Drug Resistance in Myeloma: Mechanisms and Approaches to Circumvention

Glutathione S-Transferases

1974 • 17,321 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Glutathione metabolism and its selective modification.

1988 • 1,975 citations

Cancer: Principles and Practice of Oncology.

1988 • 1,907 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

1982 • 704 citations

Effective Treatment of Advanced Multiple Myeloma Refractory to Alkylating Agents

1984 • 667 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis

1975 • 446 citations

Maintenance Treatment with Recombinant Interferon Alfa-2b in Patients with Multiple Myeloma Responding to Conventional Induction Chemotherapy

1990 • 389 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

Glutathione depletion and susceptibility.

1984 • 249 citations

Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer

1991 • 228 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione

1987 • 209 citations

Systemic Toxic Effects Associated With High-Dose Verapamil Infusion and Chemotherapy Administration

1991 • 185 citations

Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts.

1984 • 179 citations

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD

1989 • 162 citations

Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.

1988 • 154 citations

Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.

1990 • 148 citations

Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.

1989 • 138 citations

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

1985 • 137 citations

Development and characterization of a melphalan-resistant human multiple myeloma cell line.

1991 • 131 citations

Mechanisms of Multidrug Resistance

1995 • 120 citations

Oral melphalan kinetics

1979 • 110 citations

Transport of melphalan by sensitive and resistant L1210 cells.

1980 • 109 citations

Management of refractory myeloma: a review.

1988 • 106 citations

Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage.

1988 • 105 citations

Optimization of immunocytochemical P-glycoprotein assessment in multidrug-resistant plasma cell myeloma using three antibodies.

1990 • 90 citations

Improved survival duration with combination chemotherapy induction for multiple myeloma: a Southwest Oncology Group Study.

1986 • 88 citations

Membrane transport of antineoplastic agents

1986 • 83 citations

A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines.

1988 • 77 citations

Synergistic inhibition by verapamil and quinine of P-glycoprotein- mediated multidrug resistance in a human myeloma cell line model

1991 • 76 citations

Genetic instability in the development of drug resistance.

1985 • 70 citations

Inhibition of a Specific DNA Repair System and Nitrosourea Cytotoxicity in Resistant Human Cancer Cells

1989 • 61 citations

Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells

1989 • 41 citations

Direct relation of DNA lesions in multidrug-resistant human myeloma cells to intracellular doxorubicin concentration.

1988 • 32 citations