Potassium channel openers: effects on the vascular system

Hyperpolarizing Vasodilators Activate ATP-sensitive K ⁺ Channels in Arterial Smooth Muscle

1989 • 1,197 citations

Properties and functions of ATP-sensitive K-channels

1990 • 690 citations

Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein

1986 • 481 citations

The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on ⁸⁶Rb efflux in rat blood vessels

1986 • 264 citations

Cromakalim, nicorandil and pinacidil: Novel drugs which open potassium channels in smooth muscle

1989 • 247 citations

Structure-activity relationships of K+ channel openers

1990 • 237 citations

Potassium channel modulators: scientific applications and therapeutic promise

1990 • 212 citations

Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.

1989 • 172 citations

Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide‐sensitive channels in an insulin‐secreting cell line

1988 • 172 citations

Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans

1986 • 168 citations

Cyclic GMP as Possible Mediator of Coronary Arterial Relaxation by Nicorandil (SG-75)

1983 • 165 citations

Guanosine diphosphate activates an adenosine 5'‐triphosphate‐sensitive K+ channel in the rabbit portal vein.

1991 • 160 citations

Potassium channel openers and vascular smooth muscle relaxation

1990 • 154 citations

Role of cardiac ATP-regulated potassium channels in differential responses of endocardial and epicardial cells to ischemia.

1991 • 153 citations

Endothelium‐dependent effects of acetylcholine in rat aorta: a comparison with sodium nitroprusside and cromakalim

1988 • 138 citations

Similarities in the Mechanism of Action of Two New Vasodilator Drugs: Pinacidil and BRL 34915

1988 • 100 citations

Effect of the K+ efflux stimulating vasodilator BRL 34915 on 86Rb+ efflux and spontaneous activity in guinea-pig portal vein

1987 • 100 citations

A Ca2+-activated K+ channel from rabbit aorta: modulation by cromakalim

1989 • 92 citations

Mechanism of action and systemic and regional hemodynamics of the potassium channel activator BRL34915 and its enantiomers.

1988 • 90 citations

The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim

1990 • 87 citations

Nicorandil opens a calcium-dependent potassium channel in smooth muscle cells of the rat portal vein.

1990 • 86 citations

Pinacidil

1990 • 77 citations

Differences between the effects of cromakalim and nifedipine on agonist‐induced responses in rabbit aorta

1991 • 69 citations

The potassium channel opening action of pinacidil; studies using biochemical, ion flux and microelectrode techniques

1988 • 64 citations

Characteristics of cromakalim‐induced relaxations in the smooth muscle cells of guinea‐pig mesenteric artery and vein

1988 • 62 citations

Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil

1988 • 54 citations

Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.

1989 • 52 citations

Pinacidil opens K⁺‐selective channels causing hyperpolarization and relaxation of noradrenaline contractions in rat mesenteric resistance vessels

1988 • 49 citations

Extracellular Ca²⁺‐activated K channel in coronary artery smooth muscle cells and its role in vasodilation

1989 • 45 citations

Alterations by glyburide of effects of BRL 34915 and P 1060 on contraction, 86Rb efflux and the maxi-K+ channel in rat portal vein.

1990 • 45 citations

Possible involvement of ATP-sensitive K+ channels in the relaxant response of dog middle cerebral artery to cromakalim.

1990 • 44 citations

Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells of the guinea-pig mesenteric and portal veins.

1982 • 41 citations

ATP inhibits smooth muscle Ca ²⁺ -activated K ⁺ channels

1990 • 36 citations

Evidence that pinacidil may promote the opening of ATP‐sensitive K+ channels yet inhibit the opening of Ca²⁺‐activated K+ channels in K⁺ ‐contracted canine mesenteric artery

1990 • 36 citations

Comparison of the effects of the K⁺‐channel openers cromakalim and minoxidil sulphate on vascular smooth muscle

1991 • 35 citations

Effects of potassium channel toxins from Leiurus quinquestriatus hebraeus venom on responses to cromakalim in rabbit blood vessels

1989 • 34 citations

Mechanisms of vasodilatation induced by potassium-channel activators

1991 • 32 citations

Comparison of cromakalim-induced relaxation of potassium precontracted rabbit, cat, and rat isolated cerebral arteries

1991 • 32 citations

Actions of Nicorandil on Vascular Smooth Muscles

1987 • 31 citations

The involvement of potassium channels in the action of ciclazindol in rat portal vein

1992 • 26 citations

Comparison of effects of cromakalim and pinacidil on mechanical activity and 86Rb efflux in dog coronary arteries.

1990 • 21 citations

Pinacidil inhibits neuromuscular transmission indirectly in the guinea‐pig and rabbit mesenteric arteries

1990 • 20 citations

Effect of Pinacidil on Norepinephrine- and Potassium-Induced Contractions and Membrane Potential in Rat and Human Resistance Vessels and in Rat Aorta

1988 • 19 citations

A comparison of the actions of cromakalim and nifedipine on rabbit isolated mesenteric artery

1990 • 14 citations

Phasic contractions of canine and human coronary arteries induced by potassium channel blockers.

1986 • 13 citations

Potassium channel activators

1992 • 4 citations