sodium Cotransport

2007 • 210 citations

Alterations of hepatic Na ⁺ ,K ⁺ -ATPase and bile flow by estrogen: Effects on liver surface membrane lipid structure and function

1978 • 201 citations

Studies of Relationships among Bile Flow, Liver Plasma Membrane NaK-ATPase, and Membrane Microviscosity in the Rat

1979 • 188 citations

Physical Properties and Binding Capacity of Testosterone-Estradiol-binding Globulin in Human Plasma, Determined by Polyacrylamide Gel Electrophoresis

1971 • 173 citations

The effect of estrogen on bile formation in the rat

1969 • 167 citations

The Enigma of Intrahepatic Cholestasis of Pregnancy: Lessons from Chile

1982 • 147 citations

Recurrent jaundice of pregnancy

1959 • 145 citations

CHANGES IN SERUM BILE ACID CONCENTRATIONS DURING NORMAL PREGNANCY, IN PATIENTS WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY AND IN PREGNANT WOMEN WITH ITCHING

1981 • 143 citations

Estrogen Pharmacology. I. The Influence of Estradiol and Estriol on Hepatic Disposal of Sulfobromophthalein (BSP) in Man*

1964 • 141 citations

Reversal of Intrahepatic Cholestasis of Pregnancy in Women after High Dose S-Adenosyl-L-Methionine Administration†

1984 • 140 citations

Studies on the Mechanism of the Ethynylestradiol Impairment of Bile Flow and Bile Salt Excretion in the Rat

1971 • 133 citations

Serum bile acids in cholestasis of pregnancy

1978 • 127 citations

Modulation by S-Adenosyl-L-Methionine of Hepatic Na+, K+-ATPase, Membrane Fluidity, and Bile Flow in Rats with Ethinyl Estradiol-Induced Cholestasis

2007 • 126 citations

Taurocholate transport by rat liver canalicular membrane vesicles. Evidence for the presence of an Na+-independent transport system.

1984 • 119 citations

Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles.

1983 • 117 citations

Transport of sodium, chloride, and taurocholate by cultured rat hepatocytes

1981 • 116 citations

Identification and characterization of a bile acid receptor in isolated liver surface membranes.

1976 • 114 citations

Serum bile acid levels in pregnancy with pruritus (bii.e acids and steroids 158)

1966 • 107 citations

Characterization of cholestasis induced by estradiol-17 beta-D-glucuronide in the rat.

1980 • 104 citations

ALTERATIONS IN SULFOBROMOPHTHALEIN SODIUM-REMOVAL MECHANISMS FROM BLOOD DURING NORMAL PREGNANCY*

1963 • 102 citations

Degradation of I125-labelled serum low density lipoprotein in normal and estrogen-treated male rats

1971 • 102 citations

Biliary secretion of fluid-phase markers by the isolated perfused rat liver. Role of transcellular vesicular transport.

1985 • 101 citations

Identity of hepatic membrane transport systems for bile salts, phalloidin, and antamanide by photoaffinity labeling.

1984 • 99 citations

Hormones and the liver

1969 • 99 citations

Female Sex Steroids and Cholestasis

1987 • 97 citations

Obstetric cholestasis

1979 • 97 citations

Serum bile acid concentrations during pregnancy and their relationship to obstetric cholestasis

1986 • 96 citations

Reversal of Ethinyl Estradiol-induced Bile Secretory Failure with Triton WR-1339

1980 • 90 citations

A Study of Recurrent Jaundice in Pregnancy

1954 • 89 citations

Jaundice in pregnancy; a clinical study.

1955 • 89 citations

Characterization and quantitation of human hepatic estrogen receptor

1983 • 88 citations

Effects of Ethinyl Estradiol and Phenobarbital on Bile Acid Synthesis and Biliary Bile Acid and Cholesterol Excretion

1976 • 85 citations

Effect of ethynylestradiol on biliary excretion of bile acids, phosphatidylcolines, and cholesterol in the bile fistula rat

1977 • 85 citations

The direct radioimmunoassay of oestrogen glucuronides in human female urine

1979 • 84 citations

Idiopathic Cholestasis of Pregnancy

1967 • 84 citations

Relationship between bile flow and Na+, K+-adenosinetriphosphatase in liver plasma membranes enriched in bile canaliculi.

1977 • 79 citations

ESTROGEN PHARMACOLOGY

1966 • 78 citations

Alteration of Bile Canalicular Enzymes in Cholestasis. A POSSIBLE CAUSE OF BILE SECRETORY FAILURE

1973 • 77 citations

Reversal by Triton WR-1339 of ethynyloestradiol-induced hepatic cholesterol esterification

1978 • 67 citations

Sulfobromophthalein Clearance Tests Before and After Ethinyl Estradiol Administration, in Women and Men with Familial History of Intrahepatic Cholestasis of Pregnancy

1981 • 65 citations

Effects of Estrogen on Thyroxine-binding Globulin Metabolism in Rhesus Monkeys

1977 • 60 citations

OCCURRENCE OF HEPATIC IMPAIRMENT IN WOMEN JAUNDICED BY ORAL CONTRACEPTIVES AND IN THEIR MOTHERS AND SISTERS

1974 • 60 citations

Sodium ion‐coupled uptake of taurocholate by rat‐liver plasma membrane vesicles

1982 • 60 citations

Effect of Estradiol Benzoate on Lipid Metabolism in the Rat

1967 • 59 citations

Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity

1967 • 58 citations

Ethynylestradiol impairs bile salt uptake and Na-K pump function of rat hepatocytes

1984 • 57 citations

Steroid D-ring glucuronides: characterization of a new class of cholestatic agents in the rat.

1981 • 54 citations

The effect of oral contraceptive steroids on bile secretion and bilirubin Tm in rats

1970 • 50 citations

Prevalence of intrahepatic cholestasis of pregnancy in La Paz, Bolivia

1979 • 49 citations

OBSTETRIC CHOLESTASIS AND PRURITUS OF PREGNANCY

1967 • 48 citations

Effects of Estrogens on Renin Substrate and Uterine Weights in Rats1

1973 • 47 citations

Is normal pregnancy cholestatic?

1983 • 44 citations

Recurrent Jaundice in Pregnancy. IV. Quantitative Determination of Urinary and Biliary Estrogens, Including Studies in Pruritus Gravidarum¹

1974 • 43 citations

Effect of Pregnancy on Bile Flow and Biliary Lipids in the Hamster

1979 • 41 citations

Effects of Ethinylestradiol-Induced Cholestasis on Bile Flow and Biliary Excretion of Estradiol and Estradiol Glucuronide by the Rat

1969 • 39 citations

Effect of Phenobarbital on the Ethynyl Estradiol-Induced Cholestasis in the Rat

1973 • 38 citations

Increase in biliary permeability subsequent to intrahepatic cholestasis by estradiol valerate in rats

1987 • 37 citations

Influence of s-adenosyl-l-methionine on irreversible binding of ethynylestradiol to rat liver microsomes, and its implication in bile secretion

1979 • 36 citations

Steroid D-ring glucuronides: a new class of cholestatic agents

1985 • 32 citations

JAUNDICE IN PREGNANCY

1973 • 31 citations

Alanine uptake by liver at midpregnancy in rats

1987 • 31 citations

Hepatotoxic effects of estradiol-17 beta-D-glucuronide in the rat and monkey.

1983 • 29 citations

The effect of 17α-ethinyl-substituted steroids on adenosine triphosphatases of rat liver plasma membrane

1970 • 28 citations

HLA in Chileans with Intrahepatic Cholestasis of Pregnancy

2007 • 27 citations

Intermediary metabolism of estriol in pregnancy

1984 • 26 citations

Ethynylestradiol-17β D-ring glucuronide conjugates are potent cholestatic agents in the rat

1983 • 25 citations

Conjugation of Phenols

1982 • 25 citations

Effect of Ethynyl Estradiol on Hepatic Excretory Function of the Rat

1969 • 23 citations

Taurocholate and steroid glucuronides: mutual protection against cholestasis in the isolated perfused rat liver.

1986 • 22 citations

The effect of pregnancy on the biliary excretion of [14C]phenytoin in the rat.

1979 • 22 citations

Jaundice in pregnancy. A follow-up study of the series of women originally reported by L. Thorling. II. Present health of the women.

1974 • 19 citations

JAUNDICE IN PREGNANCY

1973 • 18 citations

The effect of pregnancy and estradiol-17 beta treatment on the biliary transport maximum of dibromosulfophthalein, and the glucuronide conjugates of 5-phenyl-5-p-hydroxyphenyl[14C]hydantoin and [14C]morphine in the isolated perfused rat liver.

1982 • 18 citations

The effect of pregnancy on the metabolism of [14C]phenytoin in the isolated perfused rat liver.

1978 • 16 citations

The effect of pregnancy and treatment with 17 beta-estradiol on the transport of organic anions into isolated rat hepatocytes.

1984 • 16 citations

Intrahepatic cholestasis of pregnancy. Clinical analysis and follow-up study of 22 cases.

1983 • 16 citations

Effects of taurocholate infusion on biliary excretion in isolated perfused rat livers. Decreased biliary excretion of dibromosulfophthalein in pregnancy.

1985 • 10 citations

The effect of estradiol-17 beta treatment on the metabolism and biliary excretion of phenytoin in the isolated perfused rat liver and in vivo.

1980 • 6 citations

The effect of diethylstilbestrol treatment on the metabolism and biliary excretion of [14C]phenytoin in the isolated perfused rat liver

1981 • 4 citations